TANAKA, Shinya

thumbnail image
TANAKA, Shinya
Principal Investigator
Hokkaido University
Research Areas
Tumor Pathology, Cell control by new material(s), machine learning, and complex molecules
Related Website

tanaka atmark med.hokudai.ac.jp

TANAKA, Shinya Group
Principal Investigator
  • thumbnail image
    TANAKA, Shinya
Faculty Members
Postdoctoral Fellows
Research Collaborators

About the Research

Research Theme

Cell control by new materials, development of new generation diagnosis and therapy


Biomedical engineering, Cellular reprogramming, Molecular biology, Cancer pathology, Regenerative medicine

Research Outline

The research in our laboratory aims at utilizing hydrogels as biomaterials to control the phenotypes of cells. The hydrogels’ physical factors, such as charge and elastic modulus, depend on the nature and structure of the monomer molecules and gels with certain conditions cause cells to undergo characteristic changes. For example, cancer stem cells, the cause of cancer recurrence, are produced by special hydrogels in a matter of 24 hours, while this process takes more than 10 days with conventional culture techniques. This leads to the development of new cancer diagnostic tools and treatments. Another kind of hydrogel has been shown to control neuronal regeneration. Based on this, we aim to develop new approaches in regenerative medicine.

At ICReDD, we have a particularly strong collaboration with Dr. Jian Ping Gong, who develops the hydrogels, to develop new gels that can be applied to clinical medicine, and with the experts in information science and computational chemistry to develop new diagnostic tools and therapeutics by controlling cells with hydrogels. The results of these collaborations will create a new integrated research field we call “material genomics”.

The Researcher’s Perspective

A Japanese saying (“Ichi-go, ichi-e”) that originates from the tea ceremony emphazises that meeting a person is a once-in-a-lifetime chance and should be cherished as such. I like that saying, and so I make sure that in our lab we have many kinds of activities to foster such interactions, besides the usual scientific work. ICReDD itself is a manifestation of this idea by encouraging human encounters where new ideas will come up. ICReDD has mixed-labs and I cherish the chance of human encounters and would like to develop a new research field.

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Representative Research Achievements

  • Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
    K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, and S. Tanaka, Cancer Science, 2019, 110, 2119-2132
    DOI: 10.1111/cas.14080
  • Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
    M. Frauenlob, DR. King, H. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, and JP. Gong, Macromolecules, 2019, 52, 6704-6713
    DOI: 10.1021/acs.macromol.9b01399
  • Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features
    Y. Omori, Y. Ono, M. Tanino, H. Karasaki, H. Yamaguchi, T. Furukawa, K. Enomoto, J. Ueda, A. Sumi, J. Katayama, M. Muraki, K. Taniue, K. Takahashi, Y. Ambo, T. Shinohara, H. Nishihara, J. Sasajima, H. Maguchi, Y. Mizukami, T. Okumura, and S. Tanaka, Gastroenterology, 2019, 156, 647-661
    DOI: 10.1053/j.gastro.2018.10.029
  • miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition
    K. Yachi, M. Tsuda, S. Kohsaka, L. Wang
    , Y. Oda, S. Tanikawa, Y. Ohba, and S. Tanaka, Signal Transduct and Target Therapy, 2018, 3, 33
    DOI: 10.1038/s41392-018-0033-6
  • Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 Cells, which plays a significant role in the gel-induced chondrogenic differentiation
    K. Goto, T. Kimura, N. Kitamura, S. Semba, Y. Ohmiya, S. Aburatani, S. Matsukura, M. Tsuda, T. Kurokawa, JP. Gong, S. Tanaka, and K. Yasuda, Journal of Biomedical Materials Research Part A2015, 104A, 734-746
    DOI: 0.1002/jbm.a.35615
  • Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
    Y. Kobashigawa, M. Sakai, M. Naito, M. Yokochi, H. Kumeta, Y. Makino, K. Ogura, S. Tanaka, and F. Inagaki, Nature Structural & Molecular Biology, 2007, 14, 503-510
    DOI: 10.1038/nsmb1241

Related Research



  • Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
    G. Parajuli, M. Tekguc, J. B. Wing, A. Hashimoto, D. Okuzaki, T. Hirata, A. Sasaki, T. Itokazu, H. Handa, H. Sugino, Y. Nishikawa, H. Metwally, Y. Kodama, S. Tanaka, H. Sabe, T. Yamashita, S. Sakaguchi, T. Kishimoto, S. Hashimoto, Cancer Immunology Research, 2021, 9, 862-876
    DOI: 10.1158/2326-6066.cir-21-0014
  • The CD44/COL17A1 Pathway Promotes the Formation of Multilayered, Transformed Epithelia
    K. Kozawa, M. Sekai, K. Ohba, S. Ito, H. Sako, T. Maruyama, M. Kakeno, T. Shirai, K. Kuromiya, T. Kamasaki, K. Kohashi, S. Tanaka, S. Ishikawa, N. Sato, S. Asano, H. Suzuki, N. Tanimura, Y. Mukai, N. Gotoh, M. Tanino, K. Natsuga, T. Soga, T. Nakamura, Y. Yabuta, M. Saitou, T. Ito, K. Matsuura, M. Tsunoda, T. Kikumori, T. Iida, Y. Mizutani, Y. Miyai, K. Kaibuchi, A. Enomoto, Y. Fujita, Current Biology, 2021, 31, 3086-+
    DOI: 10.1016/j.cub.2021.04.078
  • Difference in the Malignancy between RAS and GLI1-Transformed Astrocytes Is Associated with Frequency of p27(KIP1)-Positive Cells in Xenograft Tissues
    K. Sasai, K. Tabu, T. Saito, Y. Matsuba, T. C. Saido, S. Tanaka, Pathology Research and Practice, 2021, 223,
    DOI: 10.1016/j.prp.2021.153465
  • Comprehensive Molecular Profiling of Pulmonary Pleomorphic Carcinoma
    M. Nagano, S. Kohsaka, T. Hayashi, T. Ueno, S. Kojima, A. Shinozaki-Ushiku, S. Morita, M. Tsuda, S. Tanaka, T. Shinohara, Y. Omori, F. Sugaya, H. Kato, Y. Narita, J. Nakajima, K. Suzuki, K. Takamochi, H. Mano, Npj Precision Oncology, 2021, 5,
    DOI: 10.1038/s41698-021-00201-3
  • Loss of H3K27 Trimethylation Is Frequent in IDH1-R132H but Not in Non-Canonical IDH1/2 Mutated and 1p/19q Codeleted Oligodendroglioma: A Japanese Cohort Study
    U. Habiba, H. Sugino, R. Yordanova, K. Ise, Z. Tanei, Y. Ishida, S. Tanikawa, S. Terasaka, K. Sato, Y. Kamoshima, M. Katoh, M. Nagane, J. Shibahara, M. Tsuda, S. Tanaka, Acta Neuropathologica Communications, 2021, 9,
    DOI: 10.1186/s40478-021-01194-7
  • High-Grade Neuroepithelial Tumor with BCL6 Corepressor-Alteration Presenting Pathological and Radiological Calcification: A Case Report
    Y. Ishi, A. Shimizu, E. Takakuwa, M. Sugiyama, M. Okamoto, H. Motegi, S. Hirabayashi, Y. Cho, A. Iguchi, A. Manabe, S. Nobusawa, S. Tanaka, S. Yamaguchi, Pathology International, 2021, 71, 348-354
    DOI: 10.1111/pin.13083
  • Severe Infection Including Disseminated Herpes Zoster Triggered by Subclinical Cushing's Disease: A Case Report
    Y. Yamauchi, H. Kameda, K. Omori, M. Tani, K. Y. Cho, A. Nakamura, H. Miyoshi, S. Tanaka, T. Atsumi, Bmc Endocrine Disorders, 2021, 21, 6
    DOI: 10.1186/s12902-021-00757-y
  • Involvement of BMP and Wnt Signals Leading to Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification
    N. Katono, M. Tsuda, J. Suzuka, Y. Oda, L. Wang, Z. Tanei, M. Tanino, T. Ohata, E. Nagabuchi, Y. Ishida, S. Kimura, T. Iwanaga, S. Tanaka, Annals of Clinical and Laboratory Science, 2021, 51, 271-276
  • Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    J. Suzuka, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
    DOI: 10.1038/s41551-021-00692-2
  • Ependymoma-like Tumor with Mesenchymal Differentiation Harboring C11orf95-NCOA1/2 or -RELA Fusion: A Hitherto Unclassified Tumor Related to Ependymoma
    R. Tomomasa, Y. Arai, R. Kawabata-Iwakawa, K. Fukuoka, Y. Nakano, N. Hama, S. Nakata, N. Suzuki, Y. Ishi, S. Tanaka, J. A. Takahashi, Y. Yuba, M. Shiota, A. Natsume, M. Kurimoto, Y. Shiba, M. Aoki, K. Nabeshima, T. Enomoto, T. Inoue, J. Fujimura, A. Kondo, T. Yao, N. Okura, T. Hirose, A. Sasaki, M. Nishiyama, K. Ichimura, T. Shibata, J. Hirato, H. Yokoo, S. Nobusawa, Brain Pathology, 2021, , 14
    DOI: 10.1111/bpa.12943
  • Lewy Pathology of the Esophagus Correlates with the Progression of Lewy Body Disease: A Japanese Cohort Study of Autopsy Cases
    Z. Tanei, Y. Saito, S. Ito, T. Matsubara, A. Motoda, M. Yamazaki, Y. Sakashita, I. Kawakami, M. Ikemura, S. Tanaka, R. Sengoku, T. Arai, S. Murayama, Acta Neuropathologica, 2021, 141, 25-37
    DOI: 10.1007/s00401-020-02233-8


  • Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target
    T. Kushibiki, T. Nakamura, M. Tsuda, T. Tsuchikawa, K. Hontani, K. Inoko, M. Takahashi, T. Asano, K. Okamura, S. Murakami, Y. Kurashima, Y. Ebihara, T. Noji, Y. Nakanishi, K. Tanaka, N. Maishi, K. Sasaki, WR. Park, T. Shichinohe, K. Hida, S. Tanaka, S. Hirano, Mol. Cancer Ther., 2020, 19, 187-198
    DOI: 10.1158/1535-7163.MCT-19-0491
  • Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone
    T. Nonoyama, L. Wang, M. Tsuda, Y. Suzuki, R. Kiyama, K. Yasuda, S. Tanaka, K. Nagata, R. Fujita, N. Sakamoto, N. Kawasaki, H. Yurimoto, J. P. Gong, Advanced Healthcare Materials, 2020, ,
    DOI: 10.1002/adhm.202001731
  • Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
    J. C. Huang, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
    DOI: 10.1021/acs.biomac.0c01033
  • Integrin Alpha 4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiation
    D. Hashimoto, S. Semba, M. Tsuda, T. Kurokawa, N. Kitamura, K. Yasuda, J. P. Gong, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 528, 120-126
    DOI: 10.1016/j.bbrc.2020.05.071
  • Synthetic Poly(2-Acrylamido-2-Methylpropanesulfonic Acid) Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
    S. Semba, N. Kitamura, M. Tsuda, K. Goto, S. Kurono, Y. Ohmiya, T. Kurokawa, J. P. Gong, K. Yasuda, S. Tanaka, Journal of Biomedical Materials Research Part A, 2020, ,
    DOI: 10.1002/jbm.a.37028
  • Chiral Monolayers with Achiral Tetrapod Molecules on Highly Oriented Pyrolytic Graphite
    H. Asakawa, S. Matsui, Q. T. Trinh, H. Hirao, Y. Inokuma, T. Ogoshi, S. Tanaka, K. Komatsu, A. Ohta, T. Asakawa, T. Fukuma, J. Phys. Chem. C, 2020, 124, 7760-7767
    DOI: 10.1021/acs.jpcc.9b11246
  • Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus
    U. Habiba, E. Hossain, A. Yanagawa-Matsuda, A. Chowdhury, M. Tsuda, A. U. Zaman, S. Tanaka, F. Higashino, Cancers, 2020, 12, 14
    DOI: 10.3390/cancers12040809
  • Signaling Adaptor Protein Crk Is Involved in Malignant Feature of Pancreatic Cancer Associated with Phosphorylation of c-Met
    S. Uemura, L. Wang, M. Tsuda, J. Suzuka, S. Tanikawa, H. Sugino, T. Nakamura, T. Mitsuhashi, S. Hirano, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 524, 378-384
    DOI: 10.1016/j.bbrc.2020.01.105


  • Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
    M. Frauenlob, DR. King, HL. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, JP. Gong, Macromolecules, 2019, 52, 6704-6713
    DOI: 10.1021/acs.macromol.9b01399
  • Autopsy Findings in the Early Stage of Amyotrophic Lateral Sclerosis with "Dropped Head" Syndrome
    S. Tanikawa, M. Tanino, L. Wang, M. Ishikawa, M. Miyazaki, M. Tsuda, Y. Orba, H. Sawa, K. Matoba, N. Nakamura, K. Nagashima, WW. Hall, S. Tanaka, Neuropathology, 2019, 39, 374-377
    DOI: 10.1111/neup.12583
  • Exosomes Containing ErbB2/CRK Induce Vascular Growth in Premetastatic Niches and Promote Metastasis of Bladder Cancer
    K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, S. Tanaka, Cancer Sci., 2019, 110, 2119-2132
    DOI: 10.1111/cas.14080


  • miR-23a Promotes Invasion of Glioblastoma via HOXD10-Regulated Glial-Mesenchymal Transition
    K. Yachi, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, S. Tanaka, Signal Transduction and Targeted Therapy, 2018, 3,
    DOI: 10.1038/s41392-018-0033-6