About the Research
Cell control by new materials, development of new generation diagnosis and therapy
The research in our laboratory aims at utilizing hydrogels as biomaterials to control the phenotypes of cells. The hydrogels’ physical factors, such as charge and elastic modulus, depend on the nature and structure of the monomer molecules and gels with certain conditions cause cells to undergo characteristic changes. For example, cancer stem cells, the cause of cancer recurrence, are produced by special hydrogels in a matter of 24 hours, while this process takes more than 10 days with conventional culture techniques. This leads to the development of new cancer diagnostic tools and treatments. Another kind of hydrogel has been shown to control neuronal regeneration. Based on this, we aim to develop new approaches in regenerative medicine.
At ICReDD, we have a particularly strong collaboration with Dr. Jian Ping Gong, who develops the hydrogels, to develop new gels that can be applied to clinical medicine, and with the experts in information science and computational chemistry to develop new diagnostic tools and therapeutics by controlling cells with hydrogels. The results of these collaborations will create a new integrated research field we call “material genomics”.
The Researcher’s Perspective
A Japanese saying (“Ichi-go, ichi-e”) that originates from the tea ceremony emphazises that meeting a person is a once-in-a-lifetime chance and should be cherished as such. I like that saying, and so I make sure that in our lab we have many kinds of activities to foster such interactions, besides the usual scientific work. ICReDD itself is a manifestation of this idea by encouraging human encounters where new ideas will come up. ICReDD has mixed-labs and I cherish the chance of human encounters and would like to develop a new research field.
Representative Research Achievements
- Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels.
Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S, Nat Biomed Eng. 2021 Aug;5(8):914-925.
- Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.
Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M; Genotype to Phenotype Japan (G2P-Japan) Consortium, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K, Nature. 2021 Nov 25.
- Synthetic poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces chondrogenic differentiation of ATDC5 cells via a novel protein reservoir function.
Semba S, Kitamura N, Tsuda M, Goto K, Kurono S, Ohmiya Y, Kurokawa T, Gong JP, Yasuda K, Tanaka S. J Biomed Mater Res A, 2021 Mar;109(3):354-364.
- Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, and S. Tanaka, Cancer Sci, 2019, 110, 2119-2132
- miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition
K. Yachi, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, and S. Tanaka, Signal Transduct and Target Ther, 2018, 3, 33
- Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
Y. Kobashigawa, M. Sakai, M. Naito, M. Yokochi, H. Kumeta, Y. Makino, K. Ogura, S. Tanaka, and F. Inagaki, Nature Structural & Molecular Biology, 2007, 14, 503-510
- SARS-CoV-2 XBB revealed to be first variant derived from recombination of two other Omicron subvariants
- Shedding light on the evolutionary rules of SARS-CoV-2 Omicron variants
- Press Release Healing the brain: hydrogels enable neuronal tissue growth
- Mechanism for resistance to retinoid treatment in breast cancer revealed
- BA.4 and BA.5 subvariants of COVID show higher pathogenicity and higher resistance to natural and vaccine-induced immunity
- Press Release Understanding the virological characteristics of the SARS-CoV-2 Omicron BA.2 spike
- COVID Omicron variant exhibits decreased lung infection but higher transmissibility
- New method enables spatial detection of regulatory factors associated with cancer tumor invasion
- One step closer to artificial cartilage. Hydrogels show signs of triggering bone marrow stem cells to change into bone-like cells
- Mutation in COVID Delta variant associated with increased pathogenicity and fusogenicity
- Uprooting cancer: Hydrogel rapidly reverts cancer cells back to cancer stem cells