About the Research
Research Theme
Development of new reactions, constructing new and interesting organic compounds
Keyword
Synthetic chemistry, asymmetric catalysis, new methodology
Research Outline
I was focusing on the asymmetric synthesis of new chiral compounds, and discovery of new reactions by designing substrates in the past few years, especially on the field of decarboxylative transformations of cyclic carbonates and carbamates. Now, I concentrate my attention on the design and discovery of new reaction based on the computational chemistry.
Representative Research Achievements
- Electrochemical Dearomative Dicarboxylation of Heterocycles with Highly Negative Reduction Potentials
Y. You, W. Kanna, H. Takano, H. Hayashi, S. Maeda, T. Mita, J. Am. Chem. Soc., 2022, 144, 3685-3695
DOI: 10.1021/jacs.1c13032 - Recent Advances in the Catalytic Umpolung Carboxylation of Allylic Alcohol Derivatives with Carbon Dioxide
Y. You, T. Mita, Asian J. Org. Chem., 2022, 11, e202200082
DOI: 10.1002/ajoc.202200082 - Radical Difunctionalization of Gaseous Ethylene Guided by Quantum Chemical Calculations: Selective Incorporation of Two Molecules of Ethylene
H. Takano, Y. You, H. Hayashi, Y. Harabuchi, S. Maeda, T. Mita, ACS Omega, 2021, 6, 33846-33854
DOI: 10.1021/acsomega.1c05102 - Copper-Catalyzed Decarboxylative [3 + 2] Annulation of Ethynylethylene Carbonates with Azlactones: Access to γ-Butyrolactones Bearing Two Vicinal Quaternary Carbon Centers
W.-Y. Lu, Y. Wang, Y. You, Z.-H. Wang, J.-Q. Zhao, M.-Q. Zhou, W.-C. Yuan, J. Org. Chem., 2021, 86, 1779-1788
DOI: 10.1021/acs.joc.0c02621 - Catalytic asymmetric [4+2] cycloaddition of 1-((2-aryl)vinyl)naphthalen-2-ols with in situ generated ortho-quinone methides for the synthesis of polysubstituted chromanes
Y. You, T.-T. Li, S.-P. Yuan, K.-X. Xie, Z.-H. Wang, J.-Q. Zhao, M.-Q. Zhou, W.-C. Yuan, Chem. Commun., 2020, 56, 439-442
DOI: 10.1039/c9cc08316b - Enantioselective synthesis of isoquinoline-1,3(2H,4H)-dione derivatives via a chiral phosphoric acid catalyzed aza-Friedel–Crafts reaction
Y. You, W.-Y. Lu, K.-X. Xie, J.-Q. Zhao, Z.-H. Wang, W.-C. Yuan, Chem. Commun., 2019, 55, 8478-8481
DOI: 10.1039/c9cc04057a - Organocatalytic Asymmetric [3 + 2] Cycloaddition of N‑2,2,2-Trifluoroethylisatin Ketimines with β‑Trifluoromethyl Electron-Deficient Alkenes: Access to Vicinally Bis(trifluoromethyl)-Substituted 3,2′-Pyrrolidinyl Spirooxindoles
Y. You, W.-Y. Lu, Z.-H. Wang, Y.-Z. Chen, X.-Y. Xu, X.-M. Zhang, W.-C. Yuan, Org. Lett., 2018, 20, 4453−4457
DOI: 10.1021/acs.orglett.8b01730