Hokkaido University

Institute for Chemical Reaction Design and Discovery

2025

• Enumeration Approach to Atom-to-Atom Mapping Accelerated by Ising Computing
  M. Ali, Y. Mizuno, S. Akiyama, Y. Nagata, T. Komatsuzaki, J. Chem. Inf. Model., 2025, ,
  DOI: 10.1021/acs.jcim.4c01871
  
• Helicene-Fluorescein Hybrids: A Reversible Base-Triggered (Chir)optical Switch with Sign Inversion of Circularly Polarized Luminescence
  S. Miwa, D. Mizutani, K. Kawano, K. Matsuzaki, Y. Nagata, K. Tsubaki, K. Takasu, H. Takikawa, Chem. Eur. J., 2025, , e202500335
  DOI: 10.1002/chem.202500335
  

2024

• Diastereoselective Polypseudorotaxane Formation with Planar Chiral Pillar[5]arenes via Co-Crystallization Processes
  K. Yasuzawa, K. Wada, S. Fa, Y. Nagata, K. Kato, S. Ohtani, M. Mizuno, T. Ogoshi, Angew. Chem., Int. Ed., 2024, ,
  DOI: 10.1002/anie.202420115
  
• A Framework for Reviewing the Results of Automated Conversion of Structured Organic Synthesis Procedures from the Literature
  K. Machi, S. Akiyama, Y. Nagata, M. Yoshioka, Digital Discovery, 2024, ,
  DOI: 10.1039/d4dd00335g
  
• Dynamics of Side Chains in Poly(quinoxaline-2,3-Diyl)s Studied via Quasielastic Neutron Scattering
  R. Inoue, Y. Nagata, T. Tominaga, S. Sato, Y. Kawakita, T. Yamawaki, K. Morishima, M. Suginome, M. Sugiyama, J. Chem. Phys., 2024, 161, 054905
  DOI: 10.1063/5.0215603
  
• Modular, Scalable Total Synthesis of Neopetromin
  H. Ogawa, Y. Nagata, H. Nakamura, CHINESE JOURNAL OF CHEMISTRY, 2024, 42, 23, 3023-3028
  DOI: 10.1002/cjoc.202400637
  
• Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage
  J. Zhang, L. Yu, H. Ogawa, Y. Nagata, H. Nakamura, Angew. Chem., Int. Ed., 2024, 63, 42, e202409987
  DOI: 10.1002/anie.202409987
  
• Tetraborylation of p-Benzynes Generated by the Masamune-Bergman Cyclization through Reaction Design Based on the Reaction Path Network
  S. Nakatsuka, S. Akiyama, Y. Harabuchi, S. Maeda, Y. Nagata, Jacs Au, 2024, 4, 2578-2584
  DOI: 10.1021/jacsau.4c00302
  
• Carbonyl Mediated Fluorescence in Aceno[n]helicenones and Fluoreno[n]helicenes
  M. Sámal, L. Sturm, M. Banasiewicz, I. Deperasinska, B. Kozankiewicz, O. Morawski, Y. Nagata, P. Dechambenoit, H. Bock, A. Rossel, M. Budesínsky, A. Boudier, A. Jancarík, Chem. Sci., 2024, 15, 9842-9850
  DOI: 10.1039/d4sc00892h
  
• Self-Inclusion Complexation of Electron-Accepting Guest into Electron-Donating Cyclic Host by Photoexcitation
  K. Wada, Y. Nagata, L. X. Cui, T. Ono, S. Akine, S. Ohtani, K. Kato, S. Fa, T. Ogoshi, Angew. Chem., Int. Ed., 2024, ,
  DOI: 10.1002/anie.202404409
  
• Atroposelective Total Synthesis of Cihunamide B
  L. H. Yu, Y. Nagata, H. Nakamura, J. Am. Chem. Soc., 2024, 146, 4, 2549-2555
  DOI: 10.1021/jacs.3c11016
  

2023

• OSPAR: A Corpus for Extraction of Organic Synthesis Procedures with Argument Roles
  K. Machi, S. Akiyama, Y. Nagata, M. Yoshioka, J. Chem. Inf. Model., 2023, 63, 21, 6619-6628
  DOI: 10.1021/acs.jcim.3c01449
  
• Microfluidic Platform Using Focused Ultrasound Passing through Hydrophobic Meshes with Jump Availability
  Y. Koroyasu, T. V. Nguyen, S. Sasaguri, A. Marzo, I. Ezcurdia, Y. Nagata, T. Yamamoto, N. Nomura, T. Hoshi, Y. Ochiai, T. Fushimi, Pnas Nexus, 2023, 2, 7, pgad207
  DOI: 10.1093/pnasnexus/pgad207
  
• Synthesis and Chiroptical Properties of Binaphthyl-Hinged [5]Helicenes
  M. Hasegawa, Y. Nojima, Y. Nagata, K. Usui, K. I. Sugiura, Y. Mazaki, European Journal of Organic Chemistry, 2023, ,
  DOI: 10.1002/ejoc.202300656
  
• Diastereoselective Rotaxane Synthesis with Pillar 5 Arenes via Co-Crystallization and Solid-State Mechanochemical Processes
  K. Wada, K. Yasuzawa, S. X. Fa, Y. Nagata, K. Kato, S. Ohtani, T. Ogoshi, J. Am. Chem. Soc., 2023, 145, 28, 15324–15330
  DOI: 10.1021/jacs.3c02919
  
• Synthesis of Cationic Azatriphenylene Derivatives by Electrochemical Intramolecular Pyridination and Characterization of Their Optoelectronic Properties
  Y. Ohno, S. Ando, D. Furusho, R. Hifumi, Y. Nagata, I. Tomita, S. Inagi, Org. Lett., 2023, ,
  DOI: 10.1021/acs.orglett.3c01341
  
• Amino-Ene Click Reaction of Electron-Deficient Pi-Conjugated Molecules with Negative Activation Enthalpies
  H. Sanematsu, Y. Nagata, M. Takeuchi, A. Takai, Chem. Eur. J., 2023, ,
  DOI: 10.1002/chem.202301019
  
• Adaptive Planar Chirality of Pillar[5]arenes Invertible by n-Alkane Lengths
  K. Adachi, S. Fa, K. Wada, K. Kato, S. Ohtani, Y. Nagata, S. Akine, T. Ogoshi, J. Am. Chem. Soc., 2023, 145, 8114-8121
  DOI: 10.1021/jacs.3c01019
  
• Highly Chemoselective Ligands for Suzuki-Miyaura Cross-Coupling Reaction Based on Virtual Ligand-Assisted Screening
  W. Matsuoka, Y. Harabuchi, Y. Nagata, S. Maeda, Org. Biomol. Chem., 2023, 21, 3132-3142
  DOI: 10.1039/d3ob00398a
  
• Aggregation-Induced Circularly Polarized Phosphorescence of Pt(ii) Complexes with an Axially Chiral BINOL Ligand
  D. Tauchi, T. Koida, Y. Nojima, M. Hasegawa, Y. Mazaki, A. Inagaki, K. I. Sugiura, Y. Nagaya, K. Tsubaki, T. Shiga, Y. Nagata, H. Nishikawa, Chem. Commun., 2023, 27,
  DOI: 10.1039/d2cc06198h
  
• Predicting Highly Enantioselective Catalysts Using Tunable Fragment Descriptors
  N. Tsuji, P. Sidorov, C. D. Zhu, Y. Nagata, T. Gimadiev, A. Varnek, B. List, Angew. Chem., Int. Ed., 2023, e202218659,
  DOI: 10.1002/anie.202218659
  
• TEtraQuinolines: A Missing Link in the Family of Porphyrinoid Macrocycles
  W. Xu, Y. Nagata, N. Kumagai, J. Am. Chem. Soc., 2023, 145, 4, 2609–2618
  DOI: 10.1021/jacs.2c12582
  

2022

• Discrete Chiral Organic Nanotubes by Stacking Pillar 5 Arenes Using Covalent Linkages
  T. H. Shi, S. Fa, Y. Nagata, K. Wada, S. Ohtani, K. Kato, T. Ogoshi, Cell Reports Physical Science, 2022, 3,
  DOI: 10.1016/j.xcrp.2022.101173
  
• A Twisted Chiral Cavitand with 5-Fold Symmetry and Its Length- Selective Binding Properties
  T. H. Shi, Y. Nagata, S. Akine, S. Ohtani, K. Kato, T. Ogoshi, J. Am. Chem. Soc., 2022, 144, 51, 23677–23684
  DOI: 10.1021/jacs.2c11225
  
• Real-Time Chirality Transfer Monitoring from Statistically Random to Discrete Homochiral Nanotubes
  S. X. Fa, T. H. Shi, S. Akama, K. Adachi, K. Wada, S. Tanaka, N. Oyama, K. Kato, S. Ohtani, Y. Nagata, S. Akine, T. Ogoshi, Nat. Commun., 2022, 13, Article number: 7378
  DOI: 10.1038/s41467-022-34827-z
  
• A Semi-Automated Material Exploration Scheme to Predict the Solubilities of Tetraphenylporphyrin Derivatives
  R. Shirasawa, I. Takemura, S. Hattori, Y. Nagata, Communications Chemistry, 2022, 5, Article number: 158 (2022)
  DOI: 10.1038/s42004-022-00770-9
  
• Quantum Chemical Calculations to Trace Back Reaction Paths for the Prediction of Reactants
  Y. Sumiya, Y. Harabuchi, Y. Nagata, S. Maeda, Jacs Au, 2022, 2, 1181-1188
  DOI: 10.1021/jacsau.2c00157
  
• Preparative-Scale Synthesis of Nonacene
  A. Jancarik, J. Holec, Y. Nagata, M. Samal, A. Gourdon, Nat. Commun., 2022, 13,
  DOI: 10.1038/s41467-021-27809-0
  
• Synthesis, Structure, and Dynamics of Chiral Eight-Membered Cyclic Molecules with Thienylene and Cyclopropylene Units Alternately Connected
  T. Miura, Y. Ishihara, T. Nakamuro, S. Moritani, Y. Nagata, M. Murakami, Chem. Eur. J., 2022, 28,
  DOI: 10.1002/chem.202103962
  
• Young Career Focus: Professor Yuuya Nagata (Hokkaido University, Sapporo, Japan)
  Y. Nagata, Synlett, 2022, 33, A3-A4
  DOI: 10.1055/s-0040-1720546
  

2021

• Cyclodextrins with Multiple Pyrenyl Groups: An Approach to Organic Molecules Exhibiting Bright Excimer Circularly Polarized Luminescence
  H. Shigemitsu, K. Kawakami, Y. Nagata, R. Kajiwara, S. Yamada, T. Mori, T. Kida, Angew. Chem., Int. Ed., 2021, 61,
  DOI: 10.1002/anie.202114700
  
• Alkali Metal Fluorides in Fluorinated Alcohols: Fundamental Properties and Applications to Electrochemical Fluorination
  N. Shida, H. Takenaka, A. Gotou, T. Isogai, A. Yamauchi, Y. Kishikawa, Y. Nagata, I. Tomita, T. Fuchigami, S. Inagi, J. Org. Chem., 2021, 86, 16128-16133
  DOI: 10.1021/acs.joc.1c00692
  
• Tyrosine-Based Photoluminescent Diketopiperazine Supramolecular Aggregates
  N. Shimosaraya, T. Sotani, Y. Miyagi, E. A. Q. Mondarte, K. Suthiwanich, T. Hayashi, Y. Nagata, H. Sogawa, F. Sanda, Soft Matter, 2021, 18, 137-145
  DOI: 10.1039/d1sm01206a
  
• Protected Amino Acids as a Nonbonding Source of Chirality in Induction of Single-Handed Screw-Sense to Helical Macromolecular Catalysts
  S. Ikeda, R. Takeda, T. Fujie, N. Ariki, Y. Nagata, M. Suginome, Chem. Sci., 2021, ,
  DOI: 10.1039/d1sc01764k
  
• Synthesis and Absorption Properties of Long Acenoacenes
  A. Jancarik, D. Mildner, Y. Nagata, M. Banasiewicz, J. Olas, B. Kozankiewicz, J. Holec, A. Gourdon, Chem. Eur. J., 2021, 27, 12388-12394
  DOI: 10.1002/chem.202101577
  
• Pre-Regulation of the Planar Chirality of Pillar 5 Arenes for Preparing Discrete Chiral Nanotubes
  S. X. Fa, K. Adachi, Y. Nagata, K. Egami, K. Kato, T. Ogoshi, Chem. Sci., 2021, 12, 3483-3488
  DOI: 10.1039/d1sc00074h
  
• A Large Starphene Comprising Pentacene Branches
  J. Holec, B. Cogliati, J. Lawrence, A. Berdonces-Layunta, P. Herrero, Y. Nagata, M. Banasiewicz, B. Kozankiewicz, M. Corso, D. G. Oteyza, A. Jancarik, A. Gourdon, Angew. Chem., Int. Ed., 2021, 60, 7752-7758
  DOI: 10.1002/anie.202016163
  
• Stereo- and Enantioselective Synthesis of Propionate-Derived Trisubstituted Alkene Motifs
  T. Miura, N. Oku, Y. Shiratori, Y. Nagata, M. Murakami, Chem. Eur. J., 2021, 27, 3861-3868
  DOI: 10.1002/chem.202004930
  
• Regioselective 1,3-Dipolar Cycloaddition of Nitriles with Nitrile Imines Generated from Tetrazoles
  T. Miura, K. Hagiwara, T. Nakamuro, Y. Nagata, N. Oku, M. Murakami, Chem. Lett., 2021, 50, 131-135
  DOI: 10.1246/cl.200634
  

2020

• Chiral Macrocycles HavingC(3)Symmetry Resulting from Orientation of Thiophene Rings
  T. Miura, T. Nakamuro, Y. Ishihara, Y. Nagata, M. Murakami, Angew. Chem., Int. Ed., 2020, 59, 20475-20479
  DOI: 10.1002/anie.202009781
  
• Holding of Planar Chirality of Pillar 5 Arene by Kinetic Trapping Using Host-Guest Interactions with Achiral Guest Solvents
  Y. Nagata, M. Suzuki, Y. Shimada, H. Sengoku, S. Nishida, T. Kakuta, T. A. Yamagishi, M. Suginome, T. Ogoshi, Chem. Commun., 2020, 56, 8424-8427
  DOI: 10.1039/d0cc03413d
  
• Irreverent Nature of Dissymmetry Factor and Quantum Yield in Circularly Polarized Luminescence of Small Organic Molecules
  Y. Nagata, T. Mori, Frontiers in Chemistry, 2020, 8, 6
  DOI: 10.3389/fchem.2020.00448
  
• Cubane Chirality via Substitution of a "Hidden" Regular Tetrahedron
  N. Yoshino, Y. Kato, T. Mabit, Y. Nagata, C. M. Williams, M. Harada, A. Muranaka, M. Uchiyama, S. Matsubara, Org. Lett., 2020, 22, 4083-4087
  DOI: 10.1021/acs.orglett.0c01142