(ワンレイ)

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(ワンレイ)
連絡先

wanglei atmark icredd.hokudai.ac.jp

田中 伸哉 グループ
主任研究者
教員
博士研究員
研究協力者

研究紹介

研究テーマ

バイオマテリアルによる新規癌幹細胞治療法および革新的再生医療の開発

キーワード

がん、がん幹細胞、分子標的療法、遺伝子診断、生体材料
研究概要

生体材料を用いてがん幹細胞を誘導及び解析し、病気を深く理解し、個別化医療に応用します。

代表的な研究成果

  • Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications
    Y. N. Ye, M. Frauenlob, L. Wang, M. Tsuda, T. L. Sun, K. Cui, R. Takahashi, H. J. Zhang, T. Nakajima, T. Nonoyama, T. Kurokawa, S. Tanaka, J. P. Gong, Advanced Functional Materials, 2018, 28, 1801489
    DOI : 10.1002/adfm.201801489
  • Identification and Analysis of CXCR4-Positive Synovial Sarcoma Initiating Cells
    T. Kimura, L. Wang, K. Tabu, M. Tsuda, M. Tanino, A. Maekawa, H. Nishihara, Hiraga, T. Taga, Y. Oda, S. Tanaka, Oncogene, 2016, 35, 3932-3943
    DOI: 10.1038/onc.2015.461
  • Sustained Elevation of Snail Promotes Glial-Mesenchymal Transition after Irradiation in Malignant Glioma
    R. Mahabir, M. Tanino, A. Elmansuri, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, S. Tanaka, Neuro Oncol, 2014, 5, 671-685
    DOI: 10.1093/neuonc/not239
  • STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
    S. Kohsaka, L. Wang, K. Yachi, R. Mahabir, T. Narita, T. Itoh, M. Tanino, T. Kimura, H. Nishihara, S. Tanaka, Mol Cancer Ther, 2012, 11, 1289-1299
    DOI: 10.1158/1535-7163.MCT-11-0801
  • Signaling Adaptor Protein Crk is Indispensable for Malignant Feature of Glioblastoma Cell Line KMG4
    L. Wang, K. Tabu, T. Kimura, M. Tsuda, H. Linghu, M. Tanino, S. Kaneko, H. Nishihara, S. Tanaka, Biochem Biophys Res Commun, 2007, 362, 976-981
    DOI: 10.1016/j.bbrc.2007.08.106

関連する研究記事

業績一覧

2021年

  • Fast in Vivo Fixation of Double Network Hydrogel to Bone by Monetite Surface Hybridization
    T. Nonoyama, L. Wang, R. Kiyama, N. Kashimura, K. Yasuda, S. Tanaka, T. Kurokawa, J. P. Gong, Journal of the Ceramic Society of Japan, 2021, 129, 584-589
    DOI: 10.2109/jcersj2.21084
  • Involvement of BMP and Wnt Signals Leading to Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification
    N. Katono, M. Tsuda, J. Suzuka, Y. Oda, L. Wang, Z. Tanei, M. Tanino, T. Ohata, E. Nagabuchi, Y. Ishida, S. Kimura, T. Iwanaga, S. Tanaka, Annals of Clinical and Laboratory Science, 2021, 51, 271-276
    DOI:
  • Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    J. Suzuka, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
    DOI: 10.1038/s41551-021-00692-2