GONG, Jian Ping

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GONG, Jian Ping
Principal Investigator
Hokkaido University
Research Areas
Polymer science, Soft matter, Gel science
Related Website
Contact

gong atmark sci.hokudai.ac.jp

GONG, Jian Ping Group
Principal Investigator
  • thumbnail image
    GONG, Jian Ping
Faculty Members
Research Collaborators
Staff
  • HANE, Yukiko

About the Research

Research Theme

Synthesis of high performance hydrogels and soft matter. Especially focused on tough gels, self-evolving gels, low friction gels, adhesive gels, biocompatible gels.

Keyword

Polymer gel, Biomaterials, Regenerative medicine

Research Outline

The ultimate goal of our research is the development of strong and highly functional gels that outperform soft tissues of the body, such as muscle, cartilage, and tendons. In addition, we try to find applications for these materials in a variety of scientific fields, including in the medical field. Together with ICReDD, we want to design these materials on a molecular level to create metabolizing, self-growing, and thus adaptive tissues.

Drawing inspiration from biological systems, we make assumptions on the reason behind their function and try to create artificial structures with comparable or superior characteristics. We then verify the assumptions experimentally and explore the artificial system’s physical properties. The results of this inform the next round of assumptions and artificial systems.

The Researcher’s Perspective

Being a scientist is a unique job. It requires creativity and devotion, much like an artist, and allows following one’s interest freely. Discovering or inventing something in this process is very rewarding. I was inspired to become a scientist by reading, as a child, biographies of researchers, especially of Marie Curie. As a girl, I was encouraged by the fact that she could achieve so highly in times that difficult for women. But even today, I hope the number of female Ph.D. students and scientists in chemistry will increase more and more.

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Representative Research Achievements

  • Double Network Hydrogels with Extremely High Mechanical Strength
    J. P. Gong, Y. Katsuyama, T. Kurokawa, Y. Osada, Adv. Mat., 2003, 15, 1155-1158
    DOI : 10.1002/adma.200304907
  • Why Are Double Network Hydrogels So Tough?
    J. P. Gong, Soft Mater., 2010, 6, 2583-2590
    DOI : 10.1039/B924290B
  • Physical Hydrogels Composed of Polyampholytes Demonstrate High Toughness and Viscoelasticity
    T. L. Sun, T. Kurokawa, S. Kuroda, A. B. Ihsan, T. Akasaki, K. Sato, Md. A. Haque, T. Nakajima, J. P. Gong, Nat. Mater., 2013, 12, 932-937
    DOI : 10.1038/nmat3713
  • Large Strain Hysteresis and Mullins Effect of Tough Double-Network Hydrogels
    R. E. Webber, C. Creton, H. R. Brown, J. P. Gong, Macromolecules, 2007, 40, 2919-2917
    DOI : 10.1021/ma062924y
  • Super Tough Double Network Hydrogels and Their Application as Biomaterials
    Md. A. Haque, T. Kurokawa, J. P. Gong, Polymer, 2012, 53, 1805-1822
    DOI : 10.1016/j.polymer.2012.03.013
  • Tough Hydrogels with Fast, Strong, and Reversible Underwater Adhesion Based on a Multi-Scale Design
    Ping Rao, Tao Lin Sun, Liang Chen, Riku Takahashi, Gento Shinohara, Hui Guo, Daniel R. King, Takayuki Kurokawa, Jian Ping Gong, Advanced Materials, 2018, 30(32), 1801884
    DOI : 10.1002/adma.201801884
  • Mechanoresponsive self-growing hydrogels inspired by muscle training
    Takahiro Matsuda et al., Science, 2019, 363(6426), 504-508
    DOI : 10.1126/science.aau9533

Related Research

Publications

2021

  • Facile Tuning of Hydrogel Properties by Manipulating Cationic-Aromatic Monomer Sequences
    H. L. Fan, Y. R. Cai, J. P. Gong, Science China-Chemistry, 2021, ,
    DOI: 10.1007/s11426-021-1010-3
  • Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model
    L. Xu, A. Urita, T. Onodera, R. Hishimura, T. Nonoyama, M. Hamasaki, D. W. Liang, K. Homan, J. P. Gong, N. Iwasaki, American Journal of Sports Medicine, 2021, 49, 2199-2210
    DOI: 10.1177/03635465211014186
  • A Surface Flattening Method for Characterizing the Surface Stress, Drained Poisson's Ratio and Diffusivity of Poroelastic Gels
    Z. Z. Liu, C. Y. Hui, A. Jagota, J. P. Gong, R. Kiyama, Soft Matter, 2021, ,
    DOI: 10.1039/d1sm00513h
  • Experimental Verification of the Balance between Elastic Pressure and Ionic Osmotic Pressure of Highly Swollen Charged Gels
    T. Nakajima, K. Hoshino, H. L. Guo, T. Kurokawa, J. P. Gong, Gels, 2021, 7,
    DOI: 10.3390/gels7020039
  • Improving the Strength and Toughness of Macroscale Double Networks by Exploiting Poisson's Ratio Mismatch
    T. Okumura, R. Takahashi, K. Hagita, D. R. King, J. P. Gong, Scientific Reports, 2021, 11,
    DOI: 10.1038/s41598-021-92773-0
  • Tough Double Network Hydrogel and Its Biomedical Applications
    T. Nonoyama, J. P. Gong, Annual Review of Chemical and Biomolecular Engineering, Vol 12, 2021, 2021, 12, 393-410
    DOI: 10.1146/annurev-chembioeng-101220-080338
  • Flower-like Photonic Hydrogel with Superstructure Induced via Modulated Shear Field
    Y. N. Ye, M. A. Haque, A. Inoue, Y. Katsuyama, T. Kurokawa, J. P. Gong, ACS Macro Lett., 2021, 10, 708-713
    DOI: 10.1021/acsmacrolett.1c00178
  • Hierarchical Toughening: A Step Toward Matching the Complexity of Biological Materials
    D. R. King, J. P. Gong, Chem, 2021, 7, 1153-1155
    DOI: 10.1016/j.chempr.2021.04.013
  • Quantitative Evaluation of Macromolecular Crowding Environment Based on Translational and Rotational Diffusion Using Polarization Dependent Fluorescence Correlation Spectroscopy
    J. Yamamoto, A. Matsui, F. Gan, M. Oura, R. Ando, T. Matsuda, J. P. Gong, M. Kinjo, Scientific Reports, 2021, 11,
    DOI: 10.1038/s41598-021-89987-7
  • Nanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance
    Y. Zheng, R. Kiyama, T. Matsuda, K. P. Cui, X. Y. Li, W. Cui, Y. Z. Guo, T. Nakajima, T. Kurokawa, J. P. Gong, Chem. Mater., 2021, 33, 3321-3334
    DOI: 10.1021/acs.chemmater.1c00512
  • Ultrahigh-Water-Content Photonic Hydrogels with Large Electro-Optic Responses in Visible to Near-Infrared Region
    Y. F. Yue, Y. Norikane, J. P. Gong, Advanced Optical Materials, 2021, 9, 9
    DOI: 10.1002/adom.202002198
  • Effect of Mesoscale Phase Contrast on Fatigue-Delaying Behavior of Self-Healing Hydrogels
    X. Y. Li, K. P. Cui, T. Kurokawa, Y. N. Ye, T. L. Sun, C. T. Yu, C. T. Creton, J. P. Gong, Science Advances, 2021, 7, 9
    DOI: 10.1126/sciadv.abe8210
  • Constitutive Modeling of Strain-Dependent Bond Breaking and Healing Kinetics of Chemical Polyampholyte (PA) Gel Dagger
    S. P. Venkata, K. P. Cui, J. Y. Guo, A. T. Zehnder, J. P. Gong, C. Y. Hui, Soft Matter, 2021, 17, 4161-4169
    DOI: 10.1039/d1sm00110h
  • Molecular Mechanism of Abnormally Large Nonsoftening Deformation in a Tough Hydrogel
    Y. N. Ye, K. P. Cui, W. Hong, X. Y. Li, C. T. Yu, D. Hourdet, T. Nakajima, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2021, 118, 5
    DOI: 10.1073/pnas.2014694118
  • Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    J. Suzuka, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
    DOI: 10.1038/s41551-021-00692-2
  • The Fracture of Highly Deformable Soft Materials: A Tale of Two Length Scales
    R. Long, C. Y. Hui, J. P. Gong, E. Bouchbinder, Annual Review of Condensed Matter Physics, Vol 12, 2021, 2021, 12, 71-94
    DOI: 10.1146/annurev-conmatphys-042020-023937
  • Constitutive Modeling of Bond Breaking and Healing Kinetics of Physical Polyampholyte (PA) Gel
    S. P. Venkata, K. P. Cui, J. Y. Guo, A. T. Zehnder, J. P. Gong, C. Y. Hui, Extreme Mechanics Letters, 2021, 43, 13
    DOI: 10.1016/j.eml.2021.101184
  • Micromechanical Modeling of the Multi-Axial Deformation Behavior in Double Network Hydrogels
    R. Xiao, T. T. Mai, K. Urayama, J. P. Gong, S. X. Qu, International Journal of Plasticity, 2021, 137, 19
    DOI: 10.1016/j.ijplas.2020.102901

2020

  • Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins
    T. Nonoyama, YW. Lee, K. Ota, K. Fujioka, W. Hong, JP. Gong, Adv. Mater., 2020, 32, 1905878
    DOI: 10.1002/adma.201905878
  • Barnacle Cement Proteins-Inspired Tough Hydrogels with Robust, Long-Lasting, and Repeatable Underwater Adhesion
    H. L. Fan, J. H. Wang, J. P. Gong, Advanced Functional Materials, 2020, ,
    DOI: 10.1002/adfm.202009334
  • Bactericidal Effect of Cationic Hydrogels Prepared from Hydrophilic Polymers
    Y. Shibata, T. Kurokawa, T. Aizawa, J. P. Gong, Journal of Applied Polymer Science, 2020, 137, 10
    DOI: 10.1002/app.49583
  • Stress Relaxation and Underlying Structure Evolution in Tough and Self-Healing Hydrogels
    K. P. Cui, Y. N. Ye, C. T. Yu, X. Y. Li, T. Kurokawa, J. P. Gong, ACS Macro Lett., 2020, 9, 1582-1589
    DOI: 10.1021/acsmacrolett.0c00600
  • Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone
    T. Nonoyama, L. Wang, M. Tsuda, Y. Suzuki, R. Kiyama, K. Yasuda, S. Tanaka, K. Nagata, R. Fujita, N. Sakamoto, N. Kawasaki, H. Yurimoto, J. P. Gong, Advanced Healthcare Materials, 2020, ,
    DOI: 10.1002/adhm.202001731
  • How Surface Stress Transforms Surface Profiles and Adhesion of Rough Elastic Bodies
    C. Y. Hui, Z. Z. Liu, N. Bain, A. Jagota, E. R. Dufresne, R. W. Style, R. Kiyama, J. P. Gong, Proceedings of the Royal Society a-Mathematical Physical and Engineering Sciences, 2020, 476,
    DOI: 10.1098/rspa.2020.0477
  • Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
    J. C. Huang, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
    DOI: 10.1021/acs.biomac.0c01033
  • Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization
    T. Matsuda, R. Kawakami, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 8787-8795
    DOI: 10.1021/acs.macromol.0c01485
  • Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
    T. Sedlacik, T. Nonoyama, H. L. Guo, R. Kiyama, T. Nakajima, Y. Takeda, T. Kurokawa, J. P. Gong, Chem. Mater., 2020, 32, 8576-8586
    DOI: 10.1021/acs.chemmater.0c02911
  • Effect of the Constituent Networks of Double-Network Gels on Their Mechanical Properties and Energy Dissipation Process
    T. Nakajima, T. Kurokawa, H. Furukawa, J. P. Gong, Soft Matter, 2020, 16, 8618-8627
    DOI: 10.1039/d0sm01057j
  • High-Fidelity Hydrogel Thin Films Processed from Deep Eutectic Solvents
    D. E. Delgado, D. R. King, K. P. Cui, J. P. Gong, K. R. Shull, ACS Appl. Mater. Interfaces, 2020, 12, 43191-43200
    DOI: 10.1021/acsami.0c09618
  • Fiber-Reinforced Viscoelastomers Show Extraordinary Crack Resistance That Exceeds Metals
    W. Cui, D. R. King, Y. W. Huang, L. Chen, T. L. Sun, Y. Z. Guo, Y. Saruwatari, C. Y. Hui, T. Kurokawa, J. P. Gong, Adv. Mater., 2020, 32, 9
    DOI: 10.1002/adma.201907180
  • Hydrogels as Dynamic Memory with Forgetting Ability
    C. T. Yu, H. L. Guo, K. P. Cui, X. Y. Li, Y. N. Ye, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117, 18962-18968
    DOI: 10.1073/pnas.2006842117
  • Phase Separation Behavior in Tough and Self-Healing Polyampholyte Hydrogels
    K. P. Cui, Y. N. Ye, T. L. Sun, C. T. Yu, X. Y. Li, T. Kurokawa, J. P. Gong, Macromolecules, 2020, 53, 5116-5126
    DOI: 10.1021/acs.macromol.0c00577
  • Hydrogels Toughened by Biominerals Providing Energy-Dissipative Sacrificial Bonds
    K. Fukao, K. Tanaka, R. Kiyama, T. Nonoyama, J. P. Gong, J. Mater. Chem. B, 2020, 8, 5184-5188
    DOI: 10.1039/d0tb00833h
  • Integrin Alpha 4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiation
    D. Hashimoto, S. Semba, M. Tsuda, T. Kurokawa, N. Kitamura, K. Yasuda, J. P. Gong, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 528, 120-126
    DOI: 10.1016/j.bbrc.2020.05.071
  • Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
    S. Hirayama, T. Kurokawa, J. P. Gong, Tribology International, 2020, 147, 7
    DOI: 10.1016/j.triboint.2020.106270
  • Lamellar Bilayer to Fibril Structure Transformation of Tough Photonic Hydrogel under Elongation
    M. A. Haque, K. P. Cui, M. Ilyas, T. Kurokawa, A. Marcellan, A. Brulet, R. Takahashi, T. Nakajima, J. P. Gong, Macromolecules, 2020, 53, 4711-4721
    DOI: 10.1021/acs.macromol.0c00878
  • Anisotropic Double-Network Hydrogels via Controlled Orientation of a Physical Sacrificial Network
    D. R. King, R. Takahashi, T. Ikai, K. Fukao, T. Kurokawa, J. P. Gong, Acs Applied Polymer Materials, 2020, 2, 2350-2358
    DOI: 10.1021/acsapm.0c00290
  • Double-Network Gels as Polyelectrolyte Gels with Salt-Insensitive Swelling Properties
    T. Nakajima, T. Chida, K. Mito, T. Kurokawa, J. P. Gong, Soft Matter, 2020, 16, 5487-5496
    DOI: 10.1039/d0sm00605j
  • Synthetic Poly(2-Acrylamido-2-Methylpropanesulfonic Acid) Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
    S. Semba, N. Kitamura, M. Tsuda, K. Goto, S. Kurono, Y. Ohmiya, T. Kurokawa, J. P. Gong, K. Yasuda, S. Tanaka, Journal of Biomedical Materials Research Part A, 2020, ,
    DOI: 10.1002/jbm.a.37028
  • Fabrication of Bioinspired Hydrogels: Challenges and Opportunities
    H. L. Fan, J. P. Gong, Macromolecules, 2020, 53, 2769-2782
    DOI: 10.1021/acs.macromol.0c00238
  • Mesoscale Bicontinuous Networks in Self-Healing Hydrogels Delay Fatigue Fracture
    X. Y. Li, K. P. Cui, T. L. Sun, L. P. Meng, C. T. Yu, L. B. Li, C. Creton, T. Kurokawa, J. P. Gong, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117, 7606-7612
    DOI: 10.1073/pnas.2000189117
  • Effect of Relative Strength of Two Networks on the Internal Fracture Process of Double Network Hydrogels As Revealed by in Situ Small-Angle X-Ray Scattering
    K. Fukao, T. Nakajima, T. Nonoyama, T. Kurokawa, T. Kawai, J. P. Gong, Macromolecules, 2020, 53, 1154-1163
    DOI: 10.1021/acs.macromol.9b02562
  • Mechanical Behavior of Unidirectional Fiber Reinforced Soft Composites
    C. Y. Hui, Z. Z. Liu, S. L. Phoenix, D. R. King, W. Cui, Y. W. Huang, J. P. Gong, Extreme Mechanics Letters, 2020, 35, 13
    DOI: 10.1016/j.eml.2020.100642

2019

  • Adjacent Cationic–aromatic Sequences Yield Strong Electrostatic Adhesion of Hydrogels in Seawater
    HL. Fan, JH. Wang, Z. Tao, JC. Huang, P. Rao, T. Kurokawa, JP. Gong, Nat. Commun., 2019, 10, 5127
    DOI: 10.1038/s41467-019-13171-9
  • Facile Synthesis of Novel Elastomers with Tunable Dynamics for Toughness, Self-Healing and Adhesion
    L. Chen, TL. Sun, KP. Cui, DR. King, T. Kurokawa, Y. Saruwatari, JP. Gong, J. Mater. Chem. A, 2019, 7, 17334-17344
    DOI: 10.1039/c9ta04840e
  • Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
    M. Frauenlob, DR. King, HL. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, JP. Gong, Macromolecules, 2019, 52, 6704-6713
    DOI: 10.1021/acs.macromol.9b01399
  • Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
    HL. Guo, W. Hong, T. Kurokawa, T. Matsuda, ZL. Wu, T. Nakajima, M. Takahata, TL. Sun, P. Rao, JP. Gong, Macromolecules, 2019, 52, 7114-7122
    DOI: 10.1021/acs.macromol.9b01308
  • Hydrophobic Hydrogels with Fruit-Like Structure and Functions
    H. Guo, T. Nakajima, D. Hourdet, A. Marcellan, C. Creton, W. Hong, T. Kurokawa, JP. Gong, Adv. Mater., 2019, 31, 1900702
    DOI: 10.1002/adma.201900702
  • Superior Fracture Resistance of Fiber Reinforced Polyampholyte Hydrogels Achieved by Extraordinarily Large Energy-Dissipative Process Zones
    YW. Huang, DR. King, W. Cui, TL. Sun, HL. Guo, T. Kurokawa, HR. Brown, CY. Hui, JP. Gong, J. Mater. Chem. A, 2019, 7, 13431-13440
    DOI: 10.1039/c9ta02326g
  • Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
    DR. King, T. Okumura, R. Takahashi, T. Kurokawa, JP. Gong, ACS Appl. Mater. Interfaces, 2019, 11, 35343-35353
    DOI: 10.1021/acsami.9b12935
  • Damage Cross-Effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
    TT. Mai, T. Matsuda, T. Nakajima, JP. Gong, K. Urayama, Soft Matter, 2019, 15, 3719-3732
    DOI: 10.1039/c9sm00409b
  • Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
    T. Matsuda, T. Nakajima, JP. Gong, Chem. Mater., 2019, 31, 3766-3776
    DOI: 10.1021/acs.chemmater.9b00871
  • Polyelectrolyte Complexation via Viscoelastic Phase Separation Results in Tough and Self-Recovering Porous Hydrogels
    K. Murakawa, DR. King, TL. Sun, HL. Guo, T. Kurokawa, JP. Gong, J. Mater. Chem. B, 2019, 7, 5296-5305
    DOI: 10.1039/c9tb01376h
  • Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
    J. Murat, T. Nakajima, T. Matsuda, K. Tsunoda, T. Nonoyama, T. Kurokawa, JP. Gong, Polymer, 2019, 178, 121686
    DOI: 10.1016/j.polymer.2019.121686
  • Tough Double-Network Gels and Elastomers from the Nonprestretched First Network
    T. Nakajima, Y. Ozaki, R. Namba, K. Ota, Y. Maida, T. Matsuda, T. Kurokawa, JP. Gong, ACS Macro Lett., 2019, 8, 1407-1412
    DOI: 10.1021/acsmacrolett.9b00679
  • Programmed Diffusion Induces Anisotropic Superstructures in Hydrogels with High Mechano-Optical Sensitivity
    LC. Qiao, C. Du, JP. Gong, ZL. Wu, Q. Zheng, Adv. Mater. Technol., 2019, 4, 1900665
    DOI: 10.1002/admt.201900665
  • Double Network Hydrogels Based on Semi-Rigid Polyelectrolyte Physical Networks
    R. Takahashi, T. Ikai, T. Kurokawa, DR. King, JP. Gong, J. Mater. Chem. B, 2019, 7, 6347-6354
    DOI: 10.1039/c9tb01217f
  • Fabrication of Tough Hydrogel Composites from Photoresponsive Polymers to Show Double-Network Effect
    Z. Tao, HL. Fan, JC. Huang, TL. Sun, T. Kurokawa, JP. Gong, ACS Appl. Mater. Interfaces, 2019, 11, 37139-37146
    DOI: 10.1021/acsami.9b13746
  • Shearing-Induced Contact Pattern Formation in Hydrogels Sliding in Polymer Solution
    S. Yashima, S. Hirayama, T. Kurokawa, T. Salez, H. Takefuji, W. Hong, JP. Gong, Soft Matter, 2019, 15, 1953-1959
    DOI: 10.1039/c8sm02428f
  • Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
    YN. Ye, KP. Cui, T. Indei, T. Nakajima, D. Hourdet, T. Kurokawa, JP. Gong, Macromolecules, 2019, 52, 8651-8661
    DOI: 10.1021/acs.macromol.9b01856

2018

  • Network Elasticity of a Model Hydrogel as a Function of Swelling Ratio: From Shrinking to Extreme Swelling States
    K. Hoshino, T. Nakajima, T. Matsuda, T. Sakai, JP. Gong, Soft Matter, 2018, 14, 9693-9701
    DOI: 10.1039/c8sm01854e