LIST, Benjamin

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LIST, Benjamin
Principal Investigator, Professor
Director and Professor at the Max-Planck-Institut fuer Kohlenforschung
Honorary Professor at the University of Cologne
Recipient of the 2021 Nobel Prize in Chemistry
Research Areas
Reaction Design, New reactions with organocatalysts and/or small molecules
Related Website

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LIST, Benjamin Group
Principal Investigator
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    LIST, Benjamin
Faculty Members
Postdoctoral Fellows
  • YAMAGUCHI, Mayumi

About the Research

Research Theme

Development of new reactions using organocatalysis



Research Outline

Our group focuses on the development of new catalysis concepts within the areas of organocatalysis, transition metal catalysis, and, to some extent, biocatalysis. Since 1999, the List-group has concentrated on enantioselective organocatalysis as a fundamental approach complementing biocatalysis and transition metal catalysis. We have a profound interest in developing “new reactions”, designing and identifying new principles for the development of organocatalysts, expanding the scope of already developed catalysts such as proline, using organocatalysis in the synthesis of natural products and pharmaceuticals, and also investigating the mechanism by which organocatalysts activate their substrates.

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Representative Research Achievements

  • Proline-Catalyzed Direct Asymmetric Aldol Reactions
    B. List, R.A. Lerner, C. F. Barbas, J. Am. Chem. Soc. , 2000, 122, 2395-2396
    DOI : 10.1021/ja994280y
  • Asymmetric Counteranion-Directed Catalysis
    S. Mayer and B. List, Angew. Chem. Int. Ed. 45, 2006, 4193-4195
    DOI : 10.1002/anie.200600512
  • Asymmetric Spiroacetalization Catalysed by Confined Brønsted Acids
    Ilija Čorić and Benjamin List, Nature, 2012, 483 (7389), 315- 319
    DOI : 10.1038/nature10932
  • Extremely Active Organocatalysts Enable a Highly Enantioselective Addition of Allyltrimethylsilane to Aldehydes
    Philip S. J. Kaib, Lucas Schreyer, Sunggi Lee, Roberta Properzi and Benjamin List, Angew. Chem. Int. Ed., 2016, 55 (42), 13200-13203
    DOI : 10.1002/anie.201607828
  • Activation of olefins via asymmetric Brønsted acid catalysis
    Nobuya Tsuji, Jennifer L. Kennemur, Thomas Buyck, Sunggi Lee, Sébastien Prévost,  Philip S. J. Kaib, Dmytro Bykov, Christophe Farès and Benjamin List, Science, 2018, 359, 1501–1505
    DOI : 10.1126/science.aaq0445

Related Research



  • Catalytic Asymmetric Cationic Shifts of Aliphatic Hydrocarbons
    V. N. Wakchaure, W. DeSnoo, C. J. Laconsay, M. Leutzsch, N. Tsuji, D. J. Tantillo, B. List, Nature, 2024, 625,
    DOI: 10.1038/s41586-023-06826-7


  • A Catalytic Asymmetric Hydrolactonization
    R. Maji, S. Ghosh, O. Grossmann, P. L. Zhang, M. Leutzsch, N. Tsuji, B. List, J. Am. Chem. Soc., 2023, 145, 16, 8788–8793
    DOI: 10.1021/jacs.3c01404
  • Organocatalytic DYKAT of Si-Stereogenic Silanes
    H. Zhou, R. Properzi, M. Leutzsch, P. Belanzoni, G. Bistoni, N. Tsuji, J. T. Han, C. D. Zhu, B. List, J. Am. Chem. Soc., 2023, 145, 9, 4994–5000
    DOI: 10.1021/jacs.3c00858
  • Predicting Highly Enantioselective Catalysts Using Tunable Fragment Descriptors
    N. Tsuji, P. Sidorov, C. D. Zhu, Y. Nagata, T. Gimadiev, A. Varnek, B. List, Angew. Chem., Int. Ed., 2023, ,
    DOI: 10.1002/anie.202218659


  • Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silyl Ethers
    H. Zhou, J. T. Han, N. Nothling, M. M. Lindner, J. Jenniches, C. Kuhn, N. Tsuji, L. Zhang, B. List, J. Am. Chem. Soc., 2022, 144, 10156-10161
    DOI: 10.1021/jacs.2c04261
  • Design of an Organocatalytic Asymmetric (4+3) Cycloaddition Of2-Indolylalcohols with Dienolsilanes Br
    J. Ouyang, R. Maji, M. Leutzsch, B. Mitschke, B. List, J. Am. Chem. Soc., 2022, 144, 8460-8466
    DOI: 10.1021/jacs.2c02216


  • Catalytic Asymmetric Additions of Enol Silanes to In Situ Generated Cyclic, Aliphatic N-Acyliminium Ions
    O. Grossmann, R. Maji, M. H. Aukland, S. Lee, B. List, Angew. Chem., Int. Ed., 2021, 61,
    DOI: 10.1002/anie.202115036
  • Confinement-Controlled, Either Syn- or Anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
    T. Amatov, N. Tsuji, R. Maji, L. Schreyer, H. Zhou, M. Leutzsch, B. List, J. Am. Chem. Soc., 2021, 143, 14475-14481
    DOI: 10.1021/jacs.1c07447
  • Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles
    P. L. Zhang, N. Tsuji, J. Ouyang, B. List, J. Am. Chem. Soc., 2021, 143, 675-680
    DOI: 10.1021/jacs.0c12042