SHIMIZU, Yohei

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SHIMIZU, Yohei
Associate Professor
Faculty of Science, Hokkaido University
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SAWAMURA, Masaya Group
Faculty Members
Postdoctoral Fellows
Research Collaborators
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    SHIMIZU, Yohei

About the Research

Research Theme

Organic Chemistry

Keyword

Chemoselective reaction, catalytic reaction
Research History

See my CV. 

Representative Research Achievements

  • Boron-Catalyzed α-Amination of Carboxylic Acids
    T. Morisawa, M. Sawamura,* Y. Shimizu*
    Org. Lett., 2019, 18, 7466–7469
    DOI: 10.1021/acs.orglett.9b02769
  • Catalytic Regio- and Enantioselective Proton Migration from Skipped Enynes to Allenes
    X.-F. Wei, T. Wakaki, T. Itoh, H.-L. Li, T. Yoshimura, A. Miyazaki, K. Oisaki, M. Hatanaka,* Y. Shimizu,* M. Kanai*
    Chem, 2019, 5, 585–599
    DOI: 10.1016/j.chempr.2018.11.022
  • Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α-C-Allyl Carboxylic Acids
    T. Fujita, T. Yamamoto, Y. Morita, H. Chen, Y. Shimizu,* M. Kanai*
    J. Am. Chem. Soc., 2018, 140, 5899-5903
    DOI: 10.1021/jacs.8b02783
  • An Expeditious Synthesis of Sialic Acid Derivatives by Copper(I)-Catalyzed Stereodivergent Propargylation of Unprotected Aldoses
    X.-F. Wei, Y. Shimizu,* M. Kanai*
    ACS Cent. Sci., 2016, 2, 21-26
    DOI: 10.1021/acscentsci.5b00360
  • Chemoselective Boron-Catalyzed Nucleophilic Activation of Carboxylic Acids for Mannich-Type Reactions
    Y. Morita, T. Yamamoto, H. Nagai, Y. Shimizu,* M. Kanai *
    J. Am. Chem. Soc., 2015, 137, 7075-7078
    DOI:10.1021/jacs.5b04175

Related Research

Publications

2025

  • Silver-Catalyzed Asymmetric Aldol Reaction of Nonactivated Ketones with α-Isocyanocarboxylic Acid Derivatives Enabled by Prolinol-phosphine-sec-amine Chiral Ligand
    S. Sakai, K. Uchiyama, K. Imai, K. Yato, M. Onizawa, K. Higashida, H. Sato, Y. Aoyama, Y. Shimizu, M. Sawamura, Acs Catalysis, 2025, ,
    DOI: 10.1021/acscatal.5c04986
  • Phosphorus Catalysis Enabling α-Sp3-C-H Amination of 2-Alkylpyridines
    Y. Heike, A. Tagata, A. Yada, K. Nozawa-Kumada, M. Sawamura, Y. Shimizu, Organic Chemistry Frontiers, 2025, ,
    DOI: 10.1039/d5qo00960j
  • Photoinduced Direct β-Allylation of Carboxylic Acids Enabled by Boron Catalysis with a Mixed Two-Ligand System
    K. Sun, Y. Heike, Y. Yoshida, M. Sawamura, D. Huang, Y. Shimizu, Chemcatchem, 2025, ,
    DOI: 10.1002/cctc.202500091

2024

  • Oxyamination of Alkenes Enabled by Direct Photoexcitation of Fluorenone Oxime Derivatives
    A. Tagata, M. Sawamura, Y. Shimizu, Chem. Lett., 2024, 53 (12),
    DOI: 10.1093/chemle/upae216
  • Boron-Catalyzed Michael Reaction of Donor-Acceptor Carboxylic Acid Pairs Enabling Direct Synthesis of 1,5-Dicarboxylic Acids
    Y. Yoshida, M. Sawamura, Y. Shimizu, Org. Lett., 2024, 26 (26), 5425-5429
    DOI: 10.1021/acs.orglett.4c01542

2023

  • Direct a-Trifluoromethylthiolation of Carboxylic Acids Enabled by Boron Catalysis
    K. Sun, C. Y. D. Huang, M. Sawamura, Y. Shimizu, Synlett, 2023, ,
    DOI: 10.1055/a-2071-4465
  • Boron-Catalyzed Alpha-Functionalizations of Carboxylic Acids
    Y. Shimizu, M. Kanai, Chemical Record, 2023, ,
    DOI: 10.1002/tcr.202200273

2022

  • Boron Catalysis in the Transformation of Carboxylic Acids and Carboxylic Acid Derivatives
    M. Sawamura, Y. Shimizu, European Journal of Organic Chemistry, 2022, ,
    DOI: 10.1002/ejoc.202201249
  • Silver-Catalyzed Asymmetric Aldol Reaction of Isocyanoacetic Acid Derivatives Enabled by Cooperative Participation of Classical and Nonclassical Hydrogen Bonds
    S. Sakai, A. Fujioka, K. Imai, K. Uchiyama, Y. Shimizu, K. Higashida, M. Sawamura, Adv. Synth. Catal., 2022, 364, 2333-2339
    DOI: 10.1002/adsc.202200327
  • Insights into the Mechanism of Enantioselective Copper-Catalyzed Ring-Opening Allylic Alkylation of Cyclopropanols
    A. Kitabayashi, S. Mizushima, K. Higashida, Y. Yasuda, Y. Shimizu, M. Sawamura, Adv. Synth. Catal., 2022, 364, 1855-1862
    DOI: 10.1002/adsc.202200157

2021

  • Visible Light-Induced Reductive Alkynylation of Aldehydes by Umpolung Approach
    I. Tanaka, M. Sawamura, Y. Shimizu, Org. Lett., 2021, 24, 520-524
    DOI: 10.1021/acs.orglett.1c03927
  • Synthesis of C,N,N-Cyclometalated Gold(III) Complexes with Anionic Amide Ligands
    R. Niizeki, K. Higashida, E. Mejri, M. Sawamura, Y. Shimizu, Synlett, 2021, 33, 288-292
    DOI: 10.1055/a-1673-9236
  • Visible-Light-Driven Alpha-Allylation of Carboxylic Acids
    K. Sun, M. Ueno, K. Imaeda, K. Ueno, M. Sawamura, Y. Shimizu, Acs Catalysis, 2021, 11, 9722-9728
    DOI: 10.1021/acscatal.1c02558

2020

  • Iridium-Catalyzed Enantioselective Transfer Hydrogenation of Ketones Controlled by Alcohol Hydrogen-Bonding and Sp(3)-C-H Noncovalent Interactions
    H. Murayama, Y. Heike, K. Higashida, Y. Shimizu, N. Yodsin, Y. Wongnongwa, S. Jungsuttiwong, S. Mori, M. Sawamura, Adv. Synth. Catal., 2020, 362, 4655-4661
    DOI: 10.1002/adsc.202000615
  • Development of Copper-Catalyzed Chemoselective Reactions
    Y. Shimizu, Chemical & Pharmaceutical Bulletin, 2020, 68, 405-420
    DOI: 10.1248/cpb.c19-00739
  • Copper-Catalyzed Enantioselective Conjugate Reduction of Alpha,beta-Unsaturated Esters with Chiral Phenol-Carbene Ligands
    S. Mimura, S. Mizushima, Y. Shimizu, M. Sawamura, Beilstein Journal of Organic Chemistry, 2020, 16, 537-543
    DOI: 10.3762/bjoc.16.50

2019

  • Asymmetric Synthesis of α-Alkylidene-β-Lactams Through Copper Catalysis with a Prolinol-Phosphine Chiral Ligand
    K. Imai, Y. Takayama, H. Murayama, H. Ohmiya, Y. Shimizu, M. Sawamura, Org. Lett., 2019, 21, 1717-1721
    DOI: 10.1021/acs.orglett.9b00276
  • Boron-Catalyzed Alpha-Amination of Carboxylic Acids
    T. Morisawa, M. Sawamura, Y. Shimizu, Org. Lett., 2019, 21, 7466-7469
    DOI: 10.1021/acs.orglett.9b02769