About the Research
Cell control by new materials, development of new generation diagnosis and therapy
The research in our laboratory aims at utilizing hydrogels as biomaterials to control the phenotypes of cells. The hydrogels’ physical factors, such as charge and elastic modulus, depend on the nature and structure of the monomer molecules and gels with certain conditions cause cells to undergo characteristic changes. For example, cancer stem cells, the cause of cancer recurrence, are produced by special hydrogels in a matter of 24 hours, while this process takes more than 10 days with conventional culture techniques. This leads to the development of new cancer diagnostic tools and treatments. Another kind of hydrogel has been shown to control neuronal regeneration. Based on this, we aim to develop new approaches in regenerative medicine.
At ICReDD, we have a particularly strong collaboration with Dr. Jian Ping Gong, who develops the hydrogels, to develop new gels that can be applied to clinical medicine, and with the experts in information science and computational chemistry to develop new diagnostic tools and therapeutics by controlling cells with hydrogels. The results of these collaborations will create a new integrated research field we call “material genomics”.
The Researcher’s Perspective
A Japanese saying (“Ichi-go, ichi-e”) that originates from the tea ceremony emphazises that meeting a person is a once-in-a-lifetime chance and should be cherished as such. I like that saying, and so I make sure that in our lab we have many kinds of activities to foster such interactions, besides the usual scientific work. ICReDD itself is a manifestation of this idea by encouraging human encounters where new ideas will come up. ICReDD has mixed-labs and I cherish the chance of human encounters and would like to develop a new research field.
Representative Research Achievements
- Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, and S. Tanaka, Cancer Science, 2019, 110, 2119-2132
- Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
M. Frauenlob, DR. King, H. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, and JP. Gong, Macromolecules, 2019, 52, 6704-6713
- Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features
Y. Omori, Y. Ono, M. Tanino, H. Karasaki, H. Yamaguchi, T. Furukawa, K. Enomoto, J. Ueda, A. Sumi, J. Katayama, M. Muraki, K. Taniue, K. Takahashi, Y. Ambo, T. Shinohara, H. Nishihara, J. Sasajima, H. Maguchi, Y. Mizukami, T. Okumura, and S. Tanaka, Gastroenterology, 2019, 156, 647-661
- miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition
K. Yachi, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, and S. Tanaka, Signal Transduct and Target Therapy, 2018, 3, 33
- Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 Cells, which plays a significant role in the gel-induced chondrogenic differentiation
K. Goto, T. Kimura, N. Kitamura, S. Semba, Y. Ohmiya, S. Aburatani, S. Matsukura, M. Tsuda, T. Kurokawa, JP. Gong, S. Tanaka, and K. Yasuda, Journal of Biomedical Materials Research Part A, 2015, 104A, 734-746
- Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
Y. Kobashigawa, M. Sakai, M. Naito, M. Yokochi, H. Kumeta, Y. Makino, K. Ogura, S. Tanaka, and F. Inagaki, Nature Structural & Molecular Biology, 2007, 14, 503-510