About the Research
Research Theme
Computational Science-Driven Strategy for the Development of Chemical Reactions, Chemical Synthesis of β-Amino Acids Using CO₂
Representative Research Achievements
- Photocatalytic Activation of Fluoroform for Radical Trifluoromethylation
Zhou, S.; Song, Y.; Harabuchi, Y.; Kanna, W.; Katsuyama, H.; Cooper, S. J.; Tanaka, K., III; Mita, T.; Maeda, S.; Hayashi, H. J. Am. Chem. Soc. 2026, 148, 34907 – 34915.
DOI : 10.1021/jacs.6c10939 - Tandem Reactivity of Metal−Carbon and Carbon−Silicon Bonds in Mononuclear α-Silyl Organolithium or Organosodium Complexes Towards CO, CO2 and Heteroallenes
Yang, X.; Hemingway, J. M.; Kanna, W.; Davison, N.; Hayashi, H.; Male, L.; Waddell, P. G.; Dawson, J. A.; Lu, E. Angew. Chem. Int. Ed. 2026, 65, e8906317.
DOI : 10.1002/anie.8906317 - Identifying Viable Synthetic Routes from Side Channels in Automated Reaction-path Searches
Ueno, Y.; Kanna, W.; Harabuchi, Y.; Tanaka, K., III; Cooper, S. J.; Staub, R.; Varnek, A.; Maeda, S.; Mita, T. Commun. Chem. 2026.
DOI : 10.1038/s42004-026-02114-3 - Virtual Ligand-Assisted Screening for the Generation of Ketyl Radicals from Alkyl Ketones via Photoexcited Palladium Catalysis
Tanaka, K., III; Yamada, R.; Debbarma, S.; Kanna, W.; Hayashi, H.; Matsuoka, W.; Maeda, S.; Mita, T. J. Am. Chem. Soc. 2025, 147, 39640 – 39651.
DOI : 10.1021/jacs.5c13115 - Computationally Guided Development of an Alkene Aminocarboxylation with CO2: Synthesis of a β-Amino Acid Derivative
Kanna, W.; Harabuchi, Y.; Tanaka, K., III; Hayashi, H.; Takano, H.; Kozuka, T.; Sakurai, H.; Mase, N.; Maeda, S.; Mita, T. ACS Catal. 2025, 15, 12180 – 12191.
DOI : 10.1021/acscatal.5c03580
Related Research
Publications
2026
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Tandem Reactivity of Metal-Carbon and Carbon-Silicon Bonds in Mononuclear α-Silyl Organolithium or Organosodium Complexes Towards CO, CO2 and Heteroallenes
, J. Hemingway, W. Kanna, N. Davison, H. Hayashi, L. Male, P. Waddell, J. Dawson, E. Lu, Angew. Chem., Int. Ed., 2026, ,
DOI: 10.1002/anie.8906317