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Co-PI (Rubinstein Group)
Related Website

tyamamoto atmark icredd.hokudai.ac.jp

RUBINSTEIN, Michael Group
Principal Investigator
Faculty Members
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    YAMAMOTO, Tetsuya
Postdoctoral Fellows

About the Research

Research Theme

Physics of gene regulation


Gene regulation, transcription, phase separation, DNA(chromatin), interface, cell differentiation and reprogramming
Research Outline

Multicelluar organism is composed of many different types of cells although these cells have the same DNA. The specificity of cells is determined by which genes are actively expressed and which genes are repressed. We are theoretically analyzing how the dynamics of gene expression is regulated by the structure and dynamics of DNA (chromatin), RNA, and associating proteins. We are also extending our research to the physics involved in DNA replication, mitosis, and RNA splicing.

Representative Research Achievements

  • Slow chromatin dynamics enhances promoter accessibility to transcriptional condensates
    Tetsuya Yamamoto, Takahiro Sakaue, Helmut Schiessel, Nucleic Acids Research, 2021, 49,  5017-5027
    DOI: 10.1093/nar/gkab275
  • Paraspeckles are constructed as block copolymer micelles
    Tomohiro Yamazaki, Tetsuya Yamamoto, Hyura Yoshino, Sylvie Souquere, Shinichi Nakagawa, Gerard Pierron, Tetsuro Hirose, EMBO J, 2021, e107270
    DOI: 10.15252/embj.2020107270
  • Phase separation driven by production of architectural RNA transcripts
    Tetsuya Yamamoto, Tomohiro Yamazaki, Tetsuro Hirose, Soft Matter, 2020, 16, 4692-4698
    DOI: 10.1039/C9SM02458A
  • Osmotic mechanism of the loop extrusion process
    Tetsuya Yamamoto, Helmut Schiessel, PHYSICAL REVIEW E2017, 96, 030402(R)
    DOI: 10.1103/PhysRevE.96.030402
  • Transcription rates in DNA brushes
    Tetsuya Yamamoto, S. A. Safran, Soft Matter, 2015, 11, 3017-3021
    DOI: 10.1039/C4SM02871F