TANAKA, Shinya

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TANAKA, Shinya
Principal Investigator, Professor
Hokkaido University
Research Areas
Tumor Pathology, Cell control by new material(s), machine learning, and complex molecules
Related Website

tanaka atmark med.hokudai.ac.jp

TANAKA, Shinya Group
Principal Investigator
  • thumbnail image
    TANAKA, Shinya
Faculty Members
Postdoctoral Fellows
Research Collaborators

About the Research

Research Theme

Cell control by new materials, development of new generation diagnosis and therapy


Biomedical engineering, Cellular reprogramming, Molecular biology, Cancer pathology, Regenerative medicine

Research Outline

The research in our laboratory aims at utilizing hydrogels as biomaterials to control the phenotypes of cells. The hydrogels’ physical factors, such as charge and elastic modulus, depend on the nature and structure of the monomer molecules and gels with certain conditions cause cells to undergo characteristic changes. For example, cancer stem cells, the cause of cancer recurrence, are produced by special hydrogels in a matter of 24 hours, while this process takes more than 10 days with conventional culture techniques. This leads to the development of new cancer diagnostic tools and treatments. Another kind of hydrogel has been shown to control neuronal regeneration. Based on this, we aim to develop new approaches in regenerative medicine.

At ICReDD, we have a particularly strong collaboration with Dr. Jian Ping Gong, who develops the hydrogels, to develop new gels that can be applied to clinical medicine, and with the experts in information science and computational chemistry to develop new diagnostic tools and therapeutics by controlling cells with hydrogels. The results of these collaborations will create a new integrated research field we call “material genomics”.

The Researcher’s Perspective

A Japanese saying (“Ichi-go, ichi-e”) that originates from the tea ceremony emphazises that meeting a person is a once-in-a-lifetime chance and should be cherished as such. I like that saying, and so I make sure that in our lab we have many kinds of activities to foster such interactions, besides the usual scientific work. ICReDD itself is a manifestation of this idea by encouraging human encounters where new ideas will come up. ICReDD has mixed-labs and I cherish the chance of human encounters and would like to develop a new research field.

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Representative Research Achievements

  • Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels.
    Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S, Nat Biomed Eng. 2021 Aug;5(8):914-925.
    DOI: 10.1038/s41551-021-00692-2.
  • Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.
    Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M; Genotype to Phenotype Japan (G2P-Japan) Consortium, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K, Nature. 2021 Nov 25.
    DOI: 10.1038/s41586-021-04266-9
  • Synthetic poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function.
    Semba S, Kitamura N, Tsuda M, Goto K, Kurono S, Ohmiya Y, Kurokawa T, Gong JP, Yasuda K, Tanaka S. J Biomed Mater Res A, 2021 Mar;109(3):354-364.
    DOI: 10.1002/jbm.a.37028
  • Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
    K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, and S. Tanaka, Cancer Sci, 2019, 110, 2119-2132
    DOI: 10.1111/cas.14080
  • miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition
    K. Yachi, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, and S. Tanaka, Signal Transduct and Target Ther, 2018, 3, 33
    DOI: 10.1038/s41392-018-0033-6
  • Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
    Y. Kobashigawa, M. Sakai, M. Naito, M. Yokochi, H. Kumeta, Y. Makino, K. Ogura, S. Tanaka, and F. Inagaki, Nature Structural & Molecular Biology, 2007, 14, 503-510
    DOI: 10.1038/nsmb1241

Related Research



  • Involvement of SARS-CoV-2 Accessory Proteins in Immunopathogenesis
    H. Ito, T. Tamura, L. Wang, K. Mori, M. Tsuda, R. Suzuki, S. Suzuki, K. Yoshimatsu, S. Tanaka, T. Fukuhara, MICROBIOLOGY AND IMMUNOLOGY, 2024, ,
    DOI: 10.1111/1348-0421.13157
  • Akaluc Bioluminescence Offers Superior Sensitivity to Track in Vivo Dynamics of SARS-CoV-2 Infection
    T. Tamura, H. Ito, S. Torii, L. Wang, R. Suzuki, S. Tsujino, A. Kamiyama, Y. Oda, M. Tsuda, Y. Morioka, S. Suzuki, K. Shirakawa, K. Sato, K. Yoshimatsu, Y. Matsuura, S. Iwano, S. Tanaka, T. Fukuhara, Iscience, 2024, 27(5),
    DOI: 10.1016/j.isci.2024.109647
  • Acute Eosinophilic Myocarditis Mimicking Inferior Myocardial Infarction Presenting with Delayed Hypereosinophilia
    T. Konishi, N. Funayama, D. Hotta, S. Tanaka, Cardiology Journal, 2024, 31(2), 361-362
    DOI: 10.5603/cj.96133
  • Virological Characteristics of the SARS-CoV-2 Omicron XBB.1.5 Variant
    T. Tamura, T. Irie, S. Deguchi, H. Yajima, M. Tsuda, H. Nasser, K. Mizuma, A. Plianchaisuk, S. Suzuki, K. Uriu, M. M. Begum, R. Shimizu, M. Jonathan, R. Suzuki, T. Kondo, H. Ito, A. Kamiyama, K. Yoshimatsu, M. Shofa, R. Hashimoto, Y. Anraku, K. T. Kimura, S. Kita, J. Sasaki, K. Sasaki-Tabata, K. Maenaka, N. Nao, L. Wang, Y. Oda, H. Sawa, R. Kawabata, Y. Watanabe, A. Sakamoto, N. Yasuhara, T. Suzuki, Y. Nakajima, Z. Ferdous, K. Shishido, Y. Mugita, O. Takahashi, K. Ichihara, Y. Kaku, N. Misawa, Z. Y. Guo, A. Hinay, Y. Kosugi, S. Fujita, J. M. Tolentino, L. Chen, L. Pan, M. Suganami, M. Chiba, R. Yoshimura, K. Yasuda, K. Iida, N. Ohsumi, A. P. Strange, Y. Shibatani, T. Nishiuchi, S. Tanaka, O. Putri, G. Joas, Y. Kim, D. Yamasoba, K. Yoshimura, K. Sadamasu, M. Nagashima, H. Asakura, I. Yoshida, S. Nakagawa, A. Takaori-Kondo, K. Shirakawa, K. Nagata, R. Nomura, Y. Horisawa, Y. Tashiro, Y. Kawai, T. Ueno, C. Motozono, M. Toyoda, T. Ikeda, A. Saito, K. Matsuno, J. Ito, K. Sato, T. Hashiguchi, K. Takayama, T. Fukuhara, G. P. Genotype Phenotype Japan, Nat. Commun., 2024, 15,
    DOI: 10.1038/s41467-024-45274-3
  • Targeted Demethylation and Activation of NLRC5 Augment Cancer Immunogenicity through MHC Class I
    X. Sun, T. Watanabe, Y. Oda, W. D. Shen, A. Ahmad, R. Ouda, P. de Figueiredo, H. Kitamura, S. Tanaka, K. S. Kobayashi, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121, (6), e2310821121
    DOI: 10.1073/pnas.2310821121
  • Structure-Changeable Luminescent Eu(III) Complex as a Human Cancer Grade Probing System for Brain Tumor Diagnosis
    M. F. Wang, M. Kono, Y. Yamaguchi, J. Islam, S. Shoji, Y. Kitagawa, K. Fushimi, S. Watanabe, G. Matsuba, A. Yamamoto, M. Tanaka, M. Tsuda, S. Tanaka, Y. Hasegawa, Scientific Reports, 2024, 14, Article number: 778
    DOI: 10.1038/s41598-023-50138-9
  • A Case of Uterine Tumor Resembling Ovarian Sex Cord Tumor With Prominent Myxoid Features
    K. Ise, Z. Tanei, Y. Oda, S. Tanikawa, H. Sugino, Y. Ishida, M. Tsuda, Y. Gotoda, K. Nishiwaki, H. Yanai, T. Hasegawa, K. Nagashima, S. Tanaka, International Journal of Gynecological Pathology, 2024, 43, 41-46
    DOI: 10.1097/pgp.0000000000000949


  • Fibrinous Pericarditis Secondary to Recurrent Acute Myeloid Leukaemia
    T. Konishi, T. Kimura, K. Minauchi, S. Tanaka, European Heart Journal-Case Reports, 2023, 7, 11
    DOI: 10.1093/ehjcr/ytad537
  • Multimodality Imaging Approach to an Adult Case with Cor Triatriatum Sinister
    T. Konishi, N. Funayama, D. Hotta, S. Tanaka, Cardiology Journal, 2023, 30, 1057-1058
    DOI: 10.5603/cj.96262
  • Association of Coronary Plaque Morphology with Inflammatory Biomarkers and Target Lesion Revascularization in Patients with Chronic Coronary Syndrome: An Optical Coherence Tomography Study
    Saiin, K., Konishi, T., Kazui, S., Yasui, Y., Takahashi, Y., Naito, S., Takenaka, S., Mizuguchi, Y., Tada, A., Kobayashi, Y., Kato, Y., Omote, K., Sato, T., Kamiya, K., Nagai, T., Tanaka, S., Anzai, T., American Journal of Cardiovascular Disease, 2023, 13, (5), 309-319
  • Lethal Complication: Ventricular Septal Perforation and Right Ventricular Infarction after Acute Myocardial Infarction
    T. Konishi, N. Funayama, T. Yamamoto, D. Hotta, S. Tanaka, Clinical Case Reports, 2023, 11,
    DOI: 10.1002/ccr3.7994
  • Deep Vein Thrombosis Due to Left Iliac Vein Compression Syndrome Complicated by Acute Pulmonary Thromboembolism and Cerebral Infarction
    T. Konishi, N. Funayama, D. Hotta, S. Tanaka, Acta Cardiologica, 2023, ,
    DOI: 10.1080/00015385.2023.2250945
  • Comparative Pathogenicity of SARS-CoV-2 Omicron Subvariants Including BA.1, BA.2, and BA.5
    T. Tamura, D. Yamasoba, Y. Oda, J. Ito, T. Kamasaki, N. Nao, R. Hashimoto, Y. Fujioka, R. Suzuki, L. Wang, H. Ito, Y. Kashima, I. Kimura, M. Kishimoto, M. Tsuda, H. Sawa, K. Yoshimatsu, Y. Yamamoto, T. Nagamoto, J. Kanamune, Y. Suzuki, Y. Ohba, I. Yokota, K. Matsuno, K. Takayama, S. Tanaka, K. Sato, T. Fukuhara, G. P. J. Genotype Phenotype Japan, Communications Biology, 2023, 6, Article number: 772
    DOI: 10.1038/s42003-023-05081-w
  • Increased Piezo1 Expression in Myofibroblasts in Patients with Symptomatic Carotid Atherosclerotic Plaques Undergoing Carotid Endarterectomy: A Pilot Study
    T. Konishi, K. Kamiyama, T. Osato, T. Yoshimoto, T. Aoki, T. Anzai, S. Tanaka, Vascular, 2023, ,
    DOI: 10.1177/17085381231192380
  • Convergent Evolution of SARS-CoV-2 Omicron Subvariants Leading to the Emergence of BQ.1.1 Variant
    J. Ito, R. Suzuki, K. Uriu, Y. Itakura, J. Zahradnik, K. T. Kimura, S. Deguchi, L. Wang, S. Lytras, T. Tamura, I. Kida, H. Nasser, M. Shofa, M. M. Begum, M. Tsuda, Y. Oda, T. Suzuki, J. Sasaki, K. Sasaki-Tabata, S. Fujita, K. Yoshimatsu, H. Ito, N. Nao, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, Y. Yamamoto, T. Nagamoto, J. Kuramochi, G. Schreiber, A. Saito, K. Matsuno, K. Takayama, T. Hashiguchi, S. Tanaka, T. Fukuhara, T. Ikeda, K. Sato, S. Suzuki, M. Kato, Z. Ferdous, H. Mouri, K. Shishido, N. Misawa, I. Kimura, Y. Kosugi, P. Lin, M. Suganami, M. Chiba, R. Yoshimura, K. Yasuda, K. Iida, N. Ohsumi, A. P. Strange, D. Sauter, S. Nakagawa, J. Q. Wu, Y. Watanabe, A. Sakamoto, N. Yasuhara, Y. Nakajima, H. Yajima, K. Shirakawa, A. Takaori-Kondo, K. Nagata, Y. Kazuma, R. Nomura, Y. Horisawa, Y. Tashiro, Y. Kawa, T. Irie, R. Kawabata, R. Shimizu, O. Takahashi, K. Ichihara, C. Motozono, M. Toyoda, T. Ueno, Y. Shibatani, T. Nishiuchi, G. P. J. Genotype Phenotype Japan, Nat. Commun., 2023, 14, 2671,
    DOI: 10.1038/s41467-023-38188-z
  • Virological Characteristics of the SARS-CoV-2 XBB Variant Derived from Recombination of Two Omicron Subvariants
    T. Tamura, J. Ito, K. Uriu, J. Zahradnik, I. Kida, Y. Anraku, H. Nasser, M. Shofa, Y. Oda, S. Lytras, N. Nao, Y. Itakura, S. Deguchi, R. Suzuki, L. Wang, M. Begum, S. Kita, H. Yajima, J. Sasaki, K. Sasaki-Tabata, R. Shimizu, M. Tsuda, Y. Kosugi, S. Fujita, L. Pan, D. Sauter, K. Yoshimatsu, S. Suzuki, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, Y. Yamamoto, T. Nagamoto, G. Schreiber, K. Maenaka, T. Hashiguchi, T. Ikeda, T. Fukuhara, A. Saito, S. Tanaka, K. Matsuno, K. Takayama, K. Sato, G. P. J. Genotype Phenotype Japan, Nat. Commun., 2023, 14, 2671
    DOI: 10.1038/s41467-023-38435-3
  • New Onset of Hypomegakaryocytic Thrombocytopenia with the Potential for Progression to Aplastic Anemia after BNT162b2 mRNA COVID-19 Vaccination
    M. Kobayashi, A. Mori, Y. Oda, E. Yokoyama, M. Kanaya, K. Izumiyama, M. Saito, S. Tanaka, M. Morioka, T. Kondo, International Journal of Hematology, 2023, ,
    DOI: 10.1007/s12185-023-03618-7
  • Symptomatic Bilateral Complete Discoid Medial Menisci of the Knee in a Child: A Case Report
    Y. Suzuki, E. Kondo, T. Kaibara, M. Matsuoka, R. Hishimura, K. Iwasaki, T. Onodera, D. Momma, S. Tanaka, N. Iwasaki, Joint Diseases and Related Surgery, 2023, 34, (2), 455-462
    DOI: 10.52312/jdrs.2023.999
  • Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction
    Tanikawa, S, Ebisu, Y, Sedlacík, T, Semba, S, Nonoyama, T, Kurokawa, T, Hirota, A, Takahashi, T, Yamaguchi, K, Imajo, M, Kato, H, Nishimura, T, Tanei, ZI, Tsuda, M, Nemoto, T, Gong, JP, Tanaka, S, Scientific Reports, 2023, 13, (1), Article number: 2233
    DOI: 10.1038/s41598-023-28870-z
  • Combination Therapy with Bevacizumab and a CCR2 Inhibitor for Human Ovarian Cancer: An in Vivo Validation Study
    T. Y. Zhai, T. Mitamura, L. Wang, S. I. Kubota, M. Murakami, S. Tanaka, H. Watari, Cancer Medicine, 2023, ,
    DOI: 10.1002/cam4.5674
  • Geometrical Analysis Identified Morphological Features of Hydrogel- Induced Cancer Stem Cells in Synovial Sarcoma Model Cells
    Z. Ferdous, J. E. Clement, J. P. Gong, S. Tanaka, T. Komatsuzaki, M. Tsuda, Biochemical and Biophysical Research Communications, 2023, 642, 41-49
    DOI: 10.1016/j.bbrc.2022.12.040


  • ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells
    A. Hirota, J. E. Clement, S. Tanikawa, T. Nonoyama, T. Komatsuzaki, J. P. Gong, S. Tanaka, M. Imajo, Cancers, 2022, 14,
    DOI: 10.3390/cancers14235890
  • Neutrophil Phenotypes Implicated in the Pathophysiology of Post-Traumatic Sepsis
    A. Mizugaki, T. Wada, T. Tsuchida, Y. Oda, K. Kayano, K. Yamakawa, S. Tanaka, Frontiers in Medicine, 2022, 9,
    DOI: 10.3389/fmed.2022.982399
  • Germline PRDM1 Variant Rs2185379 in Long-Term Recurrence-Free Survivors of Advanced Ovarian Cancer
    T. Mitamura, T. Zhai, K. C. Hatanaka, Y. Hatanaka, T. Amano, L. Wang, S. Tanaka, H. Watari, Pharmacogenomics & Personalized Medicine, 2022, 15, 977-984
    DOI: 10.2147/pgpm.s387120
  • Intraoperative Rapid Immunohistochemistry with Noncontact Antibody Mixing for Undiagnosed Pulmonary Tumors
    K. Imai, H. Nanjo, W. Shigeeda, T. Sugai, T. Ito, Y. Maniwa, S. Takashima, H. Saito, N. Yanagawa, Y. Tanaka, T. Doi, Y. Hiroshima, K. Nomura, M. Tanino, S. Tanaka, Y. Minamiya, R. I. S. Grp, Cancer Sci., 2022, ,
    DOI: 10.1111/cas.15616
  • Virological Characteristics of the SARS-CoV-2 Omicron BA.2 Subvariants, Including BA.4 and BA.5
    I. Kimura, D. Yamasoba, T. Tamura, N. Nao, T. Suzuki, Y. Oda, S. Mitoma, J. Ito, H. Nasser, J. Zahradnik, K. Uriu, S. Fujita, Y. Kosugi, L. Wang, M. Tsuda, M. Kishimoto, H. Ito, R. Suzuki, R. Shimizu, M. M. Begum, K. Yoshimatsu, K. T. Kimura, J. Sasaki, K. Sasaki-Tabata, Y. Yamamoto, T. Nagamoto, J. Kanamune, K. Kobiyama, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, K. Shirakawa, A. Takaori-Kondo, J. Kuramochi, G. Schreiber, K. J. Ishii, T. Hashiguchi, T. Ikeda, A. Saito, T. Fukuhara, S. Tanaka, K. Matsuno, K. Sato, G. P. J. Genotype Phenotype Japan, Cell, 2022, 185, 3992-4007.e16
    DOI: 10.1016/j.cell.2022.09.018
  • Force-Triggered Rapid Microstructure Growth on Hydrogel Surface for On-Demand Functions
    Q. F. Mu, K. P. Cui, Z. J. Wang, T. Matsuda, W. Cui, H. Kato, S. Namiki, T. Yamazaki, M. Frauenlob, T. Nonoyama, M. Tsuda, S. Tanaka, T. Nakajima, J. P. Gong, Nat. Commun., 2022, 13,
    DOI: 10.1038/s41467-022-34044-8
  • An Autopsy Case Report of Adult-Onset Krabbe Disease: Comparison with an Infantile-Onset Case
    M. Sasaki, M. Ebata, Z. Tanei, Y. Oda, A. Hamauchi, S. Tanikawa, H. Sugino, Y. Ishida, T. Abe, N. Arai, K. Sako, S. Tanaka, Pathology International, 2022, ,
    DOI: 10.1111/pin.13275
  • Virological Characteristics of the SARS-CoV-2 Omicron BA.2.75 Variant
    A. Saito, T. Tamura, J. Zahradnik, S. Deguchi, K. Tabata, Y. Anraku, I. Kimura, J. Ito, D. Yamasoba, H. Nasser, M. Toyoda, K. Nagata, K. Uriu, Y. Kosugi, S. Fujita, M. Shofa, M. M. Begum, R. Shimizu, Y. Oda, R. Suzuki, H. Ito, N. Nao, L. Wang, M. Tsuda, K. Yoshimatsu, J. Kuramochi, S. Kita, K. Sasaki-Tabata, H. Fukuhara, K. Maenaka, Y. Yamamoto, T. Nagamoto, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, T. Ueno, G. Schreiber, A. Takaori-Kondo, K. Shirakawa, H. Sawa, T. Irie, T. Hashiguchi, K. Takayama, K. Matsuno, S. Tanaka, T. Ikeda, T. Fukuhara, K. Sato, G. P. J. Genotype Phenotype Japan, Cell Host & Microbe, 2022, 30, 1540-+
    DOI: 10.1016/j.chom.2022.10.003
  • Analysis of Clinicopathological Features and NAB2-STAT6 Fusion Variants of Meningeal Solitary Fibrous Tumor with Ectopic Salivary Gland Components in the Cerebellopontine Angle
    T. Shirakura, Y. Yamada, S. Nakata, B. Asayama, Y. Seo, S. Tanikawa, T. Kato, N. Komoribayashi, N. Kubo, N. Monma, N. Okura, S. Tanaka, Y. Oda, J. Hirato, H. Yokoo, S. Nobusawa, Virchows Archiv, 2022, ,
    DOI: 10.1007/s00428-022-03403-7
  • Evaluation of the Context of Downstream N- and Free N-Glycomic Alterations Induced by Swainsonine in HepG2 Cells
    C. Morikawa, K. Sugiura, K. Kondo, Y. Yamamoto, Y. Kojima, Y. Ozawa, H. Yoshioka, N. Miura, J. H. Piao, K. Okada, H. Hanamatsu, M. Tsuda, S. Tanaka, J. I. Furukawa, Y. Shinohara, Biochimica Et Biophysica Acta-General Subjects, 2022, 1866,
    DOI: 10.1016/j.bbagen.2022.130168
  • Neoatherosclerosis with Silent Plaque Rupture in a Saphenous Vein Graft Causing No Re-Flow Phenomenon Assessed by Optical Coherence Tomography and Histopathology
    T. Konishi, Y. Takahashi, S. Kazui, Y. Yasui, K. Saiin, S. Naito, S. Takenaka, Y. Mizuguchi, A. Tada, Y. Kobayashi, K. Omote, T. Sato, K. Kamiya, T. Nagai, S. Tanaka, T. Anzai, Cardiology Journal, 2022, 29, 718-719
    DOI: 10.5603/cj.2022.0063
  • Virological Characteristics of the SARS-CoV-2 Omicron BA.2 Spike
    D. Yamasoba, I. Kimura, H. Nasser, Y. Morioka, N. Nao, J. Ito, K. Uriu, M. Tsuda, J. Zahradnik, K. Shirakawa, R. Suzuki, M. Kishimoto, Y. Kosugi, K. Kobiyama, T. Hara, M. Toyoda, Y. L. Tanaka, E. P. Butlertanaka, R. Shimizu, H. Ito, L. Wang, Y. Oda, Y. Orba, M. Sasaki, K. Nagata, K. Yoshimatsu, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, J. Kuramochi, M. Seki, R. Fujiki, A. Kaneda, T. Shimada, T. Nakada, S. Sakao, T. Suzuki, T. Ueno, A. Takaori-Kondo, K. J. Ishii, G. Schreiber, H. Sawa, A. Saito, T. Irie, S. Tanaka, K. Matsuno, T. Fukuhara, T. Ikeda, K. Sato, Cell, 2022, 185, 2103-+
    DOI: 10.1016/j.cell.2022.04.035
  • Luseogliflozin Preserves the Pancreatic Beta-Cell Mass and Function in Db/db Mice by Improving Mitochondrial Function
    Y. Yamauchi, A. Nakamura, T. Yokota, K. Takahashi, S. Kawata, K. Tsuchida, K. Omori, H. Nomoto, H. Kameda, K. Y. Cho, T. Anzai, S. Tanaka, Y. Terauchi, H. Miyoshi, T. Atsumi, Scientific Reports, 2022, 12,
    DOI: 10.1038/s41598-022-13888-6
  • Protocol for a Sepsis Model Utilizing Fecal Suspension in Mice: Fecal Suspension Intraperitoneal Injection Model
    T. Tsuchida, T. Wada, A. Mizugaki, Y. Oda, K. Kayano, K. Yamakawa, S. Tanaka, Frontiers in Medicine, 2022, 9,
    DOI: 10.3389/fmed.2022.765805
  • Clinical and Radiological Findings of Glioblastomas Harboring a BRAF V600E Mutation
    Y. Ishi, S. Yamaguchi, M. Okamoto, R. Sawaya, S. Endo, H. Motegi, S. Terasaka, Z. Tanei, K. C. Hatanaka, S. Tanaka, M. Fujimura, Brain Tumor Pathology, 2022, 39, 162-170
    DOI: 10.1007/s10014-022-00432-7
  • Novel Hydrogel X Induces Cancer Stemness by Involving in Epigenetic Regulation
    J. Suzuka, M. Tsuda, L. Wang, K. Kumegawa, R. Maruyama, S. Tanaka, Cancer Sci., 2022, 113, 747-747
  • Double Network Hydrogel as Novel Microenvironment Enhances Osteopontin and Reprogramming of Cancer Stem Cells
    S. Tanaka, J. Suzuka, L. Wang, M. Tsuda, Cancer Sci., 2022, 113, 746-746
  • Aberrant Expression of MYD88 via RNA-Controlling CNOT4 and EXOSC3 in Normal Mucosa Influences Onset of Colonic Cancer
    M. Tsuda, L. Wang, S. Hirano, M. Asaka, S. Tanaka, Cancer Sci., 2022, 113,
  • Attenuated Fusogenicity and Pathogenicity of SARS-CoV-2 Omicron Variant
    R. Suzuki, D. Yamasoba, I. Kimura, L. Wang, M. Kishimoto, J. Ito, Y. Morioka, N. Nao, H. Nasser, K. Uriu, Y. Kosugi, M. Tsuda, Y. Orba, M. Sasaki, R. Shimizu, R. Kawabata, K. Yoshimatsu, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, H. Sawa, T. Ikeda, T. Irie, K. Matsuno, S. Tanaka, T. Fukuhara, K. Sato, G. P. J. Genotype Phenotype Japan, Nature, 2022, 603, 700-+
    DOI: 10.1038/s41586-022-04462-1
  • Novel Rapid Immunohistochemistry Using an Alternating Current Electric Field Identifies Rac and Cdc42 Activation in Human Colon Cancer FFPE Tissues
    M. Tsuda, R. Horio, L. Wang, T. Takenami, J. Moriya, J. Suzuka, H. Sugino, Z. Tanei, M. Tanino, S. Tanaka, Scientific Reports, 2022, 12,
    DOI: 10.1038/s41598-022-05892-7


  • Enhanced Fusogenicity and Pathogenicity of SARS-CoV-2 Delta P681R Mutation
    A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Q. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, S. Loeber, M. Tsuda, L. Wang, S. Ozono, E. P. Butlertanaka, Y. L. Tanaka, R. Shimizu, K. Shimizu, K. Yoshimatsu, R. Kawabata, T. Sakaguchi, K. Tokunaga, I. Yoshida, H. Asakura, M. Nagashima, Y. Kazuma, R. Nomura, Y. Horisawa, K. Yoshimura, A. Takaori-Kondo, M. Imai, S. Tanaka, S. Nakagawa, T. Ikeda, T. Fukuhara, Y. Kawaoka, K. Sato, G. P. J. Genotype Phenotype Japan, Nature, 2021, 602, 300-+
    DOI: 10.1038/s41586-021-04266-9
  • Loss of FAM83H Promotes Cell Migration and Invasion in Cutaneous Squamous Cell Carcinoma via Impaired Keratin Distribution
    K. Tokuchi, S. Kitamura, T. Maeda, M. Watanabe, S. Hatakeyama, S. Kano, S. Tanaka, H. Ujiie, T. Yanagi, Journal of Dermatological Science, 2021, 104, 112-121
    DOI: 10.1016/j.jdermsci.2021.09.007
  • Hydroxyapatite-Hybridized Double-Network Hydrogel Surface Enhances Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells to Osteogenic Cells
    T. Kaibara, L. Wang, M. Tsuda, T. Nonoyama, T. Kurokawa, N. Iwasaki, J. P. Gong, S. Tanaka, K. Yasuda, Journal of Biomedical Materials Research Part A, 2021, 110, 747-760
    DOI: 10.1002/jbm.a.37324
  • Aberrant Expression of MYD88 via RNA-Controlling CNOT4 and EXOSC3 in Colonic Mucosa Impacts Generation of Colonic Cancer
    M. Tsuda, M. Noguchi, T. Kurai, Y. Ichihashi, K. Ise, L. Wang, Y. Ishida, M. Tanino, S. Hirano, M. Asaka, S. Tanaka, Cancer Sci., 2021, 112, 5100-5113
    DOI: 10.1111/cas.15157
  • Fast in Vivo Fixation of Double Network Hydrogel to Bone by Monetite Surface Hybridization
    T. Nonoyama, L. Wang, R. Kiyama, N. Kashimura, K. Yasuda, S. Tanaka, T. Kurokawa, J. P. Gong, Journal of the Ceramic Society of Japan, 2021, 129, 584-589
    DOI: 10.2109/jcersj2.21084
  • Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
    G. Parajuli, M. Tekguc, J. B. Wing, A. Hashimoto, D. Okuzaki, T. Hirata, A. Sasaki, T. Itokazu, H. Handa, H. Sugino, Y. Nishikawa, H. Metwally, Y. Kodama, S. Tanaka, H. Sabe, T. Yamashita, S. Sakaguchi, T. Kishimoto, S. Hashimoto, Cancer Immunology Research, 2021, 9, 862-876
    DOI: 10.1158/2326-6066.cir-21-0014
  • The CD44/COL17A1 Pathway Promotes the Formation of Multilayered, Transformed Epithelia
    K. Kozawa, M. Sekai, K. Ohba, S. Ito, H. Sako, T. Maruyama, M. Kakeno, T. Shirai, K. Kuromiya, T. Kamasaki, K. Kohashi, S. Tanaka, S. Ishikawa, N. Sato, S. Asano, H. Suzuki, N. Tanimura, Y. Mukai, N. Gotoh, M. Tanino, K. Natsuga, T. Soga, T. Nakamura, Y. Yabuta, M. Saitou, T. Ito, K. Matsuura, M. Tsunoda, T. Kikumori, T. Iida, Y. Mizutani, Y. Miyai, K. Kaibuchi, A. Enomoto, Y. Fujita, Current Biology, 2021, 31, 3086-+
    DOI: 10.1016/j.cub.2021.04.078
  • Difference in the Malignancy between RAS and GLI1-Transformed Astrocytes Is Associated with Frequency of p27(KIP1)-Positive Cells in Xenograft Tissues
    K. Sasai, K. Tabu, T. Saito, Y. Matsuba, T. C. Saido, S. Tanaka, Pathology Research and Practice, 2021, 223,
    DOI: 10.1016/j.prp.2021.153465
  • Comprehensive Molecular Profiling of Pulmonary Pleomorphic Carcinoma
    M. Nagano, S. Kohsaka, T. Hayashi, T. Ueno, S. Kojima, A. Shinozaki-Ushiku, S. Morita, M. Tsuda, S. Tanaka, T. Shinohara, Y. Omori, F. Sugaya, H. Kato, Y. Narita, J. Nakajima, K. Suzuki, K. Takamochi, H. Mano, Npj Precision Oncology, 2021, 5,
    DOI: 10.1038/s41698-021-00201-3
  • Loss of H3K27 Trimethylation Is Frequent in IDH1-R132H but Not in Non-Canonical IDH1/2 Mutated and 1p/19q Codeleted Oligodendroglioma: A Japanese Cohort Study
    U. Habiba, H. Sugino, R. Yordanova, K. Ise, Z. Tanei, Y. Ishida, S. Tanikawa, S. Terasaka, K. Sato, Y. Kamoshima, M. Katoh, M. Nagane, J. Shibahara, M. Tsuda, S. Tanaka, Acta Neuropathologica Communications, 2021, 9,
    DOI: 10.1186/s40478-021-01194-7
  • High-Grade Neuroepithelial Tumor with BCL6 Corepressor-Alteration Presenting Pathological and Radiological Calcification: A Case Report
    Y. Ishi, A. Shimizu, E. Takakuwa, M. Sugiyama, M. Okamoto, H. Motegi, S. Hirabayashi, Y. Cho, A. Iguchi, A. Manabe, S. Nobusawa, S. Tanaka, S. Yamaguchi, Pathology International, 2021, 71, 348-354
    DOI: 10.1111/pin.13083
  • Severe Infection Including Disseminated Herpes Zoster Triggered by Subclinical Cushing's Disease: A Case Report
    Y. Yamauchi, H. Kameda, K. Omori, M. Tani, K. Y. Cho, A. Nakamura, H. Miyoshi, S. Tanaka, T. Atsumi, Bmc Endocrine Disorders, 2021, 21, 6
    DOI: 10.1186/s12902-021-00757-y
  • Involvement of BMP and Wnt Signals Leading to Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification
    N. Katono, M. Tsuda, J. Suzuka, Y. Oda, L. Wang, Z. Tanei, M. Tanino, T. Ohata, E. Nagabuchi, Y. Ishida, S. Kimura, T. Iwanaga, S. Tanaka, Annals of Clinical and Laboratory Science, 2021, 51, 271-276
  • Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    J. Suzuka, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
    DOI: 10.1038/s41551-021-00692-2
  • Ependymoma-like Tumor with Mesenchymal Differentiation Harboring C11orf95-NCOA1/2 or -RELA Fusion: A Hitherto Unclassified Tumor Related to Ependymoma
    R. Tomomasa, Y. Arai, R. Kawabata-Iwakawa, K. Fukuoka, Y. Nakano, N. Hama, S. Nakata, N. Suzuki, Y. Ishi, S. Tanaka, J. A. Takahashi, Y. Yuba, M. Shiota, A. Natsume, M. Kurimoto, Y. Shiba, M. Aoki, K. Nabeshima, T. Enomoto, T. Inoue, J. Fujimura, A. Kondo, T. Yao, N. Okura, T. Hirose, A. Sasaki, M. Nishiyama, K. Ichimura, T. Shibata, J. Hirato, H. Yokoo, S. Nobusawa, Brain Pathology, 2021, , 14
    DOI: 10.1111/bpa.12943
  • Lewy Pathology of the Esophagus Correlates with the Progression of Lewy Body Disease: A Japanese Cohort Study of Autopsy Cases
    Z. Tanei, Y. Saito, S. Ito, T. Matsubara, A. Motoda, M. Yamazaki, Y. Sakashita, I. Kawakami, M. Ikemura, S. Tanaka, R. Sengoku, T. Arai, S. Murayama, Acta Neuropathologica, 2021, 141, 25-37
    DOI: 10.1007/s00401-020-02233-8


  • Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target
    T. Kushibiki, T. Nakamura, M. Tsuda, T. Tsuchikawa, K. Hontani, K. Inoko, M. Takahashi, T. Asano, K. Okamura, S. Murakami, Y. Kurashima, Y. Ebihara, T. Noji, Y. Nakanishi, K. Tanaka, N. Maishi, K. Sasaki, WR. Park, T. Shichinohe, K. Hida, S. Tanaka, S. Hirano, Mol. Cancer Ther., 2020, 19, 187-198
    DOI: 10.1158/1535-7163.MCT-19-0491
  • Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone
    T. Nonoyama, L. Wang, M. Tsuda, Y. Suzuki, R. Kiyama, K. Yasuda, S. Tanaka, K. Nagata, R. Fujita, N. Sakamoto, N. Kawasaki, H. Yurimoto, J. P. Gong, Advanced Healthcare Materials, 2020, ,
    DOI: 10.1002/adhm.202001731
  • Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
    J. C. Huang, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
    DOI: 10.1021/acs.biomac.0c01033
  • Integrin Alpha 4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiation
    D. Hashimoto, S. Semba, M. Tsuda, T. Kurokawa, N. Kitamura, K. Yasuda, J. P. Gong, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 528, 120-126
    DOI: 10.1016/j.bbrc.2020.05.071
  • Synthetic Poly(2-Acrylamido-2-Methylpropanesulfonic Acid) Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
    S. Semba, N. Kitamura, M. Tsuda, K. Goto, S. Kurono, Y. Ohmiya, T. Kurokawa, J. P. Gong, K. Yasuda, S. Tanaka, Journal of Biomedical Materials Research Part A, 2020, ,
    DOI: 10.1002/jbm.a.37028
  • Chiral Monolayers with Achiral Tetrapod Molecules on Highly Oriented Pyrolytic Graphite
    H. Asakawa, S. Matsui, Q. T. Trinh, H. Hirao, Y. Inokuma, T. Ogoshi, S. Tanaka, K. Komatsu, A. Ohta, T. Asakawa, T. Fukuma, J. Phys. Chem. C, 2020, 124, 7760-7767
    DOI: 10.1021/acs.jpcc.9b11246
  • Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus
    U. Habiba, E. Hossain, A. Yanagawa-Matsuda, A. Chowdhury, M. Tsuda, A. U. Zaman, S. Tanaka, F. Higashino, Cancers, 2020, 12, 14
    DOI: 10.3390/cancers12040809
  • Signaling Adaptor Protein Crk Is Involved in Malignant Feature of Pancreatic Cancer Associated with Phosphorylation of c-Met
    S. Uemura, L. Wang, M. Tsuda, J. Suzuka, S. Tanikawa, H. Sugino, T. Nakamura, T. Mitsuhashi, S. Hirano, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 524, 378-384
    DOI: 10.1016/j.bbrc.2020.01.105


  • Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
    M. Frauenlob, DR. King, HL. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, JP. Gong, Macromolecules, 2019, 52, 6704-6713
    DOI: 10.1021/acs.macromol.9b01399
  • Autopsy Findings in the Early Stage of Amyotrophic Lateral Sclerosis with "Dropped Head" Syndrome
    S. Tanikawa, M. Tanino, L. Wang, M. Ishikawa, M. Miyazaki, M. Tsuda, Y. Orba, H. Sawa, K. Matoba, N. Nakamura, K. Nagashima, WW. Hall, S. Tanaka, Neuropathology, 2019, 39, 374-377
    DOI: 10.1111/neup.12583
  • Exosomes Containing ErbB2/CRK Induce Vascular Growth in Premetastatic Niches and Promote Metastasis of Bladder Cancer
    K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, S. Tanaka, Cancer Sci., 2019, 110, 2119-2132
    DOI: 10.1111/cas.14080


  • miR-23a Promotes Invasion of Glioblastoma via HOXD10-Regulated Glial-Mesenchymal Transition
    K. Yachi, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, S. Tanaka, Signal Transduction and Targeted Therapy, 2018, 3,
    DOI: 10.1038/s41392-018-0033-6