About the Research
Research Theme
Development of rhodium-catalyzd synthetic methodologies
Keyword
Rhodium catalysis, Asymmetric synthesis
Research Outline
My research focuses on developing rhodium-catalyzed reactions, including asymmetric 1,2-additions of imines or iminium salts for the synthesis of chiral amines, as well as cascade reactions.
Representative Research Achievements
- Rh-Catalyzed Enantioselective Allylation of N-Tosyl- and N-Nosylaldimines: Total Synthesis of (−)-Crispine A
Chiang, P.-F.; Li, W.-S.; Jian, J.-H.; Kuo, T.-S.; Wu, P.-Y.; Wu, H.-L., Org. Lett., 2018, 20, 158–161.
DOI: 10.1021/acs.orglett.7b03523 - Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines
Li, W.-S.; Kuo, T.-S.; Hsieh, M.-C.; Tsai, M.-K.; Wu, P.-Y.; Wu, H.-L. Org. Lett., 2020, 22, 5675–5679.
DOI: 10.1021/acs.orglett.0c02069 - Enantioselective Synthesis of 1-Aryl Tetrahydroisoquinolines by the Rhodium-Catalyzed Reaction of 3,4-Dihydroisoquinolinium Tetraarylborates
Li, W.-S.; Kuo, T.-S.; Wu, P.-Y.; Chen, C.-T.; Wu, H.-L. Org. Lett., 2021, 23, 1141–1146.
DOI: 10.1021/acs.orglett.1c00198