龔 剣萍（グン・チェンピン）

thumbnail image
龔 剣萍（グン・チェンピン）
主任研究者, 教授
北海道大学
研究分野
高分子科学, ソフトマター, ゲル科学
関連ウェブサイト
連絡先

gong atmark sci.hokudai.ac.jp

グン・チェンピン グループ
主任研究者
  • thumbnail image
    龔 剣萍（グン・チェンピン）
教員
博士研究員
研究協力者
スタッフ
  • 羽根 由貴子

研究紹介

研究テーマ

高機能ゲルやソフトマターの開発。特に高強度ゲル、自己進化ゲル、低摩擦ゲル、高接着ゲル、生体適合ゲルの開発

キーワード

高分子ゲル, 生体代替材料, 再生医療

研究概要

私たちの最終目標は、筋肉、軟骨、腱などの生体軟部組織と比較して、より強靭で高機能なゲルを開発することです。このゲルの医療分野などへの応用を行っていきたいと考えています。そのため、ICReDDでは、分子レベルでの設計にもとづく代謝能や自己成長機構を有した物質を作り出すことを目指しています。

これらのために、生体系における機能について、実際の生体系からヒントを得て仮説を立てます。その仮説をもとに、生体機能と同等もしくはより優れた特性を持つ化合物を合成します。それを用いて前述の仮説を検証し、合成した化合物の物理的特性を調べます。この検証結果から次の仮説を立て、改良を加えていきます。

研究者の思い

科学者というのはある意味とてもユニークな職業です。アーティストのように、創造性とひたむきさが必要で、自分の興味をとことん追求していくからです。何かを発見したり創り出したときには、この上ない喜びを感じることができます。私が科学者に興味をもつようになった理由の一つは、子どもの頃に研究者、特にマリー・キュリーの伝記を読んだからです。女性にとって多くの困難を伴った時代にこれほどの成果をあげた女性がいたことに小さな私はとても心を動かされました。今日でさえ化学の分野で博士課程に進む女子学生や女性化学者はまだまだ少ないので、もっと増えてくれたらいいと思っています。

MANABIYAコースの研修内容はこちらです。MANABIYA全般について詳しく知りたい方は、こちらをクリックしてください。

代表的な研究成果

  • Double Network Hydrogels with Extremely High Mechanical Strength
    J. P. Gong, Y. Katsuyama, T. Kurokawa, Y. Osada, Adv. Mat., 2003, 15, 1155-1158
    DOI : 10.1002/adma.200304907
  • Why Are Double Network Hydrogels So Tough?
    J. P. Gong, Soft Mater., 2010, 6, 2583-2590
    DOI : 10.1039/B924290B
  • Physical Hydrogels Composed of Polyampholytes Demonstrate High Toughness and Viscoelasticity
    T. L. Sun, T. Kurokawa, S. Kuroda, A. B. Ihsan, T. Akasaki, K. Sato, Md. A. Haque, T. Nakajima, J. P. Gong, Nat. Mater., 2013, 12, 932-937
    DOI : 10.1038/nmat3713
  • Large Strain Hysteresis and Mullins Effect of Tough Double-Network Hydrogels
    R. E. Webber, C. Creton, H. R. Brown, J. P. Gong, Macromolecules, 2007, 40, 2919-2917
    DOI : 10.1021/ma062924y
  • Super Tough Double Network Hydrogels and Their Application as Biomaterials
    Md. A. Haque, T. Kurokawa, J. P. Gong, Polymer, 2012, 53, 1805-1822
    DOI : 10.1016/j.polymer.2012.03.013
  • Tough Hydrogels with Fast, Strong, and Reversible Underwater Adhesion Based on a Multi-Scale Design
    Ping Rao, Tao Lin Sun, Liang Chen, Riku Takahashi, Gento Shinohara, Hui Guo, Daniel R. King, Takayuki Kurokawa, Jian Ping Gong, Advanced Materials, 2018, 30(32), 1801884
    DOI : 10.1002/adma.201801884
  • Mechanoresponsive self-growing hydrogels inspired by muscle training
    Takahiro Matsuda et al., Science, 2019, 363(6426), 504-508
    DOI : 10.1126/science.aau9533

関連する研究記事

業績一覧

2024年

  • Tough Hydroxyapatite Hydrogels Based on Bone-like Self-Regulatory Sacrificial Bond Formation
    N. Kashimura, Y. Suzuki, T. Nonoyama, J. P. Gong, Chem. Mater., 2024, ,
    DOI: 10.1021/acs.chemmater.3c03272
  • Effect of Predamage on the Fracture Energy of Double-Network Hydrogels
    Y. Zheng, Y. R. Wang, T. Nakajima, J. P. Gong, ACS Macro Lett., 2024, ,
    DOI: 10.1021/acsmacrolett.3c00702

2023年

  • Role of Hierarchy Structure on the Mechanical Adaptation of Self-Healing Hydrogels under Cyclic Stretching
    X. Y. Li, K. P. Cui, Y. Zheng, Y. N. Ye, C. T. Yu, W. Q. Yang, T. Nakajima, J. P. Gong, Science Advances, 2023, 9, 51,
    DOI: 10.1126/sciadv.adj6856
  • Azobenzene as a Photoswitchable Mechanophore
    Y. R. Li, B. Xue, J. H. Yang, J. L. Jiang, J. Liu, Y. Y. Zhou, J. S. Zhang, M. J. Wu, Y. Yuan, Z. S. Zhu, Z. J. Wang, Y. L. Chen, Y. Harabuchi, T. Nakajima, W. Wang, S. Maeda, J. P. Gong, Y. Cao, Nature Chemistry, 2023, ,
    DOI: 10.1038/s41557-023-01389-6
  • Thermoresponsive Lamellar Hydrogels with Tunable Turbidity, Structural Color, and Anisotropic Swelling
    Y. Han, Y. Z. Guo, T. Nakajima, J. P. Gong, ACS Appl. Mater. Interfaces, 2023, 15, 49, 57687-57698
    DOI: 10.1021/acsami.3c14334
  • Fractographic Mirror Law for Brittle Fracture of Nonlinear Elastic Soft Materials
    R. Kiyama, Y. Zheng, T. Nonoyama, J. P. Gong, Soft Matter, 2023, ,
    DOI: 10.1039/D3SM00879G
  • Sustainable Mechanochemical Growth of Double-Network Hydrogels Supported by Vascular-like Perfusion
    G. M. Wei, Y. Kudo, T. Matsuda, Z. J. Wang, Q. F. Mu, D. R. King, T. Nakajima, J. P. Gong, Materials Horizons, 2023, Advance Article,
    DOI: 10.1039/d3mh01038d
  • Mechanical Reinforcement of Lamellar Bilayer Hydrogels by Small Amounts of Co-Surfactants
    M. Lama, J. P. Gong, Acs Omega, 2023, 8, 28, 25185–25194
    DOI: 10.1021/acsomega.3c02274
  • Origin of Surface Charge of Double Network Hydrogels Prepared by Sequential Polymerization
    M. Frauenlob, H. L. Guo, T. Kurokawa, J. P. Gong, ACS Macro Lett., 2023, 12, 860–865
    DOI: 10.1021/acsmacrolett.3c00160
  • Inverse Mechanical-Swelling Coupling of a Highly Deformed Double-Network Gel
    C. Imaoka, T. Nakajima, T. Indei, M. Iwata, W. Hong, A. Marcellan, J. P. Gong, Science Advances, 2023, 9, (19),
    DOI: 10.1126/sciadv.abp8351
  • Swelling Effect on the Yielding, Elasticity, and Fracture of Double-Network Hydrogels with an Inhomogeneous First Network
    Y. Zheng, T. Nakajima, W. Cui, C. Y. Hui, J. P. Gong, Macromolecules, 2023, 56, 11, 3962-3972
    DOI: 10.1021/acs.macromol.3c00354
  • Mechanical Model for Super-Anisotropic Swelling of the Multi-Cylindrical PDGI/PAAm Gels
    T. Nakajima, K. Mito, J. P. Gong, Polymers, 2023, 15(7), 1624
    DOI: 10.3390/polym15071624
  • In Situ and Real-Time Visualization of Mechanochemical Damage in Double-Network Hydrogels by Prefluorescent Probe via Oxygen- Relayed Radical Trapping
    Y. Zheng, J. L. Jiang, M. Jin, D. Miura, F. X. Lu, K. Kubota, T. Nakajima, S. Maeda, H. Ito, J. P. Gong, J. Am. Chem. Soc., 2023, 145, 7376-7389
    DOI: 10.1021/jacs.2c13764
  • Relaxation Mechanisms in Hydrogels with Uniaxially Oriented Lamellar Bilayers
    A. Giustiniani, M. Ilyas, T. Indei, J. P. Gong, Polymer, 2023, 267,
    DOI: 10.1016/j.polymer.2023.125686
  • Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction
    Tanikawa, S, Ebisu, Y, Sedlacík, T, Semba, S, Nonoyama, T, Kurokawa, T, Hirota, A, Takahashi, T, Yamaguchi, K, Imajo, M, Kato, H, Nishimura, T, Tanei, ZI, Tsuda, M, Nemoto, T, Gong, JP, Tanaka, S, Scientific Reports, 2023, 13, (1), Article number: 2233
    DOI: 10.1038/s41598-023-28870-z
  • Load Transfer between Permanent and Dynamic Networks Due to Stress Gradients in Nonlinear Viscoelastic Hydrogels
    J. K. Wang, K. P. Cui, B. G. Zhu, J. P. Gong, C. Y. Hui, A. T. Zehnder, Extreme Mechanics Letters, 2023, 58,
    DOI: 10.1016/j.eml.2022.101928
  • Squid/synthetic Polymer Double-Network Gel: Elaborated Anisotropy and Outstanding Fracture Toughness Characteristics
    S. Ohmura, T. Nakajima, M. Yoshida, J. P. Gong, Npg Asia Materials, 2023, 15, Article number: 2
    DOI: 10.1038/s41427-022-00454-9
  • Geometrical Analysis Identified Morphological Features of Hydrogel- Induced Cancer Stem Cells in Synovial Sarcoma Model Cells
    Z. Ferdous, J. E. Clement, J. P. Gong, S. Tanaka, T. Komatsuzaki, M. Tsuda, Biochemical and Biophysical Research Communications, 2023, 642, 41-49
    DOI: 10.1016/j.bbrc.2022.12.040

2022年

  • Effect of Salt on Dynamic Mechanical Behaviors of Polyampholyte Hydrogels
    X. Y. Li, F. Luo, T. L. Sun, K. P. Cui, R. Watanabe, T. Nakajima, J. P. Gong, Macromolecules, 2022, ,
    DOI: 10.1021/acs.macromol.2c02003
  • ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells
    A. Hirota, J. E. Clement, S. Tanikawa, T. Nonoyama, T. Komatsuzaki, J. P. Gong, S. Tanaka, M. Imajo, Cancers, 2022, 14,
    DOI: 10.3390/cancers14235890
  • Nanoscale TEM Imaging of Hydrogel Network Architecture
    R. Kiyama, M. Yoshida, T. Nonoyama, T. Sedlacik, H. Jinnai, T. Kurokawa, T. Nakajima, J. P. Gong, Adv. Mater., 2022, ,
    DOI: 10.1002/adma.202208902
  • How Double Dynamics Affects the Large Deformation and Fracture Behaviors of Soft Materials
    K. P. Cui, J. P. Gong, Journal of Rheology, 2022, 66, 1093-1111
    DOI: 10.1122/8.0000438
  • Gluing Blood into Gel by Electrostatic Interaction Using a Water-Soluble Polymer as an Embolic Agent
    Z. P. Jin, H. L. Fan, T. Osanai, T. Nonoyama, T. Kurokawa, H. Hyodoh, K. Matoba, A. Takeuchi, J. P. Gong, M. Fujimura, Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (42), e2206685119
    DOI: 10.1073/pnas.2206685119
  • Rate-Independent Self-Healing Double Network Hydrogels Using a Thixotropic Sacrificial Network
    T. Yasui, Y. Zheng, T. Nakajima, E. Kamio, H. Matsuyama, J. P. Gong, Macromolecules, 2022, 55, 21, 9547–9557
    DOI: 10.1021/acs.macromol.2c01425
  • Force-Triggered Rapid Microstructure Growth on Hydrogel Surface for On-Demand Functions
    Q. F. Mu, K. P. Cui, Z. J. Wang, T. Matsuda, W. Cui, H. Kato, S. Namiki, T. Yamazaki, M. Frauenlob, T. Nonoyama, M. Tsuda, S. Tanaka, T. Nakajima, J. P. Gong, Nat. Commun., 2022, 13,
    DOI: 10.1038/s41467-022-34044-8
  • Mechanism of Temperature-Induced Asymmetric Swelling and Shrinking Kinetics in Self-Healing Hydrogels
    K. P. Cui, C. T. Yu, Y. N. Ye, X. Y. Li, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2022, 119,
    DOI: 10.1073/pnas.220742211
  • Surfactant Induced Bilayer-Micelle Transition for Emergence of Functions in Anisotropic Hydrogel
    M. A. Haque, T. Kurokawa, T. Nakajima, G. Kamita, Z. Fatema, J. P. Gong, J. Mater. Chem. B, 2022, ,
    DOI: 10.1039/d2tb00172a
  • Synthesis of Degradable Double Network Gels Using a Hydrolysable Cross-Linker
    T. Yokoi, A. Kuzuya, T. Nakajima, T. Kurokawa, J. P. Gong, Y. Ohya, Polym. Chem., 2022, 13, 3756-3762
    DOI: 10.1039/d2py00360k
  • Role of Dynamic Bonds on Fatigue Threshold of Tough Hydrogels
    X. Y. Li, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2022, 119,
    DOI: 10.1073/pnas.2200678119
  • Evaluation of Biological Responses to Micro-Particles Derived from a Double Network Hydrogel
    G. Matsumae, M. A. Terkawi, T. Nonoyama, T. Kurokawa, D. Takahashi, T. Shimizu, K. Kadoya, J. P. Gong, K. Yasuda, N. Iwasaki, Biomaterials Science, 2022, 10, 2182-2187
    DOI: 10.1039/d1bm01777b
  • Quantitative Determination of Cation-Pi Interactions between Metal Ions and Aromatic Groups in Aqueous Media by a Hydrogel Donnan Potential Method
    H. L. Fan, H. L. Guo, T. Kurokawa, J. P. Gong, Phys. Chem. Chem. Phys., 2022, 24, 6126-6132
    DOI: 10.1039/d1cp05622k
  • Unique Crack Propagation of Double Network Hydrogels under High Stretch
    Y. Zhang, K. Fukao, T. Matsuda, T. Nakajima, K. Tsunoda, T. Kurokawa, J. P. Gong, Extreme Mechanics Letters, 2022, 51,
    DOI: 10.1016/j.eml.2021.101588
  • Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation
    Z. J. Wang, J. L. Jiang, Q. F. Mu, S. Maeda, T. Nakajima, J. P. Gong, J. Am. Chem. Soc., 2022, 144, 3154-3161
    DOI: 10.1021/jacs.1c12539
  • Facile Preparation of Cellulose Hydrogel with Achilles Tendon-like Super Strength through Aligning Hierarchical Fibrous Structure
    Y. Z. Guo, T. Nakajima, M. T. I. Mredha, H. L. Guo, K. P. Cui, Y. Zheng, W. Cui, T. Kurokawa, J. P. Gong, Chemical Engineering Journal, 2022, 428,
    DOI: 10.1016/j.cej.2021.132040

2021年

  • In Situ Evaluation of the Polymer Concentration Distribution of Microphase-Separated Polyelectrolyte Hydrogels by the Microelectrode Technique
    T. Nishimura, H. L. Guo, R. Kiyama, Y. Katsuyama, J. P. Gong, T. Kurokawa, Macromolecules, 2021, 54, 10776-10785
    DOI: 10.1021/acs.macromol.1c01435
  • How Chain Dynamics Affects Crack Initiation in Double-Network Gels
    Y. Zheng, T. Matsuda, T. Nakajima, W. Cui, Y. Zhang, C. Y. Hui, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118,
    DOI: 10.1073/pnas.2111880118
  • Revisiting the Origins of the Fracture Energy of Tough Double-Network Hydrogels with Quantitative Mechanochemical Characterization of the Damage Zone
    T. Matsuda, R. Kawakami, T. Nakajima, Y. Hane, J. P. Gong, Macromolecules, 2021, 54, 10331-10339
    DOI: 10.1021/acs.macromol.1c01214
  • Tiny yet Tough: Maximizing the Toughness of Fiber-Reinforced Soft Composites in the Absence of a Fiber-Fracture Mechanism
    W. Cui, Y. W. Huang, L. Chen, Y. Zheng, Y. Saruwatari, C. Y. Hui, T. Kurokawa, D. R. King, J. P. Gong, Matter, 2021, 4, 3646-3661
    DOI: 10.1016/j.matt.2021.08.013
  • Structure Frustration Enables Thermal History-Dependent Responsive Behavior in Self-Healing Hydrogels
    C. T. Yu, K. P. Cui, H. L. Guo, Y. N. Ye, X. Y. Li, J. P. Gong, Macromolecules, 2021, 54, 9927-9936
    DOI: 10.1021/acs.macromol.1c01461
  • Hydroxyapatite-Hybridized Double-Network Hydrogel Surface Enhances Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells to Osteogenic Cells
    T. Kaibara, L. Wang, M. Tsuda, T. Nonoyama, T. Kurokawa, N. Iwasaki, J. P. Gong, S. Tanaka, K. Yasuda, Journal of Biomedical Materials Research Part A, 2021, 110, 747-760
    DOI: 10.1002/jbm.a.37324
  • Toughening Hydrogels through Force-Triggered Chemical Reactions that Lengthen Polymer Strands
    Z. Wang, X. J. Zheng, T. Ouchi, T. B. Kouznetsova, H. K. Beech, S. Av-Ron, T. Matsuda, B. H. Bowser, S. Wang, J. A. Johnson, J. A. Kalow, B. D. Olsen, J. P. Gong, M. Rubinstein, S. L. Craig, Science, 2021, 374, 193-+
    DOI: 10.1126/science.abg2689
  • Bioinspired Underwater Adhesives
    H. L. Fan, J. P. Gong, Adv. Mater., 2021, 33,
    DOI: 10.1002/adma.202102983
  • Structure and Unique Functions of Anisotropic Hydrogels Comprising Uniaxially Aligned Lamellar Bilayers
    Y. F. Yue, J. P. Gong, Bulletin of the Chemical Society of Japan, 2021, 94, 2221-2234
    DOI: 10.1246/bcsj.20210209
  • Fast in Vivo Fixation of Double Network Hydrogel to Bone by Monetite Surface Hybridization
    T. Nonoyama, L. Wang, R. Kiyama, N. Kashimura, K. Yasuda, S. Tanaka, T. Kurokawa, J. P. Gong, Journal of the Ceramic Society of Japan, 2021, 129, 584-589
    DOI: 10.2109/jcersj2.21084
  • Facile Tuning of Hydrogel Properties by Manipulating Cationic-Aromatic Monomer Sequences
    H. L. Fan, Y. R. Cai, J. P. Gong, Science China-Chemistry, 2021, 64, 1560-1568
    DOI: 10.1007/s11426-021-1010-3
  • Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model
    L. Xu, A. Urita, T. Onodera, R. Hishimura, T. Nonoyama, M. Hamasaki, D. W. Liang, K. Homan, J. P. Gong, N. Iwasaki, American Journal of Sports Medicine, 2021, 49, 2199-2210
    DOI: 10.1177/03635465211014186
  • A Surface Flattening Method for Characterizing the Surface Stress, Drained Poisson's Ratio and Diffusivity of Poroelastic Gels
    Z. Z. Liu, C. Y. Hui, A. Jagota, J. P. Gong, R. Kiyama, Soft Matter, 2021, 17, 7332-7340
    DOI: 10.1039/d1sm00513h
  • Experimental Verification of the Balance between Elastic Pressure and Ionic Osmotic Pressure of Highly Swollen Charged Gels
    T. Nakajima, K. Hoshino, H. L. Guo, T. Kurokawa, J. P. Gong, Gels, 2021, 7,
    DOI: 10.3390/gels7020039
  • Improving the Strength and Toughness of Macroscale Double Networks by Exploiting Poisson's Ratio Mismatch
    T. Okumura, R. Takahashi, K. Hagita, D. R. King, J. P. Gong, Scientific Reports, 2021, 11,
    DOI: 10.1038/s41598-021-92773-0
  • Tough Double Network Hydrogel and Its Biomedical Applications
    T. Nonoyama, J. P. Gong, Annual Review of Chemical and Biomolecular Engineering, Vol 12, 2021, 2021, 12, 393-410
    DOI: 10.1146/annurev-chembioeng-101220-080338
  • Flower-like Photonic Hydrogel with Superstructure Induced via Modulated Shear Field
    Y. N. Ye, M. A. Haque, A. Inoue, Y. Katsuyama, T. Kurokawa, J. P. Gong, ACS Macro Lett., 2021, 10, 708-713
    DOI: 10.1021/acsmacrolett.1c00178
  • Hierarchical Toughening: A Step Toward Matching the Complexity of Biological Materials
    D. R. King, J. P. Gong, Chem, 2021, 7, 1153-1155
    DOI: 10.1016/j.chempr.2021.04.013
  • Quantitative Evaluation of Macromolecular Crowding Environment Based on Translational and Rotational Diffusion Using Polarization Dependent Fluorescence Correlation Spectroscopy
    J. Yamamoto, A. Matsui, F. Gan, M. Oura, R. Ando, T. Matsuda, J. P. Gong, M. Kinjo, Scientific Reports, 2021, 11,
    DOI: 10.1038/s41598-021-89987-7
  • Nanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance
    Y. Zheng, R. Kiyama, T. Matsuda, K. P. Cui, X. Y. Li, W. Cui, Y. Z. Guo, T. Nakajima, T. Kurokawa, J. P. Gong, Chem. Mater., 2021, 33, 3321-3334
    DOI: 10.1021/acs.chemmater.1c00512
  • Ultrahigh-Water-Content Photonic Hydrogels with Large Electro-Optic Responses in Visible to Near-Infrared Region
    Y. F. Yue, Y. Norikane, J. P. Gong, Advanced Optical Materials, 2021, 9, 9
    DOI: 10.1002/adom.202002198
  • Aggregated Structures and Their Functionalities in Hydrogels
    K. P. Cui, J. P. Gong, Aggregate, 2021, 2,
    DOI: 10.1002/agt2.33
  • Effect of Mesoscale Phase Contrast on Fatigue-Delaying Behavior of Self-Healing Hydrogels
    X. Y. Li, K. P. Cui, T. Kurokawa, Y. N. Ye, T. L. Sun, C. T. Yu, C. T. Creton, J. P. Gong, Science Advances, 2021, 7, 9
    DOI: 10.1126/sciadv.abe8210
  • Constitutive Modeling of Strain-Dependent Bond Breaking and Healing Kinetics of Chemical Polyampholyte (PA) Gel Dagger
    S. P. Venkata, K. P. Cui, J. Y. Guo, A. T. Zehnder, J. P. Gong, C. Y. Hui, Soft Matter, 2021, 17, 4161-4169
    DOI: 10.1039/d1sm00110h
  • Molecular Mechanism of Abnormally Large Nonsoftening Deformation in a Tough Hydrogel
    Y. N. Ye, K. P. Cui, W. Hong, X. Y. Li, C. T. Yu, D. Hourdet, T. Nakajima, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, 5
    DOI: 10.1073/pnas.2014694118
  • Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    J. Suzuka, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
    DOI: 10.1038/s41551-021-00692-2
  • The Fracture of Highly Deformable Soft Materials: A Tale of Two Length Scales
    R. Long, C. Y. Hui, J. P. Gong, E. Bouchbinder, Annual Review of Condensed Matter Physics, Vol 12, 2021, 2021, 12, 71-94
    DOI: 10.1146/annurev-conmatphys-042020-023937
  • Constitutive Modeling of Bond Breaking and Healing Kinetics of Physical Polyampholyte (PA) Gel
    S. P. Venkata, K. P. Cui, J. Y. Guo, A. T. Zehnder, J. P. Gong, C. Y. Hui, Extreme Mechanics Letters, 2021, 43, 13
    DOI: 10.1016/j.eml.2021.101184
  • Micromechanical Modeling of the Multi-Axial Deformation Behavior in Double Network Hydrogels
    R. Xiao, T. T. Mai, K. Urayama, J. P. Gong, S. X. Qu, International Journal of Plasticity, 2021, 137, 19
    DOI: 10.1016/j.ijplas.2020.102901

2020年

  • Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins
    T. Nonoyama, YW. Lee, K. Ota, K. Fujioka, W. Hong, JP. Gong, Adv. Mater., 2020, 32, 1905878
    DOI: 10.1002/adma.201905878
  • Barnacle Cement Proteins-Inspired Tough Hydrogels with Robust, Long-Lasting, and Repeatable Underwater Adhesion
    H. L. Fan, J. H. Wang, J. P. Gong, Advanced Functional Materials, 2020, ,
    DOI: 10.1002/adfm.202009334
  • Bactericidal Effect of Cationic Hydrogels Prepared from Hydrophilic Polymers
    Y. Shibata, T. Kurokawa, T. Aizawa, J. P. Gong, Journal of Applied Polymer Science, 2020, 137, 10
    DOI: 10.1002/app.49583
  • Stress Relaxation and Underlying Structure Evolution in Tough and Self-Healing Hydrogels
    K. P. Cui, Y. N. Ye, C. T. Yu, X. Y. Li, T. Kurokawa, J. P. Gong, ACS Macro Lett., 2020, 9, 1582-1589
    DOI: 10.1021/acsmacrolett.0c00600
  • Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone
    T. Nonoyama, L. Wang, M. Tsuda, Y. Suzuki, R. Kiyama, K. Yasuda, S. Tanaka, K. Nagata, R. Fujita, N. Sakamoto, N. Kawasaki, H. Yurimoto, J. P. Gong, Advanced Healthcare Materials, 2020, ,
    DOI: 10.1002/adhm.202001731
  • How Surface Stress Transforms Surface Profiles and Adhesion of Rough Elastic Bodies
    C. Y. Hui, Z. Z. Liu, N. Bain, A. Jagota, E. R. Dufresne, R. W. Style, R. Kiyama, J. P. Gong, Proceedings of the Royal Society a-Mathematical Physical and Engineering Sciences, 2020, 476,
    DOI: 10.1098/rspa.2020.0477
  • Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
    J. C. Huang, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
    DOI: 10.1021/acs.biomac.0c01033
  • Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization
    T. Matsuda, R. Kawakami, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 8787-8795
    DOI: 10.1021/acs.macromol.0c01485
  • Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
    T. Sedlacik, T. Nonoyama, H. L. Guo, R. Kiyama, T. Nakajima, Y. Takeda, T. Kurokawa, J. P. Gong, Chem. Mater., 2020, 32, 8576-8586
    DOI: 10.1021/acs.chemmater.0c02911
  • Effect of the Constituent Networks of Double-Network Gels on Their Mechanical Properties and Energy Dissipation Process
    T. Nakajima, T. Kurokawa, H. Furukawa, J. P. Gong, Soft Matter, 2020, 16, 8618-8627
    DOI: 10.1039/d0sm01057j
  • High-Fidelity Hydrogel Thin Films Processed from Deep Eutectic Solvents
    D. E. Delgado, D. R. King, K. P. Cui, J. P. Gong, K. R. Shull, ACS Appl. Mater. Interfaces, 2020, 12, 43191-43200
    DOI: 10.1021/acsami.0c09618
  • Fiber-Reinforced Viscoelastomers Show Extraordinary Crack Resistance That Exceeds Metals
    W. Cui, D. R. King, Y. W. Huang, L. Chen, T. L. Sun, Y. Z. Guo, Y. Saruwatari, C. Y. Hui, T. Kurokawa, J. P. Gong, Adv. Mater., 2020, 32, 9
    DOI: 10.1002/adma.201907180
  • Hydrogels as Dynamic Memory with Forgetting Ability
    C. T. Yu, H. L. Guo, K. P. Cui, X. Y. Li, Y. N. Ye, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117, 18962-18968
    DOI: 10.1073/pnas.2006842117
  • Phase Separation Behavior in Tough and Self-Healing Polyampholyte Hydrogels
    K. P. Cui, Y. N. Ye, T. L. Sun, C. T. Yu, X. Y. Li, T. Kurokawa, J. P. Gong, Macromolecules, 2020, 53, 5116-5126
    DOI: 10.1021/acs.macromol.0c00577
  • Hydrogels Toughened by Biominerals Providing Energy-Dissipative Sacrificial Bonds
    K. Fukao, K. Tanaka, R. Kiyama, T. Nonoyama, J. P. Gong, J. Mater. Chem. B, 2020, 8, 5184-5188
    DOI: 10.1039/d0tb00833h
  • Integrin Alpha 4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiation
    D. Hashimoto, S. Semba, M. Tsuda, T. Kurokawa, N. Kitamura, K. Yasuda, J. P. Gong, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 528, 120-126
    DOI: 10.1016/j.bbrc.2020.05.071
  • Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
    S. Hirayama, T. Kurokawa, J. P. Gong, Tribology International, 2020, 147, 7
    DOI: 10.1016/j.triboint.2020.106270
  • Lamellar Bilayer to Fibril Structure Transformation of Tough Photonic Hydrogel under Elongation
    M. A. Haque, K. P. Cui, M. Ilyas, T. Kurokawa, A. Marcellan, A. Brulet, R. Takahashi, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 4711-4721
    DOI: 10.1021/acs.macromol.0c00878
  • Anisotropic Double-Network Hydrogels via Controlled Orientation of a Physical Sacrificial Network
    D. R. King, R. Takahashi, T. Ikai, K. Fukao, T. Kurokawa, J. P. Gong, Acs Applied Polymer Materials, 2020, 2, 2350-2358
    DOI: 10.1021/acsapm.0c00290
  • Double-Network Gels as Polyelectrolyte Gels with Salt-Insensitive Swelling Properties
    T. Nakajima, T. Chida, K. Mito, T. Kurokawa, J. P. Gong, Soft Matter, 2020, 16, 5487-5496
    DOI: 10.1039/d0sm00605j
  • Synthetic Poly(2-Acrylamido-2-Methylpropanesulfonic Acid) Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
    S. Semba, N. Kitamura, M. Tsuda, K. Goto, S. Kurono, Y. Ohmiya, T. Kurokawa, J. P. Gong, K. Yasuda, S. Tanaka, Journal of Biomedical Materials Research Part A, 2020, ,
    DOI: 10.1002/jbm.a.37028
  • Fabrication of Bioinspired Hydrogels: Challenges and Opportunities
    H. L. Fan, J. P. Gong, Macromolecules, 2020, 53, 2769-2782
    DOI: 10.1021/acs.macromol.0c00238
  • Mesoscale Bicontinuous Networks in Self-Healing Hydrogels Delay Fatigue Fracture
    X. Y. Li, K. P. Cui, T. L. Sun, L. P. Meng, C. T. Yu, L. B. Li, C. Creton, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117, 7606-7612
    DOI: 10.1073/pnas.2000189117
  • Effect of Relative Strength of Two Networks on the Internal Fracture Process of Double Network Hydrogels As Revealed by in Situ Small-Angle X-Ray Scattering
    K. Fukao, T. Nakajima, T. Nonoyama, T. Kurokawa, T. Kawai, J. P. Gong, Macromolecules, 2020, 53, 1154-1163
    DOI: 10.1021/acs.macromol.9b02562
  • Mechanical Behavior of Unidirectional Fiber Reinforced Soft Composites
    C. Y. Hui, Z. Z. Liu, S. L. Phoenix, D. R. King, W. Cui, Y. W. Huang, J. P. Gong, Extreme Mechanics Letters, 2020, 35, 13
    DOI: 10.1016/j.eml.2020.100642

2019年

  • Adjacent Cationic–aromatic Sequences Yield Strong Electrostatic Adhesion of Hydrogels in Seawater
    HL. Fan, JH. Wang, Z. Tao, JC. Huang, P. Rao, T. Kurokawa, JP. Gong, Nat. Commun., 2019, 10, 5127
    DOI: 10.1038/s41467-019-13171-9
  • Facile Synthesis of Novel Elastomers with Tunable Dynamics for Toughness, Self-Healing and Adhesion
    L. Chen, TL. Sun, KP. Cui, DR. King, T. Kurokawa, Y. Saruwatari, JP. Gong, J. Mater. Chem. A, 2019, 7, 17334-17344
    DOI: 10.1039/c9ta04840e
  • Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
    M. Frauenlob, DR. King, HL. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, JP. Gong, Macromolecules, 2019, 52, 6704-6713
    DOI: 10.1021/acs.macromol.9b01399
  • Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
    HL. Guo, W. Hong, T. Kurokawa, T. Matsuda, ZL. Wu, T. Nakajima, M. Takahata, TL. Sun, P. Rao, JP. Gong, Macromolecules, 2019, 52, 7114-7122
    DOI: 10.1021/acs.macromol.9b01308
  • Hydrophobic Hydrogels with Fruit-Like Structure and Functions
    H. Guo, T. Nakajima, D. Hourdet, A. Marcellan, C. Creton, W. Hong, T. Kurokawa, JP. Gong, Adv. Mater., 2019, 31, 1900702
    DOI: 10.1002/adma.201900702
  • Superior Fracture Resistance of Fiber Reinforced Polyampholyte Hydrogels Achieved by Extraordinarily Large Energy-Dissipative Process Zones
    YW. Huang, DR. King, W. Cui, TL. Sun, HL. Guo, T. Kurokawa, HR. Brown, CY. Hui, JP. Gong, J. Mater. Chem. A, 2019, 7, 13431-13440
    DOI: 10.1039/c9ta02326g
  • Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
    DR. King, T. Okumura, R. Takahashi, T. Kurokawa, JP. Gong, ACS Appl. Mater. Interfaces, 2019, 11, 35343-35353
    DOI: 10.1021/acsami.9b12935
  • Damage Cross-Effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
    TT. Mai, T. Matsuda, T. Nakajima, JP. Gong, K. Urayama, Soft Matter, 2019, 15, 3719-3732
    DOI: 10.1039/c9sm00409b
  • Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
    T. Matsuda, T. Nakajima, JP. Gong, Chem. Mater., 2019, 31, 3766-3776
    DOI: 10.1021/acs.chemmater.9b00871
  • Polyelectrolyte Complexation via Viscoelastic Phase Separation Results in Tough and Self-Recovering Porous Hydrogels
    K. Murakawa, DR. King, TL. Sun, HL. Guo, T. Kurokawa, JP. Gong, J. Mater. Chem. B, 2019, 7, 5296-5305
    DOI: 10.1039/c9tb01376h
  • Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
    J. Murat, T. Nakajima, T. Matsuda, K. Tsunoda, T. Nonoyama, T. Kurokawa, JP. Gong, Polymer, 2019, 178, 121686
    DOI: 10.1016/j.polymer.2019.121686
  • Tough Double-Network Gels and Elastomers from the Nonprestretched First Network
    T. Nakajima, Y. Ozaki, R. Namba, K. Ota, Y. Maida, T. Matsuda, T. Kurokawa, JP. Gong, ACS Macro Lett., 2019, 8, 1407-1412
    DOI: 10.1021/acsmacrolett.9b00679
  • Programmed Diffusion Induces Anisotropic Superstructures in Hydrogels with High Mechano-Optical Sensitivity
    LC. Qiao, C. Du, JP. Gong, ZL. Wu, Q. Zheng, Adv. Mater. Technol., 2019, 4, 1900665
    DOI: 10.1002/admt.201900665
  • Double Network Hydrogels Based on Semi-Rigid Polyelectrolyte Physical Networks
    R. Takahashi, T. Ikai, T. Kurokawa, DR. King, JP. Gong, J. Mater. Chem. B, 2019, 7, 6347-6354
    DOI: 10.1039/c9tb01217f
  • Fabrication of Tough Hydrogel Composites from Photoresponsive Polymers to Show Double-Network Effect
    Z. Tao, HL. Fan, JC. Huang, TL. Sun, T. Kurokawa, JP. Gong, ACS Appl. Mater. Interfaces, 2019, 11, 37139-37146
    DOI: 10.1021/acsami.9b13746
  • Shearing-Induced Contact Pattern Formation in Hydrogels Sliding in Polymer Solution
    S. Yashima, S. Hirayama, T. Kurokawa, T. Salez, H. Takefuji, W. Hong, JP. Gong, Soft Matter, 2019, 15, 1953-1959
    DOI: 10.1039/c8sm02428f
  • Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
    YN. Ye, KP. Cui, T. Indei, T. Nakajima, D. Hourdet, T. Kurokawa, JP. Gong, Macromolecules, 2019, 52, 8651-8661
    DOI: 10.1021/acs.macromol.9b01856

2018年

  • Network Elasticity of a Model Hydrogel as a Function of Swelling Ratio: From Shrinking to Extreme Swelling States
    K. Hoshino, T. Nakajima, T. Matsuda, T. Sakai, JP. Gong, Soft Matter, 2018, 14, 9693-9701
    DOI: 10.1039/c8sm01854e