About the Research
Research Theme
Analysis of the tumor microenvironment using biomaterials and development of novel diagnostic and therapeutic strategies
Keyword
cancer, tumor microenvironment, cancer stem cell, pathology, biomaterial
Research Outline
In ICReDD Fusion Research, my research focuses on achieving a deeper understanding of cancer pathology and developing novel diagnostic and therapeutic targets through the analysis of cellular responses, underlying molecular mechanisms, and cell–cell interactions using biomaterials, together with pathological tissue analysis.
Representative Research Achievements
- Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contribute to Distinct Vascular Structures
Shirai Y, Tsuda M, Wang L, Oda Y, Sugizno H, Tanei ZI, Gong JP, Tanaka S,
Pathol. Int., 2026, 76, e70099
DOI: 10.1111/pin.70099 - An Autopsy Case of Amyotrophic Lateral Sclerosis With Sudden Death Showed Histological Features of Lewy Body Disease
Miyachi S, Oshima Y, Yazaki K, Futaki N, Shirai Y, Tanei ZI, Ikebe Y, Iwata I, Ujiie H, Onozawa M, Hirano S, Tanaka S, & Yabe I,
Neuropathology, 2025, 45, e70009
DOI: 10.1111/neup.70009 - Aneurysmal rupture in microscopic polyangiitis: a case-based review
Imanishi K, Yasuo K, Shirai Y, Tanikawa S, Uchizawa M, Nishibata Y, Masuda S, Tanei ZI, Tanaka S, & Ishizu A,
Clin. rheumatol., 2025, 44, 1345–1354
DOI: 10.1007/s10067-025-07319-w - Pitfall of the Diagnosis of Extramedullary Tumor: A Case of Intracranial Mesenchymal Tumor, FET::CREB Fusion-Positive Occurring in an Atypical Clinical Setting
Oda Y, Seo Y, Masumoto Y, Mori T, Kuwabara T, Ise K, Shirai Y, Sugino H, Okada H, Tanei ZI, Wang L, Asayama B, Sato S, Kikuchi Y, Tsuda M, Oda Y, Tanaka S,
Pathol Int., 2026, 76, e70064
DOI: 10.1111/pin.70064 - Histopathology of an autopsy case of a leadless pacemaker system: a case report
Misonou K, Doi T, Shirai Y, Nagahara D,
Eur Heart J Case Rep., 2024, 8, ytae120.
DOI: 10.1093/ehjcr/ytae120