About the Research
Research Theme
Development of asymmetric reactions using highly confined organocatalysts
Keyword
Asymmetric Catalysis, Organocatalysis, carbonium intermediates
Research Outline
My research focuses on developing asymmetric reactions using highly confined organocatalysts, particularly those that involve carbonium intermediates, are not only intriguing from a mechanistic perspective but also have great potential for advancing synthetic methodology in organic chemistry. Additionally, I want to use computational chemistry to understand and optimize these reactions in an excellent approach, as it can provide valuable insights into reaction mechanisms, transition states, and catalyst design.
Representative Research Achievements
- Ligand-controlled copper-catalyzed Halo-Halodifluoromethylation of Alkenes and Alkynes Using Fluorinated Carboxylic Anhydrides. S. Mukherjee, Y. Aoki, S. Kawamura, M. Sodeoka, Angew. Chem. Int. Ed. 2024, 63, e202407150.
DOI : 10.1002/anie.202407150 - Difunctionalization Type Fluoroalkylations of Alkenes via Intramolecular Carbo-or Heterocycle Formation (review). S. Mukherjee, S. Kawamura, M. Sodeoka, Aldrichimica Acta. 2022, 55, 17.
- NHC-Catalyzed Desymmetrization of N-Aryl Maleimides Leading to the Atroposelective Synthesis of N-Aryl Succinimides. S. Barik, S. Shee, S. Das, R. G. Gonnade, G. Jindal,* S. Mukherjee,* A. T. Biju,* Angew. Chem. Int. Ed. 2021, 60, 12264.
DOI : 10.1002/anie.202016938 - Enantioselective N-Heterocyclic Carbene-Catalyzed Cascade Reaction for the Synthesis of Pyrroloquinolines via N–H Functionalization of Indoles. S. Mukherjee, S. Shee, T. Poisson, T. Besset, A. T. Biju, Org. Lett. 2018, 20, 6998.
DOI : 10.1021/acs.orglett.8b02820 - N-Heterocyclic Carbene-Catalyzed Michael–Michael–Lactonization Cascade for the Enantioselective Synthesis of Tricyclic δ-Lactones. S. Mukherjee, A. Ghosh, U. K. Marelli, A. T. Biju, Org. Lett. 2018, 20, 2952.
DOI : 10.1021/acs.orglett.8b00998