Hokkaido University Institute for Chemical Reaction Design and Discovery

Research Outline

Through analysis of cell dynamics and bioreactivity using biomaterials, we aim to deeply understand diseases, develop new diagnostic and therapeutic methods for cancer, and establish innovative regenerative medicine for medical applications.

Representative Research Achievements

• Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
  Yoshida K, Tsuda M, Matsumoto R, Semba S, Wang L, Sugino H, Tanino M, Kondo T, Tanabe K, Tanaka S., Cancer Sci, 2019, 110, 2119-2132
  DOI: 10.1111/cas.14080
• A Ca(2+)-dependent signaling circuit regulates influenza A virus internalization and infection
  Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y., Nat Commun, 2013, 4, 2763
  DOI: 10.1038/ncomms3763
• Crk adaptor protein induced-phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration
  Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S., Cell Res, 2009, 19, 638-650
  DOI: 10.1038/cr.2009.40
• TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition 
  Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M., Cancer Res, 2007, 67, 919-929
  DOI: 10.1158/0008-5472.CAN-06-2855
• Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1
  Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, Akagi T, Isobe K, Nagashima K, Tanaka S., Oncogene, 2005, 24, 7984-7990
  DOI: 10.1038/sj.onc.1208942