About the Research
Research Theme
Development of new reactions using organocatalysis
Keyword
Research Outline
Our group focuses on the development of new catalysis concepts within the areas of organocatalysis, transition metal catalysis, and, to some extent, biocatalysis. Since 1999, the List-group has concentrated on enantioselective organocatalysis as a fundamental approach complementing biocatalysis and transition metal catalysis. We have a profound interest in developing “new reactions”, designing and identifying new principles for the development of organocatalysts, expanding the scope of already developed catalysts such as proline, using organocatalysis in the synthesis of natural products and pharmaceuticals, and also investigating the mechanism by which organocatalysts activate their substrates.
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Representative Research Achievements
- Proline-Catalyzed Direct Asymmetric Aldol Reactions
B. List, R.A. Lerner, C. F. Barbas, J. Am. Chem. Soc. , 2000, 122, 2395-2396
DOI : 10.1021/ja994280y - Asymmetric Counteranion-Directed Catalysis
S. Mayer and B. List, Angew. Chem. Int. Ed. 45, 2006, 4193-4195
DOI : 10.1002/anie.200600512 - Asymmetric Spiroacetalization Catalysed by Confined Brønsted Acids
Ilija Čorić and Benjamin List, Nature, 2012, 483 (7389), 315- 319
DOI : 10.1038/nature10932 - Extremely Active Organocatalysts Enable a Highly Enantioselective Addition of Allyltrimethylsilane to Aldehydes
Philip S. J. Kaib, Lucas Schreyer, Sunggi Lee, Roberta Properzi and Benjamin List, Angew. Chem. Int. Ed., 2016, 55 (42), 13200-13203
DOI : 10.1002/anie.201607828 - Activation of olefins via asymmetric Brønsted acid catalysis
Nobuya Tsuji, Jennifer L. Kennemur, Thomas Buyck, Sunggi Lee, Sébastien Prévost, Philip S. J. Kaib, Dmytro Bykov, Christophe Farès and Benjamin List, Science, 2018, 359, 1501–1505
DOI : 10.1126/science.aaq0445