About the Research
Research Theme
Development of photocatalytic radical carboxylation of inactive alkenes for the synthesis of aliphatic carboxylic acids.
Keyword
Research Outline
Since 2019, I have specialized in organic synthesis, with a particular focus on organocatalysis and diversity-oriented synthesis (DOS). My expertise includes the development and application of catalytic systems such as chiral secondary amines and cinchona-based tertiary amines (including both bifunctional and dimeric Cinchona alkaloids).
Currently, at ICReDD, my research focuses on photo-induced radical-type carboxylation using CO2. I also have a keen interest in the reactivity control of strained small molecules, such as [1.1.0]-bicyclobutanes.
To complement my synthetic background, I am actively expanding my proficiency in computational chemistry. My goal is to integrate computational tools with experimental synthesis to gain deeper insights into reaction mechanisms, ultimately fostering the development of efficient and sustainable chemical processes aligned with green chemistry principles.
Representative Research Achievements
- Switchable Synthesis of Tritylone Alcohols and 2-Benzoylbenzoate Esters from Spiroindane-1,3-Diones.
Kuan, J.-Y.; Chen, J.-H.; Han, J.-L. J. Org. Chem. 2024, 89, 12360-12369.
DOI：10.1021/acs.joc.4c01296 - Organocatalytic Vinylogous Michael Addition/Cyclization Cascade of 2-Alkylidene Indane-1,3-Diones with Enals: A Regio- and Stereocontrolled Diversity-Oriented Route to Indane-1,3-Dione Derivatives.
Kuan, J.-Y.; Chen, I.-T.; Lin, H.; Han, J.-L. Adv. Synth. Catal. 2023, 365, 3493-3504.
DOI：10.1002/adsc.202300767 - Trifluoroethanol-Mediated Decarboxylative Addition Reactions of β -Ketoacids with Diverse Electrophiles.
Guan, R.-Y.; Hsu, C.-W.; Han, J.-L. Asian J. Org. Chem. 2021, 10, 273-284.
DOI：10.1002/ajoc.202000553