HUANG, Dennis Chung-Yang

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HUANG, Dennis Chung-Yang
Junior PI, Associate Professor
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HUANG, Dennis Chung-Yang Group
Junior PI
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    HUANG, Dennis Chung-Yang
Postdoctoral Fellows

About the Research

Research Theme

Synthesis and application of functional organic molecules


Organic synthesis, transition metal catalysis, photochemistry
Research Outline

As a group focusing on functional organic chemistry, we will be working on the following two areas: (1) development of new synthetic methodologies using modern techniques in organic synthesis and transition metal catalysis, and (2) preparation of photoresponsive molecules and the study of their functions. In particular, we will work collaboratively with other research groups to implement approaches in theoretical calculations as well as machine learning to faciliate the molecular design and mechanistic understanding.

Research History

Please see CV (updated August 2022).

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Representative Research Achievements

N,N’-Disubstituted Indigos as Readily Available Red-Light Photoswitches with Tunable Thermal Half-Lives. C.-Y. Huang, A. Bonasera, L. Hristov, Y. Garmshausen, B. M. Schmidt, D. Jacquemin, S. Hecht, J. Am. Chem. Soc., 2017, 139, 15205–15211.
DOI: 10.1021/jacs.7b08726

Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines. B. P. Woods, M. Orlandi, C.-Y. Huang, M. S. Sigman, A. G. Doyle, J. Am. Chem. Soc., 2017, 139, 5688–5691. DOI: 10.1021/jacs.7b03448

Electron-Deficient Olefin Ligands Enable Generation of Quaternary Carbons by Ni-Catalyzed Cross-Coupling. C.-Y. Huang, A. G. Doyle, J. Am. Chem. Soc., 2015, 137, 5638–5641.
DOI: 10.1021/jacs.5b02503

The Chemistry of Transition Metals with Three-Membered Ring Heterocycles. C.-Y. Huang, A. G. Doyle, Chem. Rev., 2014, 114, 8153–8198. DOI: 10.1021/cr500036t

Nickel-Catalyzed Negishi Alkylations of Styrenyl Aziridines. C.-Y. Huang, A. G. Doyle, J. Am. Chem. Soc., 2012, 134, 9541–9544. DOI: 10.1021/ja3013825

Related Research



  • Direct a-Trifluoromethylthiolation of Carboxylic Acids Enabled by Boron Catalysis
    K. Sun, C. Y. D. Huang, M. Sawamura, Y. Shimizu, Synlett, 2023, ,
    DOI: 10.1055/a-2071-4465
  • A Blueprint for Transforming Indigos to Photoresponsive Molecular Tools
    C. Y. Huang, S. Hecht, Chem. Eur. J., 2023, ,
    DOI: 10.1002/chem.202300981
  • Red-Light Photoswitching of Indigos in Polymer Thin Films
    K. Kuntze, J. Viljakka, M. Virkki, C. Y. Huang, S. Hecht, A. Priimagi, Chem. Sci., 2023, ,
    DOI: 10.1039/d2sc06790k


  • Mechanistic Insights into the Photoisomerization of N,N '-Disubstituted Indigos
    S. Budzak, J. Jovaisaite, C. Y. Huang, P. Baronas, K. Tulaite, S. Jursenas, D. Jacquemin, S. Hecht, Chem. Eur. J., 2022, 28,
    DOI: 10.1002/chem.202200496