About the Research
Research Theme
Development of photoacoustic imaging agents based on cyanine dyes
Keyword
Activatable probes, cancer, cyanine dyes, photoacoustic imaging, pH
Research Outline
My research has focused on the development of photoacoustic imaging agents for cancer imaging using cyanine dyes. In one of my research projects, I developed amine-substituted pH-responsive dyes for high contrast cancer detection. This involved the synthesis of cyanine dyes, measurement of their absorption and photoacoustic spectra, and cancer imaging using the dyes with cancer-specific antibodies. Currently, I am trying to identify key properties for highly efficient PA dyes by integrating experimental results with theoretical insights.
Representative Research Achievements
- Piperazine based pH-responsive cyanine dyes for cancer cell photoacoustic imaging
K. Tsuchiya, H. Takakura, K. Nakajima, N. Ieda, T. Kaneko, T. Hirasawa, M. Kobayashi, Y. Yamaoka, M. Ishihara, T. Taketsugu, M. Ogawa. J. Photochem. Photobiol. A, 2024, 453, 115634.
DOI: 10.1016/j.jphotochem.2024.115634