About the Research
Research Theme
Development of new organocatalytic acid-catalyzed reactions
Keyword
Asymmetric catalysis, Organocatalysis, Brønsted acid, Lewis acid catalysis
Research Outline
My research aims towards the discovery of new reactions by using selective catalysis based on small organic molecules, aka. organocatalysts. Due to the vast number of reactions that can be catalyzed by acids, the main focus of my research is the development and application of chiral organic acids for asymmetric counteranion-directed catalysis (ACDC), towards the expansion and generalization of available substrate classes by the rational and data-driven development of confined and even more active yet highly selective catalyst motifs.
Representative Research Achievements
- Direct access to tetrasubstituted cyclopentenyl scaffolds through a diastereoselective isocyanide-based multicomponent reaction
V. A. Fernandes, R. N. Lima, Y. B. Broterson, M. Y. Kawamura, R. Echemendía, A. F. de la Torre, M. A. B. Ferreira, D. G. Rivera, M. W. Paixão. Chem. Sci., 2021, 12, 15862-15869.
DOI: 10.1039/D1SC04158D - Electrochemical Installation of CFH2−, CF2H−, CF3−, and Perfluoroalkyl Groups into Small Organic Molecules
C. M. Kisukuri, V. A. Fernandes, J. A. C. Delgado, A. P. Häring, M. W. Paixão, S. R. Waldvogel. Chem. Rec., 2021, 21, 2502-2525.
DOI: 10.1002/tcr.202100065 - Synthesis of N-alkylated lipopeptides and their application as organocatalysts in asymmetric Michael addition in aqueous environments
J. A. C. Delgado, F. E. M. Vicente, A. F. de la Torre, V. A. Fernandes, A. G. Corrêa, M. W. Paixão. New J. Chem., 2021, 45, 14050-14057.
DOI: 10.1039/D1NJ01112J - Photoinduced deaminative strategies: Katritzky salts as alkyl radical precursors
J. T. M. Correia, V. A. Fernandes, B. T. Matsuo, J. A. C. Delgado, W. C. de Souza, M. W. Paixão. Chem. Commun., 2020, 56, 503-514.
DOI: 10.1039/C9CC08348K