Hokkaido University Institute for Chemical Reaction Design and Discovery

Research Outline

We are challenging the control of active species (anions, radicals, and cations) involved in chemical reactions by creating novel molecules and eliciting the catalytic power inherent in the structure. In addition, we aim to create new chemical reactions through the experimental and theoretical understanding the behavior of molecules.

Representative Research Achievements

• Urea as a Redox-active Directing Group under Asymmetric Photocatalysis of Iridium-Chiral Borate Ion Pairs
  D. Uraguchi, Y. Kimura, F. Ueoka, T. Ooi. J. Am. Chem. Soc., 2020, 142, 19462-19467.
  DOI: 10.1021/jacs.0c09468
• A Structurally Robust Chiral Borate Ion: Molecular Design, Synthesis, and Asymmetric Catalysis
  D. Uraguchi, F. Ueoka, N. Tanaka, T. Kizu, W. Takahashi, T. Ooi. Angew. Chem. Int. Ed., 2020, 59, 11456-11461.
  DOI: 10.1002/anie.202001637
• Unveiling Latent Photoreactivity of Imines
  D. Uraguchi, Y. Tsuchiya, T. Ohtani, T. Enomoto, S. Masaoka, D. Yokogawa, T. Ooi. Angew. Chem. Int. Ed., 2020, 59, 3665-3670.
  DOI: 10.1002/anie.201913555
• Catalyst-Directed Guidance of Sulfur-Substituted Enediolates to Stereoselective Carbon-Carbon Bond Formation with Aldehydes
  D. Uraguchi, K. Yamada, M. Sato, T. Ooi. J. Am. Chem. Soc., 2018, 140, 5110-5117.
  DOI: 10.1021/jacs.7b12949
• Molecular Design, Synthesis, and Asymmetric Catalysis of a Hexacoordinated Chiral Phosphate Ion
  D. Uraguchi, H. Sasaki, Y. Kimura, T. Ito, T. Ooi. J. Am. Chem. Soc., 2018, 140, 2765-2768.
  DOI: 10.1021/jacs.7b13433