Hokkaido University

Institute for Chemical Reaction Design and Discovery

研究概要

私たちの研究室では、放射線や光のエネルギーを利用し生体内の分子を見る研究や生体内の分子を操る研究を行います。電磁波の特徴を利用する物理学的視点、それを化合物開発へ応用する化学的視点、ヒト生体へ応用する生物学的・臨床的視点を持って取り組みます。
ICReDDでは計算化学者、情報科学者と共同し、電磁波で機能する新しい化合物の創成を行います。

代表的な研究成果

• Axial-ligand-cleavable silicon phthalocyanines triggered by near-infrared light toward design of photosensitizers for photoimmunotherapy. Takakura H, Matsuhiro S, Kobayashi M., Goto Y., Harada M., Taketsugu T., Ogawa M.  Journal of Photochemistry and Photobiology A: Chemistry. 2022, 426(1):113749. DOI:10.1016/j.jphotochem.2021.113749
• Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation. Takakura H., Matsuhiro S., Inanami O., Kobayashi M., Saita K., Yamashita M., Nakajima K., Suzuki M., Miyamoto N., Taketsugu T., Ogawa M. Org. Biomol. Chem. 2022, 20(36):7270-7.
  DOI: 10.1039/d2ob00957a
• EPR Characterisation of Phthalocyanine Radical Anions in Near-Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700. Inanami O., Hiraoka W., Goto Y., Takakura H., Ogawa M. Chem. Photo. Chem. 2021, 6(1):e202100172.
  DOI: 10.1002/cptc.202100277
• Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation. Kobayashi M., Harada M., Takakura H., Ando K., Goto Y., Tsuneda T., Ogawa M., Taketsugu T.  Chempluschem. 2020, 85(9):1959-63.
  DOI: 10.1002/cplu.202000338
• Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Mitsunaga M., Ogawa M., Kosaka N., Rosenblum L.T., Choyke P.L., Kobayashi H.  Nat Med. 2011, 17(12):1685-91.
  DOI: 10.1038/nm.2554