Hokkaido University Institute for Chemical Reaction Design and Discovery

Research Outline

In our laboratory, we will conduct research that utilizes the energy of radiation and light to visualize and manipulate molecules in humans. We work from the physics perspective of utilizing electromagnetic waves, the chemistry perspective of applying them to compound development, and the biology and clinical perspective of applying them to the human organism.
We will collaborate with ICReDD members to create new compounds that function with electromagnetic waves.

Representative Research Achievements

• Axial-ligand-cleavable silicon phthalocyanines triggered by near-infrared light toward design of photosensitizers for photoimmunotherapy. Takakura H, Matsuhiro S, Kobayashi M., Goto Y., Harada M., Taketsugu T., Ogawa M.  Journal of Photochemistry and Photobiology A: Chemistry. 2022, 426(1):113749. DOI:10.1016/j.jphotochem.2021.113749
• Ligand release from silicon phthalocyanine dyes triggered by X-ray irradiation. Takakura H., Matsuhiro S., Inanami O., Kobayashi M., Saita K., Yamashita M., Nakajima K., Suzuki M., Miyamoto N., Taketsugu T., Ogawa M. Org. Biomol. Chem. 2022, 20(36):7270-7.
  DOI: 10.1039/d2ob00957a
• EPR Characterisation of Phthalocyanine Radical Anions in Near-Infrared Photocleavage of the Hydrophilic Axial Ligand of a Photoimmunotherapeutic Reagent, IR700. Inanami O., Hiraoka W., Goto Y., Takakura H., Ogawa M. Chem. Photo. Chem. 2021, 6(1):e202100172.
  DOI: 10.1002/cptc.202100277
• Theoretical and Experimental Studies on the Near-Infrared Photoreaction Mechanism of a Silicon Phthalocyanine Photoimmunotherapy Dye: Photoinduced Hydrolysis by Radical Anion Generation. Kobayashi M., Harada M., Takakura H., Ando K., Goto Y., Tsuneda T., Ogawa M., Taketsugu T.  Chempluschem. 2020, 85(9):1959-63.
  DOI: 10.1002/cplu.202000338
• Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Mitsunaga M., Ogawa M., Kosaka N., Rosenblum L.T., Choyke P.L., Kobayashi H.  Nat Med. 2011, 17(12):1685-91.
  DOI: 10.1038/nm.2554