About the Research
Research Theme
Development of light-responsive biofunctional molecules
Keyword
Chemical biology, Photochemistry
Research Outline
We develop functional molecules triggered by light in specific biological environments. Furthermore, we also aim to develop novel therapeutic agents by observing and controlling the activity and behavior of biofunctional molecules in vivo.
Representative Research Achievements
- Asymmetric bismuth-rhodamines as an activatable fluorogenic photosensitizer
A. Mukaimine, T. Hirayama, H. Nagasawa. Org. Biomol. Chem., 2021, 19, 3611–3619.
DOI: 10.1039/D0OB02456B - Bismuth-rhodamine: a new red light-excitable photosensitizer
T. Hirayama, A. Mukaimine, K. Nishigaki, H. Tsuboi, S. Hirosawa, K. Okuda, M. Ebihara, H. Nagasawa. Dalton Trans., 2017, 46, 15991–15995.
DOI: 10.1039/C7DT03194G
Publications
2026
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Targeted Photo-Induced Elimination of Tumor-Associated Macrophages Suppresses Cancer Progression in a Murine Model
, T. Uchiyama, K. Funayama, Y. Goto, A. Mukaimine, N. Ieda, M. Ogawa, Cancer Sci., 2026, ,
DOI: 10.1111/cas.70489
2025
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Effect of Hydroxy Groups on X-Ray-Induced Reactions of Azo Benzene Derivatives
, N. Ieda, H. Takakura, K. Nakajima, A. Mukaimine, M. Harada, K. Hashimoto, O. Inanami, M. Ogawa, Org. Biomol. Chem., 2025, 23, 3595-3600
DOI: 10.1039/d5ob00003c