Hokkaido University

Institute for Chemical Reaction Design and Discovery

2025

• Computational Exploration of Polymer Mechanochemistry: Quantitation of Activation Force and Systematic Discovery of Reaction Sites by the Extended Artificial Force-Induced Reaction Method
  J. Jiang, K. Kubota, Y. Harabuchi, M. Jin, Z. Wang, T. Nakajima, H. Ito, J. Gong, S. Maeda, J. Am. Chem. Soc., 2025, 147, 32502-32521
  DOI: 10.1021/jacs.5c06150
  
• Yielding of Double-Network Hydrogels with Systematically Controlled Tetra-PEG First Networks
  T. Matsuda, N. Kashimura, T. Sakai, T. Nakajima, T. Matsushita, J. Gong, Macromolecules, 2025, 58, 6017-6032
  DOI: 10.1021/acs.macromol.4c02446
  
• Osmosis-Induced Mechanical Disintegration of Polymer Network Gels
  S. Ohmura, K. Oikawa, T. Nishimura, R. Kiyama, J. Gong, T. Nakajima, Small, 2025, ,
  DOI: 10.1002/smll.202503209
  
• Effect of the Second Network on First Network Rupture and the Origin of Energy Dissipation in Double Network Hydrogels
  Z. Wang, G. Wei, T. Nakajima, J. Gong, Macromolecules, 2025, 58, 4835-4846
  DOI: 10.1021/acs.macromol.5c00331
  
• Hydrogels with Prestressed Tensegrity Structures
  B. Xue, X. Han, H. Zhu, Q. Li, Y. Zhang, M. Bai, Y. Li, Y. Li, M. Qin, T. Nakajima, W. Wang, J. Gong, Y. Cao, Nat. Commun., 2025, 16, Article number: 3637
  DOI: 10.1038/s41467-025-58956-3
  
• Mechanochemistry-Induced Universal Hydrogel Surface Modification for Orientation and Enhanced Differentiation of Skeletal Muscle Myoblasts
  Y. Nie, Q. Mu, Y. Sun, Z. Ferdous, L. Wang, C. Chen, T. Nakajima, J. Gong, S. Tanaka, M. Tsuda, ACS APPLIED BIO MATERIALS, 2025, 8, 3144-3155
  DOI: 10.1021/acsabm.4c01991
  
• Rapid Self-Strengthening in Double-Network Hydrogels Triggered by Bond Scission
  Z. Wang, W. Li, X. Li, T. Nakajima, M. Rubinstein, J. Gong, NATURE MATERIALS, 2025, ,
  DOI: 10.1038/s41563-025-02137-6
  
• Double-Network Hydrogels with a Gradient Hydrophobic Coating that Prevents Water Evaporation and Allows Strong Adhesion to a Solid Substrate
  S. Sakurai, T. Kurokawa, H. Furukawa, J. Gong, T. Nakajima, Polymer Journal, 2025, ,
  DOI: 10.1038/s41428-024-01010-8
  

2024

• Tensile Behaviors of Double Network Hydrogels with Varied First Network Topological and Chemical Structures
  F. Lu, T. Nakajima, Y. Zheng, H. Fan, J. Gong, Macromolecules, 2024, ,
  DOI: 10.1021/acs.macromol.4c02087
  
• Gigantic Multilayered Vesicle-like Hydrogel-Bilayer Composites
  N. Horihata, J. Gong, T. Nakajima, Chem. Lett., 2024, 53(11), upae193
  DOI: 10.1093/chemle/upae193
  
• Unique Stick-Slip Crack Dynamics of Double-Network Hydrogels under Pure-Shear Loading
  Y. Zheng, Y. Wang, F. Tian, T. Nakajima, C. Hui, J. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (30), e2322437121
  DOI: 10.1073/pnas.2322437121
  
• Hydrogel Morphogenesis Induced by Force-Controlled Growth
  Z. Wang, J. Lin, T. Nakajima, J. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (27), e2402587121
  DOI: 10.1073/pnas.2402587121
  
• Effect of the Activation Force of Mechanophore on Its Activation Selectivity and Efficiency in Polymer Networks
  Z. J. Wang, S. Wang, J. L. Jiang, Y. X. Hu, T. Nakajima, S. Maeda, S. L. Craig, J. P. Gong, J. Am. Chem. Soc., 2024, 146, 13336-13346
  DOI: 10.1021/jacs.4c01879
  
• Effect of Predamage on the Fracture Energy of Double-Network Hydrogels
  Y. Zheng, Y. R. Wang, T. Nakajima, J. P. Gong, ACS Macro Lett., 2024, ,
  DOI: 10.1021/acsmacrolett.3c00702
  

2023

• Role of Hierarchy Structure on the Mechanical Adaptation of Self-Healing Hydrogels under Cyclic Stretching
  X. Y. Li, K. P. Cui, Y. Zheng, Y. N. Ye, C. T. Yu, W. Q. Yang, T. Nakajima, J. P. Gong, Science Advances, 2023, 9, 51,
  DOI: 10.1126/sciadv.adj6856
  
• Azobenzene as a Photoswitchable Mechanophore
  Y. R. Li, B. Xue, J. H. Yang, J. L. Jiang, J. Liu, Y. Y. Zhou, J. S. Zhang, M. J. Wu, Y. Yuan, Z. S. Zhu, Z. J. Wang, Y. L. Chen, Y. Harabuchi, T. Nakajima, W. Wang, S. Maeda, J. P. Gong, Y. Cao, Nature Chemistry, 2023, ,
  DOI: 10.1038/s41557-023-01389-6
  
• Thermoresponsive Lamellar Hydrogels with Tunable Turbidity, Structural Color, and Anisotropic Swelling
  Y. Han, Y. Z. Guo, T. Nakajima, J. P. Gong, ACS Appl. Mater. Interfaces, 2023, 15, 49, 57687-57698
  DOI: 10.1021/acsami.3c14334
  
• Sustainable Mechanochemical Growth of Double-Network Hydrogels Supported by Vascular-like Perfusion
  G. M. Wei, Y. Kudo, T. Matsuda, Z. J. Wang, Q. F. Mu, D. R. King, T. Nakajima, J. P. Gong, Materials Horizons, 2023, Advance Article,
  DOI: 10.1039/d3mh01038d
  
• Inverse Mechanical-Swelling Coupling of a Highly Deformed Double-Network Gel
  C. Imaoka, T. Nakajima, T. Indei, M. Iwata, W. Hong, A. Marcellan, J. P. Gong, Science Advances, 2023, 9, (19),
  DOI: 10.1126/sciadv.abp8351
  
• Swelling Effect on the Yielding, Elasticity, and Fracture of Double-Network Hydrogels with an Inhomogeneous First Network
  Y. Zheng, T. Nakajima, W. Cui, C. Y. Hui, J. P. Gong, Macromolecules, 2023, 56, 11, 3962-3972
  DOI: 10.1021/acs.macromol.3c00354
  
• Mechanical Model for Super-Anisotropic Swelling of the Multi-Cylindrical PDGI/PAAm Gels
  T. Nakajima, K. Mito, J. P. Gong, Polymers, 2023, 15(7), 1624
  DOI: 10.3390/polym15071624
  
• In Situ and Real-Time Visualization of Mechanochemical Damage in Double-Network Hydrogels by Prefluorescent Probe via Oxygen- Relayed Radical Trapping
  Y. Zheng, J. L. Jiang, M. Jin, D. Miura, F. X. Lu, K. Kubota, T. Nakajima, S. Maeda, H. Ito, J. P. Gong, J. Am. Chem. Soc., 2023, 145, 7376-7389
  DOI: 10.1021/jacs.2c13764
  
• Squid/synthetic Polymer Double-Network Gel: Elaborated Anisotropy and Outstanding Fracture Toughness Characteristics
  S. Ohmura, T. Nakajima, M. Yoshida, J. P. Gong, Npg Asia Materials, 2023, 15, Article number: 2
  DOI: 10.1038/s41427-022-00454-9
  

2022

• Effect of Salt on Dynamic Mechanical Behaviors of Polyampholyte Hydrogels
  X. Y. Li, F. Luo, T. L. Sun, K. P. Cui, R. Watanabe, T. Nakajima, J. P. Gong, Macromolecules, 2022, ,
  DOI: 10.1021/acs.macromol.2c02003
  
• Nanoscale TEM Imaging of Hydrogel Network Architecture
  R. Kiyama, M. Yoshida, T. Nonoyama, T. Sedlacik, H. Jinnai, T. Kurokawa, T. Nakajima, J. P. Gong, Adv. Mater., 2022, ,
  DOI: 10.1002/adma.202208902
  
• Rate-Independent Self-Healing Double Network Hydrogels Using a Thixotropic Sacrificial Network
  T. Yasui, Y. Zheng, T. Nakajima, E. Kamio, H. Matsuyama, J. P. Gong, Macromolecules, 2022, 55, 21, 9547–9557
  DOI: 10.1021/acs.macromol.2c01425
  
• Force-Triggered Rapid Microstructure Growth on Hydrogel Surface for On-Demand Functions
  Q. F. Mu, K. P. Cui, Z. J. Wang, T. Matsuda, W. Cui, H. Kato, S. Namiki, T. Yamazaki, M. Frauenlob, T. Nonoyama, M. Tsuda, S. Tanaka, T. Nakajima, J. P. Gong, Nat. Commun., 2022, 13,
  DOI: 10.1038/s41467-022-34044-8
  
• Surfactant Induced Bilayer-Micelle Transition for Emergence of Functions in Anisotropic Hydrogel
  M. A. Haque, T. Kurokawa, T. Nakajima, G. Kamita, Z. Fatema, J. P. Gong, J. Mater. Chem. B, 2022, ,
  DOI: 10.1039/d2tb00172a
  
• Synthesis of Degradable Double Network Gels Using a Hydrolysable Cross-Linker
  T. Yokoi, A. Kuzuya, T. Nakajima, T. Kurokawa, J. P. Gong, Y. Ohya, Polym. Chem., 2022, 13, 3756-3762
  DOI: 10.1039/d2py00360k
  
• Unique Crack Propagation of Double Network Hydrogels under High Stretch
  Y. Zhang, K. Fukao, T. Matsuda, T. Nakajima, K. Tsunoda, T. Kurokawa, J. P. Gong, Extreme Mechanics Letters, 2022, 51,
  DOI: 10.1016/j.eml.2021.101588
  
• Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation
  Z. J. Wang, J. L. Jiang, Q. F. Mu, S. Maeda, T. Nakajima, J. P. Gong, J. Am. Chem. Soc., 2022, 144, 3154-3161
  DOI: 10.1021/jacs.1c12539
  
• Facile Preparation of Cellulose Hydrogel with Achilles Tendon-like Super Strength through Aligning Hierarchical Fibrous Structure
  Y. Z. Guo, T. Nakajima, M. T. I. Mredha, H. L. Guo, K. P. Cui, Y. Zheng, W. Cui, T. Kurokawa, J. P. Gong, Chemical Engineering Journal, 2022, 428,
  DOI: 10.1016/j.cej.2021.132040
  

2021

• How Chain Dynamics Affects Crack Initiation in Double-Network Gels
  Y. Zheng, T. Matsuda, T. Nakajima, W. Cui, Y. Zhang, C. Y. Hui, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118,
  DOI: 10.1073/pnas.2111880118
  
• Revisiting the Origins of the Fracture Energy of Tough Double-Network Hydrogels with Quantitative Mechanochemical Characterization of the Damage Zone
  T. Matsuda, R. Kawakami, T. Nakajima, Y. Hane, J. P. Gong, Macromolecules, 2021, 54, 10331-10339
  DOI: 10.1021/acs.macromol.1c01214
  
• Experimental Verification of the Balance between Elastic Pressure and Ionic Osmotic Pressure of Highly Swollen Charged Gels
  T. Nakajima, K. Hoshino, H. L. Guo, T. Kurokawa, J. P. Gong, Gels, 2021, 7,
  DOI: 10.3390/gels7020039
  
• Nanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance
  Y. Zheng, R. Kiyama, T. Matsuda, K. P. Cui, X. Y. Li, W. Cui, Y. Z. Guo, T. Nakajima, T. Kurokawa, J. P. Gong, Chem. Mater., 2021, 33, 3321-3334
  DOI: 10.1021/acs.chemmater.1c00512
  
• Molecular Mechanism of Abnormally Large Nonsoftening Deformation in a Tough Hydrogel
  Y. N. Ye, K. P. Cui, W. Hong, X. Y. Li, C. T. Yu, D. Hourdet, T. Nakajima, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, 5
  DOI: 10.1073/pnas.2014694118
  

2020

• Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
  J. C. Huang, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
  DOI: 10.1021/acs.biomac.0c01033
  
• Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization
  T. Matsuda, R. Kawakami, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 8787-8795
  DOI: 10.1021/acs.macromol.0c01485
  
• Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
  T. Sedlacik, T. Nonoyama, H. L. Guo, R. Kiyama, T. Nakajima, Y. Takeda, T. Kurokawa, J. P. Gong, Chem. Mater., 2020, 32, 8576-8586
  DOI: 10.1021/acs.chemmater.0c02911
  
• Effect of the Constituent Networks of Double-Network Gels on Their Mechanical Properties and Energy Dissipation Process
  T. Nakajima, T. Kurokawa, H. Furukawa, J. P. Gong, Soft Matter, 2020, 16, 8618-8627
  DOI: 10.1039/d0sm01057j
  
• Lamellar Bilayer to Fibril Structure Transformation of Tough Photonic Hydrogel under Elongation
  M. A. Haque, K. P. Cui, M. Ilyas, T. Kurokawa, A. Marcellan, A. Brulet, R. Takahashi, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 4711-4721
  DOI: 10.1021/acs.macromol.0c00878
  
• Double-Network Gels as Polyelectrolyte Gels with Salt-Insensitive Swelling Properties
  T. Nakajima, T. Chida, K. Mito, T. Kurokawa, J. P. Gong, Soft Matter, 2020, 16, 5487-5496
  DOI: 10.1039/d0sm00605j
  
• Effect of Relative Strength of Two Networks on the Internal Fracture Process of Double Network Hydrogels As Revealed by in Situ Small-Angle X-Ray Scattering
  K. Fukao, T. Nakajima, T. Nonoyama, T. Kurokawa, T. Kawai, J. P. Gong, Macromolecules, 2020, 53, 1154-1163
  DOI: 10.1021/acs.macromol.9b02562
  

2019

• Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
  HL. Guo, W. Hong, T. Kurokawa, T. Matsuda, ZL. Wu, T. Nakajima, M. Takahata, TL. Sun, P. Rao, JP. Gong, Macromolecules, 2019, 52, 7114-7122
  DOI: 10.1021/acs.macromol.9b01308
  
• Hydrophobic Hydrogels with Fruit-Like Structure and Functions
  H. Guo, T. Nakajima, D. Hourdet, A. Marcellan, C. Creton, W. Hong, T. Kurokawa, JP. Gong, Adv. Mater., 2019, 31, 1900702
  DOI: 10.1002/adma.201900702
  
• Damage Cross-Effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
  TT. Mai, T. Matsuda, T. Nakajima, JP. Gong, K. Urayama, Soft Matter, 2019, 15, 3719-3732
  DOI: 10.1039/c9sm00409b
  
• Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
  T. Matsuda, T. Nakajima, JP. Gong, Chem. Mater., 2019, 31, 3766-3776
  DOI: 10.1021/acs.chemmater.9b00871
  
• Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
  J. Murat, T. Nakajima, T. Matsuda, K. Tsunoda, T. Nonoyama, T. Kurokawa, JP. Gong, Polymer, 2019, 178, 121686
  DOI: 10.1016/j.polymer.2019.121686
  
• Tough Double-Network Gels and Elastomers from the Nonprestretched First Network
  T. Nakajima, Y. Ozaki, R. Namba, K. Ota, Y. Maida, T. Matsuda, T. Kurokawa, JP. Gong, ACS Macro Lett., 2019, 8, 1407-1412
  DOI: 10.1021/acsmacrolett.9b00679
  
• Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
  YN. Ye, KP. Cui, T. Indei, T. Nakajima, D. Hourdet, T. Kurokawa, JP. Gong, Macromolecules, 2019, 52, 8651-8661
  DOI: 10.1021/acs.macromol.9b01856
  

2018

• Network Elasticity of a Model Hydrogel as a Function of Swelling Ratio: From Shrinking to Extreme Swelling States
  K. Hoshino, T. Nakajima, T. Matsuda, T. Sakai, JP. Gong, Soft Matter, 2018, 14, 9693-9701
  DOI: 10.1039/c8sm01854e