中島 祐

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中島 祐
准教授
北海道大学大学院先端生命科学研究院
関連ウェブサイト
連絡先

tasuku atmark sci.hokudai.ac.jp

グン・チェンピン グループ
主任研究者
教員
博士研究員
研究協力者
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    中島 祐
スタッフ
  • 羽根 由貴子

研究紹介

研究テーマ

ゲルと化学反応の相互触発による材料機能の開拓

キーワード

高分子物理、機能性ゲル、メカノケミストリー
研究概要

ゲル材料を特殊な反応場とした化学反応の開発と、その化学反応によるゲル材料の更なる機能化、高強度化を進めています。一例として、力学的負荷を加えるごとに強度やサイズが大きくなる、まるで筋肉のような自己成長材料を創製しています。

代表的な研究成果

  • Mechanoresponsive Self-growing Hydrogels Inspired by Muscle Training
    T. Matsuda, R. Kawakami, R. Namba, T. Nakajima, J. P. Gong
    Science, 2019, 363, 504-508
    DOI: 10.1126/science.aau9533
  • Hydrophobic Hydrogels with Fruit‐Like Structure and Functions
    H. Guo, T. Nakajima, D. Hourdet, A. Marcellan, C. Creton, W. Hong, T. Kurokawa, J. P. Gong
    Adv. Mater., 2019, 31, 1900702
    DOI: 10.1002/adma.201900702
  • Network Elasticity of a Model Hydrogel as a Function of Swelling Ratio: From Shrinking to Extreme Swelling State
    K.-I. Hoshino, T. Nakajima, T. Matsuda, T. Sakai, J. P. Gong
    Soft Matter, 2018, 14, 9693-9701
    DOI: 10.1039/C8SM01854E
  • Phase Separation-Induced Anomalous Stiffening, Toughening, and Self-healing of Polyacrylamide Gels
    K. Sato, T. Nakajima, T. Hisamatsu, T. Nonoyama, T. Kurokawa, J. P. Gong
    Adv. Mater., 2015, 27, 6990-6998
    DOI: 10.1002/adma.201502967
  • A Universal Molecular Stent Method to Toughen any Hydrogels Based on Double Network Concept
    T. Nakajima, H. Sato, Y. Zhao, S. Kawahara, T. Kurokawa, K. Sugahara, J. P. Gong
    Adv. Funct. Mater., 2012, 22, 4426-4432
    DOI: 10.1002/adfm.201200809

関連する研究記事

業績一覧

2024年

  • Hydrogel Morphogenesis Induced by Force- Controlled Growth
    Z. Wang, J. Lin, T. Nakajima, J. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121,
    DOI: 10.1073/pnas.2402587121
  • Effect of the Activation Force of Mechanophore on Its Activation Selectivity and Efficiency in Polymer Networks
    Z. J. Wang, S. Wang, J. L. Jiang, Y. X. Hu, T. Nakajima, S. Maeda, S. L. Craig, J. P. Gong, J. Am. Chem. Soc., 2024, 146, 13336-13346
    DOI: 10.1021/jacs.4c01879
  • Effect of Predamage on the Fracture Energy of Double-Network Hydrogels
    Y. Zheng, Y. R. Wang, T. Nakajima, J. P. Gong, ACS Macro Lett., 2024, ,
    DOI: 10.1021/acsmacrolett.3c00702

2023年

  • Role of Hierarchy Structure on the Mechanical Adaptation of Self-Healing Hydrogels under Cyclic Stretching
    X. Y. Li, K. P. Cui, Y. Zheng, Y. N. Ye, C. T. Yu, W. Q. Yang, T. Nakajima, J. P. Gong, Science Advances, 2023, 9, 51,
    DOI: 10.1126/sciadv.adj6856
  • Azobenzene as a Photoswitchable Mechanophore
    Y. R. Li, B. Xue, J. H. Yang, J. L. Jiang, J. Liu, Y. Y. Zhou, J. S. Zhang, M. J. Wu, Y. Yuan, Z. S. Zhu, Z. J. Wang, Y. L. Chen, Y. Harabuchi, T. Nakajima, W. Wang, S. Maeda, J. P. Gong, Y. Cao, Nature Chemistry, 2023, ,
    DOI: 10.1038/s41557-023-01389-6
  • Thermoresponsive Lamellar Hydrogels with Tunable Turbidity, Structural Color, and Anisotropic Swelling
    Y. Han, Y. Z. Guo, T. Nakajima, J. P. Gong, ACS Appl. Mater. Interfaces, 2023, 15, 49, 57687-57698
    DOI: 10.1021/acsami.3c14334
  • Sustainable Mechanochemical Growth of Double-Network Hydrogels Supported by Vascular-like Perfusion
    G. M. Wei, Y. Kudo, T. Matsuda, Z. J. Wang, Q. F. Mu, D. R. King, T. Nakajima, J. P. Gong, Materials Horizons, 2023, Advance Article,
    DOI: 10.1039/d3mh01038d
  • Inverse Mechanical-Swelling Coupling of a Highly Deformed Double-Network Gel
    C. Imaoka, T. Nakajima, T. Indei, M. Iwata, W. Hong, A. Marcellan, J. P. Gong, Science Advances, 2023, 9, (19),
    DOI: 10.1126/sciadv.abp8351
  • Swelling Effect on the Yielding, Elasticity, and Fracture of Double-Network Hydrogels with an Inhomogeneous First Network
    Y. Zheng, T. Nakajima, W. Cui, C. Y. Hui, J. P. Gong, Macromolecules, 2023, 56, 11, 3962-3972
    DOI: 10.1021/acs.macromol.3c00354
  • Mechanical Model for Super-Anisotropic Swelling of the Multi-Cylindrical PDGI/PAAm Gels
    T. Nakajima, K. Mito, J. P. Gong, Polymers, 2023, 15(7), 1624
    DOI: 10.3390/polym15071624
  • In Situ and Real-Time Visualization of Mechanochemical Damage in Double-Network Hydrogels by Prefluorescent Probe via Oxygen- Relayed Radical Trapping
    Y. Zheng, J. L. Jiang, M. Jin, D. Miura, F. X. Lu, K. Kubota, T. Nakajima, S. Maeda, H. Ito, J. P. Gong, J. Am. Chem. Soc., 2023, 145, 7376-7389
    DOI: 10.1021/jacs.2c13764
  • Squid/synthetic Polymer Double-Network Gel: Elaborated Anisotropy and Outstanding Fracture Toughness Characteristics
    S. Ohmura, T. Nakajima, M. Yoshida, J. P. Gong, Npg Asia Materials, 2023, 15, Article number: 2
    DOI: 10.1038/s41427-022-00454-9

2022年

  • Effect of Salt on Dynamic Mechanical Behaviors of Polyampholyte Hydrogels
    X. Y. Li, F. Luo, T. L. Sun, K. P. Cui, R. Watanabe, T. Nakajima, J. P. Gong, Macromolecules, 2022, ,
    DOI: 10.1021/acs.macromol.2c02003
  • Nanoscale TEM Imaging of Hydrogel Network Architecture
    R. Kiyama, M. Yoshida, T. Nonoyama, T. Sedlacik, H. Jinnai, T. Kurokawa, T. Nakajima, J. P. Gong, Adv. Mater., 2022, ,
    DOI: 10.1002/adma.202208902
  • Rate-Independent Self-Healing Double Network Hydrogels Using a Thixotropic Sacrificial Network
    T. Yasui, Y. Zheng, T. Nakajima, E. Kamio, H. Matsuyama, J. P. Gong, Macromolecules, 2022, 55, 21, 9547–9557
    DOI: 10.1021/acs.macromol.2c01425
  • Force-Triggered Rapid Microstructure Growth on Hydrogel Surface for On-Demand Functions
    Q. F. Mu, K. P. Cui, Z. J. Wang, T. Matsuda, W. Cui, H. Kato, S. Namiki, T. Yamazaki, M. Frauenlob, T. Nonoyama, M. Tsuda, S. Tanaka, T. Nakajima, J. P. Gong, Nat. Commun., 2022, 13,
    DOI: 10.1038/s41467-022-34044-8
  • Surfactant Induced Bilayer-Micelle Transition for Emergence of Functions in Anisotropic Hydrogel
    M. A. Haque, T. Kurokawa, T. Nakajima, G. Kamita, Z. Fatema, J. P. Gong, J. Mater. Chem. B, 2022, ,
    DOI: 10.1039/d2tb00172a
  • Synthesis of Degradable Double Network Gels Using a Hydrolysable Cross-Linker
    T. Yokoi, A. Kuzuya, T. Nakajima, T. Kurokawa, J. P. Gong, Y. Ohya, Polym. Chem., 2022, 13, 3756-3762
    DOI: 10.1039/d2py00360k
  • Unique Crack Propagation of Double Network Hydrogels under High Stretch
    Y. Zhang, K. Fukao, T. Matsuda, T. Nakajima, K. Tsunoda, T. Kurokawa, J. P. Gong, Extreme Mechanics Letters, 2022, 51,
    DOI: 10.1016/j.eml.2021.101588
  • Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation
    Z. J. Wang, J. L. Jiang, Q. F. Mu, S. Maeda, T. Nakajima, J. P. Gong, J. Am. Chem. Soc., 2022, 144, 3154-3161
    DOI: 10.1021/jacs.1c12539
  • Facile Preparation of Cellulose Hydrogel with Achilles Tendon-like Super Strength through Aligning Hierarchical Fibrous Structure
    Y. Z. Guo, T. Nakajima, M. T. I. Mredha, H. L. Guo, K. P. Cui, Y. Zheng, W. Cui, T. Kurokawa, J. P. Gong, Chemical Engineering Journal, 2022, 428,
    DOI: 10.1016/j.cej.2021.132040

2021年

  • How Chain Dynamics Affects Crack Initiation in Double-Network Gels
    Y. Zheng, T. Matsuda, T. Nakajima, W. Cui, Y. Zhang, C. Y. Hui, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118,
    DOI: 10.1073/pnas.2111880118
  • Revisiting the Origins of the Fracture Energy of Tough Double-Network Hydrogels with Quantitative Mechanochemical Characterization of the Damage Zone
    T. Matsuda, R. Kawakami, T. Nakajima, Y. Hane, J. P. Gong, Macromolecules, 2021, 54, 10331-10339
    DOI: 10.1021/acs.macromol.1c01214
  • Experimental Verification of the Balance between Elastic Pressure and Ionic Osmotic Pressure of Highly Swollen Charged Gels
    T. Nakajima, K. Hoshino, H. L. Guo, T. Kurokawa, J. P. Gong, Gels, 2021, 7,
    DOI: 10.3390/gels7020039
  • Nanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance
    Y. Zheng, R. Kiyama, T. Matsuda, K. P. Cui, X. Y. Li, W. Cui, Y. Z. Guo, T. Nakajima, T. Kurokawa, J. P. Gong, Chem. Mater., 2021, 33, 3321-3334
    DOI: 10.1021/acs.chemmater.1c00512
  • Molecular Mechanism of Abnormally Large Nonsoftening Deformation in a Tough Hydrogel
    Y. N. Ye, K. P. Cui, W. Hong, X. Y. Li, C. T. Yu, D. Hourdet, T. Nakajima, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, 5
    DOI: 10.1073/pnas.2014694118

2020年

  • Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
    J. C. Huang, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
    DOI: 10.1021/acs.biomac.0c01033
  • Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization
    T. Matsuda, R. Kawakami, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 8787-8795
    DOI: 10.1021/acs.macromol.0c01485
  • Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
    T. Sedlacik, T. Nonoyama, H. L. Guo, R. Kiyama, T. Nakajima, Y. Takeda, T. Kurokawa, J. P. Gong, Chem. Mater., 2020, 32, 8576-8586
    DOI: 10.1021/acs.chemmater.0c02911
  • Effect of the Constituent Networks of Double-Network Gels on Their Mechanical Properties and Energy Dissipation Process
    T. Nakajima, T. Kurokawa, H. Furukawa, J. P. Gong, Soft Matter, 2020, 16, 8618-8627
    DOI: 10.1039/d0sm01057j
  • Lamellar Bilayer to Fibril Structure Transformation of Tough Photonic Hydrogel under Elongation
    M. A. Haque, K. P. Cui, M. Ilyas, T. Kurokawa, A. Marcellan, A. Brulet, R. Takahashi, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 4711-4721
    DOI: 10.1021/acs.macromol.0c00878
  • Double-Network Gels as Polyelectrolyte Gels with Salt-Insensitive Swelling Properties
    T. Nakajima, T. Chida, K. Mito, T. Kurokawa, J. P. Gong, Soft Matter, 2020, 16, 5487-5496
    DOI: 10.1039/d0sm00605j
  • Effect of Relative Strength of Two Networks on the Internal Fracture Process of Double Network Hydrogels As Revealed by in Situ Small-Angle X-Ray Scattering
    K. Fukao, T. Nakajima, T. Nonoyama, T. Kurokawa, T. Kawai, J. P. Gong, Macromolecules, 2020, 53, 1154-1163
    DOI: 10.1021/acs.macromol.9b02562

2019年

  • Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
    HL. Guo, W. Hong, T. Kurokawa, T. Matsuda, ZL. Wu, T. Nakajima, M. Takahata, TL. Sun, P. Rao, JP. Gong, Macromolecules, 2019, 52, 7114-7122
    DOI: 10.1021/acs.macromol.9b01308
  • Hydrophobic Hydrogels with Fruit-Like Structure and Functions
    H. Guo, T. Nakajima, D. Hourdet, A. Marcellan, C. Creton, W. Hong, T. Kurokawa, JP. Gong, Adv. Mater., 2019, 31, 1900702
    DOI: 10.1002/adma.201900702
  • Damage Cross-Effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
    TT. Mai, T. Matsuda, T. Nakajima, JP. Gong, K. Urayama, Soft Matter, 2019, 15, 3719-3732
    DOI: 10.1039/c9sm00409b
  • Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
    T. Matsuda, T. Nakajima, JP. Gong, Chem. Mater., 2019, 31, 3766-3776
    DOI: 10.1021/acs.chemmater.9b00871
  • Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
    J. Murat, T. Nakajima, T. Matsuda, K. Tsunoda, T. Nonoyama, T. Kurokawa, JP. Gong, Polymer, 2019, 178, 121686
    DOI: 10.1016/j.polymer.2019.121686
  • Tough Double-Network Gels and Elastomers from the Nonprestretched First Network
    T. Nakajima, Y. Ozaki, R. Namba, K. Ota, Y. Maida, T. Matsuda, T. Kurokawa, JP. Gong, ACS Macro Lett., 2019, 8, 1407-1412
    DOI: 10.1021/acsmacrolett.9b00679
  • Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
    YN. Ye, KP. Cui, T. Indei, T. Nakajima, D. Hourdet, T. Kurokawa, JP. Gong, Macromolecules, 2019, 52, 8651-8661
    DOI: 10.1021/acs.macromol.9b01856

2018年

  • Network Elasticity of a Model Hydrogel as a Function of Swelling Ratio: From Shrinking to Extreme Swelling States
    K. Hoshino, T. Nakajima, T. Matsuda, T. Sakai, JP. Gong, Soft Matter, 2018, 14, 9693-9701
    DOI: 10.1039/c8sm01854e