TSUDA, Masumi

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TSUDA, Masumi

About the Research

Research Theme

Development of novel diagnostic and therapeutic methods for cancer and innovative regenerative medicine by biomaterials


Cancer, Cancer Stem Cells, Molecular Targeted Therapy, Genetic Diagnosis, Regenerative Medicine, Biomaterial
Research Outline

Through analysis of cell dynamics and bioreactivity using biomaterials, we aim to deeply understand diseases, develop new diagnostic and therapeutic methods for cancer, and establish innovative regenerative medicine for medical applications.

Representative Research Achievements

  • Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
    Yoshida K, Tsuda M, Matsumoto R, Semba S, Wang L, Sugino H, Tanino M, Kondo T, Tanabe K, Tanaka S., Cancer Sci, 2019, 110, 2119-2132
    DOI: 10.1111/cas.14080
  • A Ca(2+)-dependent signaling circuit regulates influenza A virus internalization and infection
    Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y., Nat Commun, 2013, 4, 2763
    DOI: 10.1038/ncomms3763
  • Crk adaptor protein induced-phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration
    Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S., Cell Res, 2009, 19, 638-650
    DOI: 10.1038/cr.2009.40
  • TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition 
    Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M., Cancer Res, 2007, 67, 919-929
    DOI: 10.1158/0008-5472.CAN-06-2855
  • Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1
    Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, Akagi T, Isobe K, Nagashima K, Tanaka S., Oncogene, 2005, 24, 7984-7990
    DOI: 10.1038/sj.onc.1208942

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