About the Research
Research Theme
Organic Chemistry
Keyword
Chemoselective reaction, catalytic reaction
Research History
See my CV.
Representative Research Achievements
- Boron-Catalyzed α-Amination of Carboxylic Acids
T. Morisawa, M. Sawamura,* Y. Shimizu*
Org. Lett., 2019, 18, 7466–7469
DOI: 10.1021/acs.orglett.9b02769 - Catalytic Regio- and Enantioselective Proton Migration from Skipped Enynes to Allenes
X.-F. Wei, T. Wakaki, T. Itoh, H.-L. Li, T. Yoshimura, A. Miyazaki, K. Oisaki, M. Hatanaka,* Y. Shimizu,* M. Kanai*
Chem, 2019, 5, 585–599
DOI: 10.1016/j.chempr.2018.11.022 - Chemo- and Enantioselective Pd/B Hybrid Catalysis for the Construction of Acyclic Quaternary Carbons: Migratory Allylation of O-Allyl Esters to α-C-Allyl Carboxylic Acids
T. Fujita, T. Yamamoto, Y. Morita, H. Chen, Y. Shimizu,* M. Kanai*
J. Am. Chem. Soc., 2018, 140, 5899-5903
DOI: 10.1021/jacs.8b02783 - An Expeditious Synthesis of Sialic Acid Derivatives by Copper(I)-Catalyzed Stereodivergent Propargylation of Unprotected Aldoses
X.-F. Wei, Y. Shimizu,* M. Kanai*
ACS Cent. Sci., 2016, 2, 21-26
DOI: 10.1021/acscentsci.5b00360 - Chemoselective Boron-Catalyzed Nucleophilic Activation of Carboxylic Acids for Mannich-Type Reactions
Y. Morita, T. Yamamoto, H. Nagai, Y. Shimizu,* M. Kanai *
J. Am. Chem. Soc., 2015, 137, 7075-7078
DOI:10.1021/jacs.5b04175
Publications
2023
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Direct a-Trifluoromethylthiolation of Carboxylic Acids Enabled by Boron Catalysis
, C. Y. D. Huang, M. Sawamura, Y. Shimizu, Synlett, 2023, ,
DOI: 10.1055/a-2071-4465
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Boron-Catalyzed Alpha-Functionalizations of Carboxylic Acids
, M. Kanai, Chemical Record, 2023, ,
DOI: 10.1002/tcr.202200273
2022
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Boron Catalysis in the Transformation of Carboxylic Acids and Carboxylic Acid Derivatives
, Y. Shimizu, European Journal of Organic Chemistry, 2022, ,
DOI: 10.1002/ejoc.202201249
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Silver-Catalyzed Asymmetric Aldol Reaction of Isocyanoacetic Acid Derivatives Enabled by Cooperative Participation of Classical and Nonclassical Hydrogen Bonds
, A. Fujioka, K. Imai, K. Uchiyama, Y. Shimizu, K. Higashida, M. Sawamura, Adv. Synth. Catal., 2022, 364, 2333-2339
DOI: 10.1002/adsc.202200327
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Insights into the Mechanism of Enantioselective Copper-Catalyzed Ring-Opening Allylic Alkylation of Cyclopropanols
, S. Mizushima, K. Higashida, Y. Yasuda, Y. Shimizu, M. Sawamura, Adv. Synth. Catal., 2022, 364, 1855-1862
DOI: 10.1002/adsc.202200157
2021
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Visible Light-Induced Reductive Alkynylation of Aldehydes by Umpolung Approach
, M. Sawamura, Y. Shimizu, Org. Lett., 2021, 24, 520-524
DOI: 10.1021/acs.orglett.1c03927
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Synthesis of C,N,N-Cyclometalated Gold(III) Complexes with Anionic Amide Ligands
, K. Higashida, E. Mejri, M. Sawamura, Y. Shimizu, Synlett, 2021, 33, 288-292
DOI: 10.1055/a-1673-9236
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Visible-Light-Driven Alpha-Allylation of Carboxylic Acids
, M. Ueno, K. Imaeda, K. Ueno, M. Sawamura, Y. Shimizu, Acs Catalysis, 2021, 11, 9722-9728
DOI: 10.1021/acscatal.1c02558
2020
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Iridium-Catalyzed Enantioselective Transfer Hydrogenation of Ketones Controlled by Alcohol Hydrogen-Bonding and Sp(3)-C-H Noncovalent Interactions
, Y. Heike, K. Higashida, Y. Shimizu, N. Yodsin, Y. Wongnongwa, S. Jungsuttiwong, S. Mori, M. Sawamura, Adv. Synth. Catal., 2020, 362, 4655-4661
DOI: 10.1002/adsc.202000615
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Development of Copper-Catalyzed Chemoselective Reactions
, Chemical & Pharmaceutical Bulletin, 2020, 68, 405-420
DOI: 10.1248/cpb.c19-00739
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Copper-Catalyzed Enantioselective Conjugate Reduction of Alpha,beta-Unsaturated Esters with Chiral Phenol-Carbene Ligands
, S. Mizushima, Y. Shimizu, M. Sawamura, Beilstein Journal of Organic Chemistry, 2020, 16, 537-543
DOI: 10.3762/bjoc.16.50
2019
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Asymmetric Synthesis of α-Alkylidene-β-Lactams Through Copper Catalysis with a Prolinol-Phosphine Chiral Ligand
, Y. Takayama, H. Murayama, H. Ohmiya, Y. Shimizu, M. Sawamura, Org. Lett., 2019, 21, 1717-1721
DOI: 10.1021/acs.orglett.9b00276
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Boron-Catalyzed Alpha-Amination of Carboxylic Acids
, M. Sawamura, Y. Shimizu, Org. Lett., 2019, 21, 7466-7469
DOI: 10.1021/acs.orglett.9b02769