About the Research
Research Theme
Development of novel diagnostic and therapeutic methods for cancer and innovative regenerative medicine by biomaterials
Keyword
Cancer, Cancer Stem Cells, Molecular Targeted Therapy, Genetic Diagnosis, Regenerative Medicine, Biomaterial
Research Outline
Through analysis of cell dynamics and bioreactivity using biomaterials, we aim to deeply understand diseases, develop new diagnostic and therapeutic methods for cancer, and establish innovative regenerative medicine for medical applications.
Representative Research Achievements
- Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
Yoshida K, Tsuda M, Matsumoto R, Semba S, Wang L, Sugino H, Tanino M, Kondo T, Tanabe K, Tanaka S., Cancer Sci, 2019, 110, 2119-2132
DOI: 10.1111/cas.14080 - A Ca(2+)-dependent signaling circuit regulates influenza A virus internalization and infection
Fujioka Y, Tsuda M, Nanbo A, Hattori T, Sasaki J, Sasaki T, Miyazaki T, Ohba Y., Nat Commun, 2013, 4, 2763
DOI: 10.1038/ncomms3763 - Crk adaptor protein induced-phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration
Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S., Cell Res, 2009, 19, 638-650
DOI: 10.1038/cr.2009.40 - TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition
Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M., Cancer Res, 2007, 67, 919-929
DOI: 10.1158/0008-5472.CAN-06-2855 - Induction of p21(WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1
Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, Akagi T, Isobe K, Nagashima K, Tanaka S., Oncogene, 2005, 24, 7984-7990
DOI: 10.1038/sj.onc.1208942
Related Research
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- New method enables spatial detection of regulatory factors associated with cancer tumor invasion
- One step closer to artificial cartilage. Hydrogels show signs of triggering bone marrow stem cells to change into bone-like cells
- Mutation in COVID Delta variant associated with increased pathogenicity and fusogenicity
- Uprooting cancer: Hydrogel rapidly reverts cancer cells back to cancer stem cells