研究紹介
研究テーマ
バイオマテリアルによる新しい細胞制御法と次世代診断治療法の開発
キーワード
研究概要
私たちの研究室では、バイオマテリアルとしてハイドロゲルを用いて、細胞を制御する研究に取り組んでいます。ハイドロゲルは、モノマー分子の性質や構造により荷電や弾性率など様々な物理因子を持ちます。ある種のゲルは細胞に特徴的な変化を誘導します。例えば、がんの再発の原因の「がん幹細胞」は見つけ出すのに10日以上の長時間を要しますが、特殊なハイドロゲルは極めて短時間で、がん幹細胞を創り出します。このことは新しいがんの診断法や治療法の開発に繋がります。またある種のゲルは神経再生を制御することがわかってきてました。再生医療への応用が期待されます。
私達はICReDDの中で、ハイドロゲル研究の世界の第一人者のグン・チェンピン先生と協力して、新しい細胞生物学の世界を創り出します。また、情報科学、計算科学の先生方と協力して、新しい診断、治療法の開発を目指します。一連の共同研究の成果は「マテリアルゲノミクス」という新しい融合研究分野を生み出します。
研究者の思い
茶道に由来する「一期一会」という言葉は、人との出会いは一生に一度のチャンスであり、だからこそ大切にするべきだと教えてくれます。 私はこの言葉が好きで、研究室では日常の研究に加えて様々な行事を企画して、ラボメンバー間の交流を深めるようにしています。ICReDDでは、メンバーが自由に集まれる部屋があり、様々な交流がなされます。ミックスラボもあります。人との出会い、そこに融合研究が芽生えます。一期一会の考えを大事にして、芽生えた研究を大きく発展させたいと思います。
MANABIYAコースの研修内容はこちらです。MANABIYA全般について詳しく知りたい方は、こちらをクリックしてください。
代表的な研究成果
- Exosomes containing ErbB2/CRK induce vascular growth in premetastatic niches and promote metastasis of bladder cancer
K. Yoshida, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, and S. Tanaka, Cancer Science, 2019, 110, 2119-2132
DOI: 10.1111/cas.14080 - Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
M. Frauenlob, DR. King, H. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, and JP. Gong, Macromolecules, 2019, 52, 6704-6713
DOI: 10.1021/acs.macromol.9b01399 - Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features
Y. Omori, Y. Ono, M. Tanino, H. Karasaki, H. Yamaguchi, T. Furukawa, K. Enomoto, J. Ueda, A. Sumi, J. Katayama, M. Muraki, K. Taniue, K. Takahashi, Y. Ambo, T. Shinohara, H. Nishihara, J. Sasajima, H. Maguchi, Y. Mizukami, T. Okumura, and S. Tanaka, Gastroenterology, 2019, 156, 647-661
DOI: 10.1053/j.gastro.2018.10.029 - miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition
K. Yachi, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, and S. Tanaka, Signal Transduct and Target Therapy, 2018, 3, 33
DOI: 10.1038/s41392-018-0033-6 - Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 Cells, which plays a significant role in the gel-induced chondrogenic differentiation
K. Goto, T. Kimura, N. Kitamura, S. Semba, Y. Ohmiya, S. Aburatani, S. Matsukura, M. Tsuda, T. Kurokawa, JP. Gong, S. Tanaka, and K. Yasuda, Journal of Biomedical Materials Research Part A, 2015, 104A, 734-746
DOI: 0.1002/jbm.a.35615 - Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK
Y. Kobashigawa, M. Sakai, M. Naito, M. Yokochi, H. Kumeta, Y. Makino, K. Ogura, S. Tanaka, and F. Inagaki, Nature Structural & Molecular Biology, 2007, 14, 503-510
DOI: 10.1038/nsmb1241
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- プレスリリース 新規開発したゲルを用いて脳の神経組織の再構築に成功~将来の脳損傷の新治療法開発への貢献に期待~
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業績一覧
2024年
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Virological Characteristics of a SARS-CoV-2-Related Bat Coronavirus, BANAL-20-236
, A. Plianchaisuk, S. Deguchi, H. Ito, N. Nao, L. Wang, H. Nasser, T. Tamura, I. Kimura, Y. Kashima, R. Suzuki, S. Suzuki, I. Kida, M. Tsuda, Y. Oda, R. Hashimoto, Y. Watanabe, K. Uriu, D. Yamasoba, Z. Guo, A. Jr, Y. Kosugi, L. Chen, L. Pan, Y. Kaku, H. Chu, F. Donati, S. Temmam, M. Eloit, Y. Yamamoto, T. Nagamoto, H. Asakura, K. Sadamasu, K. Yoshimura, Y. Suzuki, J. Ito, T. Ikeda, M. Nagashima, S. Tanaka, K. Matsuno, T. Fukuhara, K. Takayama, K. Sato, EBIOMEDICINE, 2024, 104,
DOI: 10.1016/j.ebiom.2024.105181
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Involvement of SARS-CoV-2 Accessory Proteins in Immunopathogenesis
, T. Tamura, L. Wang, K. Mori, M. Tsuda, R. Suzuki, S. Suzuki, K. Yoshimatsu, S. Tanaka, T. Fukuhara, MICROBIOLOGY AND IMMUNOLOGY, 2024, ,
DOI: 10.1111/1348-0421.13157
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Virological Characteristics of the SARS-CoV-2 Omicron EG.5.1 Variant
, S. Deguchi, T. Nomai, M. Padilla-Blanco, A. Plianchaisuk, L. Wang, M. Begum, K. Uriu, K. Mizuma, N. Nao, I. Kojima, T. Tsubo, J. Li, Y. Matsumura, M. Nagao, Y. Oda, M. Tsuda, Y. Anraku, S. Kita, H. Yajima, K. Sasaki-Tabata, Z. Guo, A. Hinay, K. Yoshimatsu, Y. Yamamoto, T. Nagamoto, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, H. Nasser, M. Jonathan, O. Putri, Y. Kim, L. Chen, R. Suzuki, T. Tamura, K. Maenaka, T. Irie, K. Matsuno, S. Tanaka, J. Ito, T. Ikeda, K. Takayama, J. Zahradnik, T. Hashiguchi, T. Fukuhara, K. Sato, G. P. J. G. Consortium, MICROBIOLOGY AND IMMUNOLOGY, 2024, ,
DOI: 10.1111/1348-0421.13165
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Sporadic Gastric Foveolar-Type Adenoma with Morular Metaplasia
, Z. Tanei, Y. Ishikawa, T. Kimura, Y. Ishida, S. Tanaka, Pathology International, 2024, ,
DOI: 10.1111/pin.13462
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Akaluc Bioluminescence Offers Superior Sensitivity to Track in Vivo Dynamics of SARS-CoV-2 Infection
, H. Ito, S. Torii, L. Wang, R. Suzuki, S. Tsujino, A. Kamiyama, Y. Oda, M. Tsuda, Y. Morioka, S. Suzuki, K. Shirakawa, K. Sato, K. Yoshimatsu, Y. Matsuura, S. Iwano, S. Tanaka, T. Fukuhara, Iscience, 2024, 27(5),
DOI: 10.1016/j.isci.2024.109647
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Acute Eosinophilic Myocarditis Mimicking Inferior Myocardial Infarction Presenting with Delayed Hypereosinophilia
, N. Funayama, D. Hotta, S. Tanaka, Cardiology Journal, 2024, 31(2), 361-362
DOI: 10.5603/cj.96133
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Virological Characteristics of the SARS-CoV-2 Omicron XBB.1.5 Variant
, T. Irie, S. Deguchi, H. Yajima, M. Tsuda, H. Nasser, K. Mizuma, A. Plianchaisuk, S. Suzuki, K. Uriu, M. M. Begum, R. Shimizu, M. Jonathan, R. Suzuki, T. Kondo, H. Ito, A. Kamiyama, K. Yoshimatsu, M. Shofa, R. Hashimoto, Y. Anraku, K. T. Kimura, S. Kita, J. Sasaki, K. Sasaki-Tabata, K. Maenaka, N. Nao, L. Wang, Y. Oda, H. Sawa, R. Kawabata, Y. Watanabe, A. Sakamoto, N. Yasuhara, T. Suzuki, Y. Nakajima, Z. Ferdous, K. Shishido, Y. Mugita, O. Takahashi, K. Ichihara, Y. Kaku, N. Misawa, Z. Y. Guo, A. Hinay, Y. Kosugi, S. Fujita, J. M. Tolentino, L. Chen, L. Pan, M. Suganami, M. Chiba, R. Yoshimura, K. Yasuda, K. Iida, N. Ohsumi, A. P. Strange, Y. Shibatani, T. Nishiuchi, S. Tanaka, O. Putri, G. Joas, Y. Kim, D. Yamasoba, K. Yoshimura, K. Sadamasu, M. Nagashima, H. Asakura, I. Yoshida, S. Nakagawa, A. Takaori-Kondo, K. Shirakawa, K. Nagata, R. Nomura, Y. Horisawa, Y. Tashiro, Y. Kawai, T. Ueno, C. Motozono, M. Toyoda, T. Ikeda, A. Saito, K. Matsuno, J. Ito, K. Sato, T. Hashiguchi, K. Takayama, T. Fukuhara, G. P. Genotype Phenotype Japan, Nat. Commun., 2024, 15,
DOI: 10.1038/s41467-024-45274-3
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Targeted Demethylation and Activation of NLRC5 Augment Cancer Immunogenicity through MHC Class I
, T. Watanabe, Y. Oda, W. D. Shen, A. Ahmad, R. Ouda, P. de Figueiredo, H. Kitamura, S. Tanaka, K. S. Kobayashi, Proceedings of the National Academy of Sciences of the United States of America, 2024, 121, (6), e2310821121
DOI: 10.1073/pnas.2310821121
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Structure-Changeable Luminescent Eu(III) Complex as a Human Cancer Grade Probing System for Brain Tumor Diagnosis
, M. Kono, Y. Yamaguchi, J. Islam, S. Shoji, Y. Kitagawa, K. Fushimi, S. Watanabe, G. Matsuba, A. Yamamoto, M. Tanaka, M. Tsuda, S. Tanaka, Y. Hasegawa, Scientific Reports, 2024, 14, Article number: 778
DOI: 10.1038/s41598-023-50138-9
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A Case of Uterine Tumor Resembling Ovarian Sex Cord Tumor With Prominent Myxoid Features
, Z. Tanei, Y. Oda, S. Tanikawa, H. Sugino, Y. Ishida, M. Tsuda, Y. Gotoda, K. Nishiwaki, H. Yanai, T. Hasegawa, K. Nagashima, S. Tanaka, International Journal of Gynecological Pathology, 2024, 43, 41-46
DOI: 10.1097/pgp.0000000000000949
2023年
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Fibrinous Pericarditis Secondary to Recurrent Acute Myeloid Leukaemia
, T. Kimura, K. Minauchi, S. Tanaka, European Heart Journal-Case Reports, 2023, 7, 11
DOI: 10.1093/ehjcr/ytad537
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Multimodality Imaging Approach to an Adult Case with Cor Triatriatum Sinister
, N. Funayama, D. Hotta, S. Tanaka, Cardiology Journal, 2023, 30, 1057-1058
DOI: 10.5603/cj.96262
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Association of Coronary Plaque Morphology with Inflammatory Biomarkers and Target Lesion Revascularization in Patients with Chronic Coronary Syndrome: An Optical Coherence Tomography Study
, Konishi, T., Kazui, S., Yasui, Y., Takahashi, Y., Naito, S., Takenaka, S., Mizuguchi, Y., Tada, A., Kobayashi, Y., Kato, Y., Omote, K., Sato, T., Kamiya, K., Nagai, T., Tanaka, S., Anzai, T., American Journal of Cardiovascular Disease, 2023, 13, (5), 309-319
DOI:
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Lethal Complication: Ventricular Septal Perforation and Right Ventricular Infarction after Acute Myocardial Infarction
, N. Funayama, T. Yamamoto, D. Hotta, S. Tanaka, Clinical Case Reports, 2023, 11,
DOI: 10.1002/ccr3.7994
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Deep Vein Thrombosis Due to Left Iliac Vein Compression Syndrome Complicated by Acute Pulmonary Thromboembolism and Cerebral Infarction
, N. Funayama, D. Hotta, S. Tanaka, Acta Cardiologica, 2023, ,
DOI: 10.1080/00015385.2023.2250945
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Comparative Pathogenicity of SARS-CoV-2 Omicron Subvariants Including BA.1, BA.2, and BA.5
, D. Yamasoba, Y. Oda, J. Ito, T. Kamasaki, N. Nao, R. Hashimoto, Y. Fujioka, R. Suzuki, L. Wang, H. Ito, Y. Kashima, I. Kimura, M. Kishimoto, M. Tsuda, H. Sawa, K. Yoshimatsu, Y. Yamamoto, T. Nagamoto, J. Kanamune, Y. Suzuki, Y. Ohba, I. Yokota, K. Matsuno, K. Takayama, S. Tanaka, K. Sato, T. Fukuhara, G. P. J. Genotype Phenotype Japan, Communications Biology, 2023, 6, Article number: 772
DOI: 10.1038/s42003-023-05081-w
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Increased Piezo1 Expression in Myofibroblasts in Patients with Symptomatic Carotid Atherosclerotic Plaques Undergoing Carotid Endarterectomy: A Pilot Study
, K. Kamiyama, T. Osato, T. Yoshimoto, T. Aoki, T. Anzai, S. Tanaka, Vascular, 2023, ,
DOI: 10.1177/17085381231192380
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Convergent Evolution of SARS-CoV-2 Omicron Subvariants Leading to the Emergence of BQ.1.1 Variant
, R. Suzuki, K. Uriu, Y. Itakura, J. Zahradnik, K. T. Kimura, S. Deguchi, L. Wang, S. Lytras, T. Tamura, I. Kida, H. Nasser, M. Shofa, M. M. Begum, M. Tsuda, Y. Oda, T. Suzuki, J. Sasaki, K. Sasaki-Tabata, S. Fujita, K. Yoshimatsu, H. Ito, N. Nao, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, Y. Yamamoto, T. Nagamoto, J. Kuramochi, G. Schreiber, A. Saito, K. Matsuno, K. Takayama, T. Hashiguchi, S. Tanaka, T. Fukuhara, T. Ikeda, K. Sato, S. Suzuki, M. Kato, Z. Ferdous, H. Mouri, K. Shishido, N. Misawa, I. Kimura, Y. Kosugi, P. Lin, M. Suganami, M. Chiba, R. Yoshimura, K. Yasuda, K. Iida, N. Ohsumi, A. P. Strange, D. Sauter, S. Nakagawa, J. Q. Wu, Y. Watanabe, A. Sakamoto, N. Yasuhara, Y. Nakajima, H. Yajima, K. Shirakawa, A. Takaori-Kondo, K. Nagata, Y. Kazuma, R. Nomura, Y. Horisawa, Y. Tashiro, Y. Kawa, T. Irie, R. Kawabata, R. Shimizu, O. Takahashi, K. Ichihara, C. Motozono, M. Toyoda, T. Ueno, Y. Shibatani, T. Nishiuchi, G. P. J. Genotype Phenotype Japan, Nat. Commun., 2023, 14, 2671,
DOI: 10.1038/s41467-023-38188-z
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Virological Characteristics of the SARS-CoV-2 XBB Variant Derived from Recombination of Two Omicron Subvariants
, J. Ito, K. Uriu, J. Zahradnik, I. Kida, Y. Anraku, H. Nasser, M. Shofa, Y. Oda, S. Lytras, N. Nao, Y. Itakura, S. Deguchi, R. Suzuki, L. Wang, M. Begum, S. Kita, H. Yajima, J. Sasaki, K. Sasaki-Tabata, R. Shimizu, M. Tsuda, Y. Kosugi, S. Fujita, L. Pan, D. Sauter, K. Yoshimatsu, S. Suzuki, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, Y. Yamamoto, T. Nagamoto, G. Schreiber, K. Maenaka, T. Hashiguchi, T. Ikeda, T. Fukuhara, A. Saito, S. Tanaka, K. Matsuno, K. Takayama, K. Sato, G. P. J. Genotype Phenotype Japan, Nat. Commun., 2023, 14, 2671
DOI: 10.1038/s41467-023-38435-3
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New Onset of Hypomegakaryocytic Thrombocytopenia with the Potential for Progression to Aplastic Anemia after BNT162b2 mRNA COVID-19 Vaccination
, A. Mori, Y. Oda, E. Yokoyama, M. Kanaya, K. Izumiyama, M. Saito, S. Tanaka, M. Morioka, T. Kondo, International Journal of Hematology, 2023, ,
DOI: 10.1007/s12185-023-03618-7
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Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction
, Ebisu, Y, Sedlacík, T, Semba, S, Nonoyama, T, Kurokawa, T, Hirota, A, Takahashi, T, Yamaguchi, K, Imajo, M, Kato, H, Nishimura, T, Tanei, ZI, Tsuda, M, Nemoto, T, Gong, JP, Tanaka, S, Scientific Reports, 2023, 13, (1), Article number: 2233
DOI: 10.1038/s41598-023-28870-z
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Combination Therapy with Bevacizumab and a CCR2 Inhibitor for Human Ovarian Cancer: An in Vivo Validation Study
, T. Mitamura, L. Wang, S. I. Kubota, M. Murakami, S. Tanaka, H. Watari, Cancer Medicine, 2023, ,
DOI: 10.1002/cam4.5674
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Geometrical Analysis Identified Morphological Features of Hydrogel- Induced Cancer Stem Cells in Synovial Sarcoma Model Cells
, J. E. Clement, J. P. Gong, S. Tanaka, T. Komatsuzaki, M. Tsuda, Biochemical and Biophysical Research Communications, 2023, 642, 41-49
DOI: 10.1016/j.bbrc.2022.12.040
2022年
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ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells
, J. E. Clement, S. Tanikawa, T. Nonoyama, T. Komatsuzaki, J. P. Gong, S. Tanaka, M. Imajo, Cancers, 2022, 14,
DOI: 10.3390/cancers14235890
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Neutrophil Phenotypes Implicated in the Pathophysiology of Post-Traumatic Sepsis
, T. Wada, T. Tsuchida, Y. Oda, K. Kayano, K. Yamakawa, S. Tanaka, Frontiers in Medicine, 2022, 9,
DOI: 10.3389/fmed.2022.982399
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Germline PRDM1 Variant Rs2185379 in Long-Term Recurrence-Free Survivors of Advanced Ovarian Cancer
, T. Zhai, K. C. Hatanaka, Y. Hatanaka, T. Amano, L. Wang, S. Tanaka, H. Watari, Pharmacogenomics & Personalized Medicine, 2022, 15, 977-984
DOI: 10.2147/pgpm.s387120
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Intraoperative Rapid Immunohistochemistry with Noncontact Antibody Mixing for Undiagnosed Pulmonary Tumors
, H. Nanjo, W. Shigeeda, T. Sugai, T. Ito, Y. Maniwa, S. Takashima, H. Saito, N. Yanagawa, Y. Tanaka, T. Doi, Y. Hiroshima, K. Nomura, M. Tanino, S. Tanaka, Y. Minamiya, R. I. S. Grp, Cancer Sci., 2022, ,
DOI: 10.1111/cas.15616
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Virological Characteristics of the SARS-CoV-2 Omicron BA.2 Subvariants, Including BA.4 and BA.5
, D. Yamasoba, T. Tamura, N. Nao, T. Suzuki, Y. Oda, S. Mitoma, J. Ito, H. Nasser, J. Zahradnik, K. Uriu, S. Fujita, Y. Kosugi, L. Wang, M. Tsuda, M. Kishimoto, H. Ito, R. Suzuki, R. Shimizu, M. M. Begum, K. Yoshimatsu, K. T. Kimura, J. Sasaki, K. Sasaki-Tabata, Y. Yamamoto, T. Nagamoto, J. Kanamune, K. Kobiyama, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, K. Shirakawa, A. Takaori-Kondo, J. Kuramochi, G. Schreiber, K. J. Ishii, T. Hashiguchi, T. Ikeda, A. Saito, T. Fukuhara, S. Tanaka, K. Matsuno, K. Sato, G. P. J. Genotype Phenotype Japan, Cell, 2022, 185, 3992-4007.e16
DOI: 10.1016/j.cell.2022.09.018
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Force-Triggered Rapid Microstructure Growth on Hydrogel Surface for On-Demand Functions
, K. P. Cui, Z. J. Wang, T. Matsuda, W. Cui, H. Kato, S. Namiki, T. Yamazaki, M. Frauenlob, T. Nonoyama, M. Tsuda, S. Tanaka, T. Nakajima, J. P. Gong, Nat. Commun., 2022, 13,
DOI: 10.1038/s41467-022-34044-8
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An Autopsy Case Report of Adult-Onset Krabbe Disease: Comparison with an Infantile-Onset Case
, M. Ebata, Z. Tanei, Y. Oda, A. Hamauchi, S. Tanikawa, H. Sugino, Y. Ishida, T. Abe, N. Arai, K. Sako, S. Tanaka, Pathology International, 2022, ,
DOI: 10.1111/pin.13275
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Virological Characteristics of the SARS-CoV-2 Omicron BA.2.75 Variant
, T. Tamura, J. Zahradnik, S. Deguchi, K. Tabata, Y. Anraku, I. Kimura, J. Ito, D. Yamasoba, H. Nasser, M. Toyoda, K. Nagata, K. Uriu, Y. Kosugi, S. Fujita, M. Shofa, M. M. Begum, R. Shimizu, Y. Oda, R. Suzuki, H. Ito, N. Nao, L. Wang, M. Tsuda, K. Yoshimatsu, J. Kuramochi, S. Kita, K. Sasaki-Tabata, H. Fukuhara, K. Maenaka, Y. Yamamoto, T. Nagamoto, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, T. Ueno, G. Schreiber, A. Takaori-Kondo, K. Shirakawa, H. Sawa, T. Irie, T. Hashiguchi, K. Takayama, K. Matsuno, S. Tanaka, T. Ikeda, T. Fukuhara, K. Sato, G. P. J. Genotype Phenotype Japan, Cell Host & Microbe, 2022, 30, 1540-+
DOI: 10.1016/j.chom.2022.10.003
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Analysis of Clinicopathological Features and NAB2-STAT6 Fusion Variants of Meningeal Solitary Fibrous Tumor with Ectopic Salivary Gland Components in the Cerebellopontine Angle
, Y. Yamada, S. Nakata, B. Asayama, Y. Seo, S. Tanikawa, T. Kato, N. Komoribayashi, N. Kubo, N. Monma, N. Okura, S. Tanaka, Y. Oda, J. Hirato, H. Yokoo, S. Nobusawa, Virchows Archiv, 2022, ,
DOI: 10.1007/s00428-022-03403-7
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Evaluation of the Context of Downstream N- and Free N-Glycomic Alterations Induced by Swainsonine in HepG2 Cells
, K. Sugiura, K. Kondo, Y. Yamamoto, Y. Kojima, Y. Ozawa, H. Yoshioka, N. Miura, J. H. Piao, K. Okada, H. Hanamatsu, M. Tsuda, S. Tanaka, J. I. Furukawa, Y. Shinohara, Biochimica Et Biophysica Acta-General Subjects, 2022, 1866,
DOI: 10.1016/j.bbagen.2022.130168
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Neoatherosclerosis with Silent Plaque Rupture in a Saphenous Vein Graft Causing No Re-Flow Phenomenon Assessed by Optical Coherence Tomography and Histopathology
, Y. Takahashi, S. Kazui, Y. Yasui, K. Saiin, S. Naito, S. Takenaka, Y. Mizuguchi, A. Tada, Y. Kobayashi, K. Omote, T. Sato, K. Kamiya, T. Nagai, S. Tanaka, T. Anzai, Cardiology Journal, 2022, 29, 718-719
DOI: 10.5603/cj.2022.0063
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Virological Characteristics of the SARS-CoV-2 Omicron BA.2 Spike
, I. Kimura, H. Nasser, Y. Morioka, N. Nao, J. Ito, K. Uriu, M. Tsuda, J. Zahradnik, K. Shirakawa, R. Suzuki, M. Kishimoto, Y. Kosugi, K. Kobiyama, T. Hara, M. Toyoda, Y. L. Tanaka, E. P. Butlertanaka, R. Shimizu, H. Ito, L. Wang, Y. Oda, Y. Orba, M. Sasaki, K. Nagata, K. Yoshimatsu, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, J. Kuramochi, M. Seki, R. Fujiki, A. Kaneda, T. Shimada, T. Nakada, S. Sakao, T. Suzuki, T. Ueno, A. Takaori-Kondo, K. J. Ishii, G. Schreiber, H. Sawa, A. Saito, T. Irie, S. Tanaka, K. Matsuno, T. Fukuhara, T. Ikeda, K. Sato, Cell, 2022, 185, 2103-+
DOI: 10.1016/j.cell.2022.04.035
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Luseogliflozin Preserves the Pancreatic Beta-Cell Mass and Function in Db/db Mice by Improving Mitochondrial Function
, A. Nakamura, T. Yokota, K. Takahashi, S. Kawata, K. Tsuchida, K. Omori, H. Nomoto, H. Kameda, K. Y. Cho, T. Anzai, S. Tanaka, Y. Terauchi, H. Miyoshi, T. Atsumi, Scientific Reports, 2022, 12,
DOI: 10.1038/s41598-022-13888-6
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Protocol for a Sepsis Model Utilizing Fecal Suspension in Mice: Fecal Suspension Intraperitoneal Injection Model
, T. Wada, A. Mizugaki, Y. Oda, K. Kayano, K. Yamakawa, S. Tanaka, Frontiers in Medicine, 2022, 9,
DOI: 10.3389/fmed.2022.765805
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Clinical and Radiological Findings of Glioblastomas Harboring a BRAF V600E Mutation
, S. Yamaguchi, M. Okamoto, R. Sawaya, S. Endo, H. Motegi, S. Terasaka, Z. Tanei, K. C. Hatanaka, S. Tanaka, M. Fujimura, Brain Tumor Pathology, 2022, 39, 162-170
DOI: 10.1007/s10014-022-00432-7
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Attenuated Fusogenicity and Pathogenicity of SARS-CoV-2 Omicron Variant
, D. Yamasoba, I. Kimura, L. Wang, M. Kishimoto, J. Ito, Y. Morioka, N. Nao, H. Nasser, K. Uriu, Y. Kosugi, M. Tsuda, Y. Orba, M. Sasaki, R. Shimizu, R. Kawabata, K. Yoshimatsu, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, H. Sawa, T. Ikeda, T. Irie, K. Matsuno, S. Tanaka, T. Fukuhara, K. Sato, G. P. J. Genotype Phenotype Japan, Nature, 2022, 603, 700-+
DOI: 10.1038/s41586-022-04462-1
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Novel Rapid Immunohistochemistry Using an Alternating Current Electric Field Identifies Rac and Cdc42 Activation in Human Colon Cancer FFPE Tissues
, R. Horio, L. Wang, T. Takenami, J. Moriya, J. Suzuka, H. Sugino, Z. Tanei, M. Tanino, S. Tanaka, Scientific Reports, 2022, 12,
DOI: 10.1038/s41598-022-05892-7
2021年
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Enhanced Fusogenicity and Pathogenicity of SARS-CoV-2 Delta P681R Mutation
, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Q. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, S. Loeber, M. Tsuda, L. Wang, S. Ozono, E. P. Butlertanaka, Y. L. Tanaka, R. Shimizu, K. Shimizu, K. Yoshimatsu, R. Kawabata, T. Sakaguchi, K. Tokunaga, I. Yoshida, H. Asakura, M. Nagashima, Y. Kazuma, R. Nomura, Y. Horisawa, K. Yoshimura, A. Takaori-Kondo, M. Imai, S. Tanaka, S. Nakagawa, T. Ikeda, T. Fukuhara, Y. Kawaoka, K. Sato, G. P. J. Genotype Phenotype Japan, Nature, 2021, 602, 300-+
DOI: 10.1038/s41586-021-04266-9
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Loss of FAM83H Promotes Cell Migration and Invasion in Cutaneous Squamous Cell Carcinoma via Impaired Keratin Distribution
, S. Kitamura, T. Maeda, M. Watanabe, S. Hatakeyama, S. Kano, S. Tanaka, H. Ujiie, T. Yanagi, Journal of Dermatological Science, 2021, 104, 112-121
DOI: 10.1016/j.jdermsci.2021.09.007
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Hydroxyapatite-Hybridized Double-Network Hydrogel Surface Enhances Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells to Osteogenic Cells
, L. Wang, M. Tsuda, T. Nonoyama, T. Kurokawa, N. Iwasaki, J. P. Gong, S. Tanaka, K. Yasuda, Journal of Biomedical Materials Research Part A, 2021, 110, 747-760
DOI: 10.1002/jbm.a.37324
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Aberrant Expression of MYD88 via RNA-Controlling CNOT4 and EXOSC3 in Colonic Mucosa Impacts Generation of Colonic Cancer
, M. Noguchi, T. Kurai, Y. Ichihashi, K. Ise, L. Wang, Y. Ishida, M. Tanino, S. Hirano, M. Asaka, S. Tanaka, Cancer Sci., 2021, 112, 5100-5113
DOI: 10.1111/cas.15157
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Fast in Vivo Fixation of Double Network Hydrogel to Bone by Monetite Surface Hybridization
, L. Wang, R. Kiyama, N. Kashimura, K. Yasuda, S. Tanaka, T. Kurokawa, J. P. Gong, Journal of the Ceramic Society of Japan, 2021, 129, 584-589
DOI: 10.2109/jcersj2.21084
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Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
, M. Tekguc, J. B. Wing, A. Hashimoto, D. Okuzaki, T. Hirata, A. Sasaki, T. Itokazu, H. Handa, H. Sugino, Y. Nishikawa, H. Metwally, Y. Kodama, S. Tanaka, H. Sabe, T. Yamashita, S. Sakaguchi, T. Kishimoto, S. Hashimoto, Cancer Immunology Research, 2021, 9, 862-876
DOI: 10.1158/2326-6066.cir-21-0014
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The CD44/COL17A1 Pathway Promotes the Formation of Multilayered, Transformed Epithelia
, M. Sekai, K. Ohba, S. Ito, H. Sako, T. Maruyama, M. Kakeno, T. Shirai, K. Kuromiya, T. Kamasaki, K. Kohashi, S. Tanaka, S. Ishikawa, N. Sato, S. Asano, H. Suzuki, N. Tanimura, Y. Mukai, N. Gotoh, M. Tanino, K. Natsuga, T. Soga, T. Nakamura, Y. Yabuta, M. Saitou, T. Ito, K. Matsuura, M. Tsunoda, T. Kikumori, T. Iida, Y. Mizutani, Y. Miyai, K. Kaibuchi, A. Enomoto, Y. Fujita, Current Biology, 2021, 31, 3086-+
DOI: 10.1016/j.cub.2021.04.078
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Difference in the Malignancy between RAS and GLI1-Transformed Astrocytes Is Associated with Frequency of p27(KIP1)-Positive Cells in Xenograft Tissues
, K. Tabu, T. Saito, Y. Matsuba, T. C. Saido, S. Tanaka, Pathology Research and Practice, 2021, 223,
DOI: 10.1016/j.prp.2021.153465
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Comprehensive Molecular Profiling of Pulmonary Pleomorphic Carcinoma
, S. Kohsaka, T. Hayashi, T. Ueno, S. Kojima, A. Shinozaki-Ushiku, S. Morita, M. Tsuda, S. Tanaka, T. Shinohara, Y. Omori, F. Sugaya, H. Kato, Y. Narita, J. Nakajima, K. Suzuki, K. Takamochi, H. Mano, Npj Precision Oncology, 2021, 5,
DOI: 10.1038/s41698-021-00201-3
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Loss of H3K27 Trimethylation Is Frequent in IDH1-R132H but Not in Non-Canonical IDH1/2 Mutated and 1p/19q Codeleted Oligodendroglioma: A Japanese Cohort Study
, H. Sugino, R. Yordanova, K. Ise, Z. Tanei, Y. Ishida, S. Tanikawa, S. Terasaka, K. Sato, Y. Kamoshima, M. Katoh, M. Nagane, J. Shibahara, M. Tsuda, S. Tanaka, Acta Neuropathologica Communications, 2021, 9,
DOI: 10.1186/s40478-021-01194-7
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High-Grade Neuroepithelial Tumor with BCL6 Corepressor-Alteration Presenting Pathological and Radiological Calcification: A Case Report
, A. Shimizu, E. Takakuwa, M. Sugiyama, M. Okamoto, H. Motegi, S. Hirabayashi, Y. Cho, A. Iguchi, A. Manabe, S. Nobusawa, S. Tanaka, S. Yamaguchi, Pathology International, 2021, 71, 348-354
DOI: 10.1111/pin.13083
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Severe Infection Including Disseminated Herpes Zoster Triggered by Subclinical Cushing's Disease: A Case Report
, H. Kameda, K. Omori, M. Tani, K. Y. Cho, A. Nakamura, H. Miyoshi, S. Tanaka, T. Atsumi, Bmc Endocrine Disorders, 2021, 21, 6
DOI: 10.1186/s12902-021-00757-y
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Involvement of BMP and Wnt Signals Leading to Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification
, M. Tsuda, J. Suzuka, Y. Oda, L. Wang, Z. Tanei, M. Tanino, T. Ohata, E. Nagabuchi, Y. Ishida, S. Kimura, T. Iwanaga, S. Tanaka, Annals of Clinical and Laboratory Science, 2021, 51, 271-276
DOI:
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Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
DOI: 10.1038/s41551-021-00692-2
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Ependymoma-like Tumor with Mesenchymal Differentiation Harboring C11orf95-NCOA1/2 or -RELA Fusion: A Hitherto Unclassified Tumor Related to Ependymoma
, Y. Arai, R. Kawabata-Iwakawa, K. Fukuoka, Y. Nakano, N. Hama, S. Nakata, N. Suzuki, Y. Ishi, S. Tanaka, J. A. Takahashi, Y. Yuba, M. Shiota, A. Natsume, M. Kurimoto, Y. Shiba, M. Aoki, K. Nabeshima, T. Enomoto, T. Inoue, J. Fujimura, A. Kondo, T. Yao, N. Okura, T. Hirose, A. Sasaki, M. Nishiyama, K. Ichimura, T. Shibata, J. Hirato, H. Yokoo, S. Nobusawa, Brain Pathology, 2021, , 14
DOI: 10.1111/bpa.12943
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Lewy Pathology of the Esophagus Correlates with the Progression of Lewy Body Disease: A Japanese Cohort Study of Autopsy Cases
, Y. Saito, S. Ito, T. Matsubara, A. Motoda, M. Yamazaki, Y. Sakashita, I. Kawakami, M. Ikemura, S. Tanaka, R. Sengoku, T. Arai, S. Murayama, Acta Neuropathologica, 2021, 141, 25-37
DOI: 10.1007/s00401-020-02233-8
2020年
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Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target
, T. Nakamura, M. Tsuda, T. Tsuchikawa, K. Hontani, K. Inoko, M. Takahashi, T. Asano, K. Okamura, S. Murakami, Y. Kurashima, Y. Ebihara, T. Noji, Y. Nakanishi, K. Tanaka, N. Maishi, K. Sasaki, WR. Park, T. Shichinohe, K. Hida, S. Tanaka, S. Hirano, Mol. Cancer Ther., 2020, 19, 187-198
DOI: 10.1158/1535-7163.MCT-19-0491
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Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone
, L. Wang, M. Tsuda, Y. Suzuki, R. Kiyama, K. Yasuda, S. Tanaka, K. Nagata, R. Fujita, N. Sakamoto, N. Kawasaki, H. Yurimoto, J. P. Gong, Advanced Healthcare Materials, 2020, ,
DOI: 10.1002/adhm.202001731
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Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
, M. Frauenlob, Y. Shibata, L. Wang, T. Nakajima, T. Nonoyama, M. Tsuda, S. Tanaka, T. Kurokawa, J. P. Gong, Biomacromolecules, 2020, 21, 4220-4230
DOI: 10.1021/acs.biomac.0c01033
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Integrin Alpha 4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiation
, S. Semba, M. Tsuda, T. Kurokawa, N. Kitamura, K. Yasuda, J. P. Gong, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 528, 120-126
DOI: 10.1016/j.bbrc.2020.05.071
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Synthetic Poly(2-Acrylamido-2-Methylpropanesulfonic Acid) Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
, N. Kitamura, M. Tsuda, K. Goto, S. Kurono, Y. Ohmiya, T. Kurokawa, J. P. Gong, K. Yasuda, S. Tanaka, Journal of Biomedical Materials Research Part A, 2020, ,
DOI: 10.1002/jbm.a.37028
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Chiral Monolayers with Achiral Tetrapod Molecules on Highly Oriented Pyrolytic Graphite
, S. Matsui, Q. T. Trinh, H. Hirao, Y. Inokuma, T. Ogoshi, S. Tanaka, K. Komatsu, A. Ohta, T. Asakawa, T. Fukuma, J. Phys. Chem. C, 2020, 124, 7760-7767
DOI: 10.1021/acs.jpcc.9b11246
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Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus
, E. Hossain, A. Yanagawa-Matsuda, A. Chowdhury, M. Tsuda, A. U. Zaman, S. Tanaka, F. Higashino, Cancers, 2020, 12, 14
DOI: 10.3390/cancers12040809
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Signaling Adaptor Protein Crk Is Involved in Malignant Feature of Pancreatic Cancer Associated with Phosphorylation of c-Met
, L. Wang, M. Tsuda, J. Suzuka, S. Tanikawa, H. Sugino, T. Nakamura, T. Mitsuhashi, S. Hirano, S. Tanaka, Biochemical and Biophysical Research Communications, 2020, 524, 378-384
DOI: 10.1016/j.bbrc.2020.01.105
2019年
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Modulation and Characterization of the Double Network Hydrogel Surface-Bulk Transition
, DR. King, HL. Guo, S. Ishihara, M. Tsuda, T. Kurokawa, H. Haga, S. Tanaka, JP. Gong, Macromolecules, 2019, 52, 6704-6713
DOI: 10.1021/acs.macromol.9b01399
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Autopsy Findings in the Early Stage of Amyotrophic Lateral Sclerosis with "Dropped Head" Syndrome
, M. Tanino, L. Wang, M. Ishikawa, M. Miyazaki, M. Tsuda, Y. Orba, H. Sawa, K. Matoba, N. Nakamura, K. Nagashima, WW. Hall, S. Tanaka, Neuropathology, 2019, 39, 374-377
DOI: 10.1111/neup.12583
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Exosomes Containing ErbB2/CRK Induce Vascular Growth in Premetastatic Niches and Promote Metastasis of Bladder Cancer
, M. Tsuda, R. Matsumoto, S. Semba, L. Wang, H. Sugino, M. Tanino, T. Kondo, K. Tanabe, S. Tanaka, Cancer Sci., 2019, 110, 2119-2132
DOI: 10.1111/cas.14080
2018年
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miR-23a Promotes Invasion of Glioblastoma via HOXD10-Regulated Glial-Mesenchymal Transition
, M. Tsuda, S. Kohsaka, L. Wang, Y. Oda, S. Tanikawa, Y. Ohba, S. Tanaka, Signal Transduction and Targeted Therapy, 2018, 3,
DOI: 10.1038/s41392-018-0033-6