About the Research
Research Theme
Development of new cancer stem cell therapies and innovative regenerative medicine using biomaterials
Keyword
Cancer, cancer stem cells, molecular targeted therapy, genetic diagnosis, biomaterials
Research Outline
Analyzing cancer stem cells using biomaterials, deeply understand the disease and apply it to personalized medicine.
Representative Research Achievements
- Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications
Y. N. Ye, M. Frauenlob, L. Wang, M. Tsuda, T. L. Sun, K. Cui, R. Takahashi, H. J. Zhang, T. Nakajima, T. Nonoyama, T. Kurokawa, S. Tanaka, J. P. Gong, Advanced Functional Materials, 2018, 28, 1801489
DOI : 10.1002/adfm.201801489 - Identification and Analysis of CXCR4-Positive Synovial Sarcoma Initiating Cells
T. Kimura, L. Wang, K. Tabu, M. Tsuda, M. Tanino, A. Maekawa, H. Nishihara, Hiraga, T. Taga, Y. Oda, S. Tanaka, Oncogene, 2016, 35, 3932-3943
DOI: 10.1038/onc.2015.461 - Sustained Elevation of Snail Promotes Glial-Mesenchymal Transition after Irradiation in Malignant Glioma
R. Mahabir, M. Tanino, A. Elmansuri, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, S. Tanaka, Neuro Oncol, 2014, 5, 671-685
DOI: 10.1093/neuonc/not239 - STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
S. Kohsaka, L. Wang, K. Yachi, R. Mahabir, T. Narita, T. Itoh, M. Tanino, T. Kimura, H. Nishihara, S. Tanaka, Mol Cancer Ther, 2012, 11, 1289-1299
DOI: 10.1158/1535-7163.MCT-11-0801 - Signaling Adaptor Protein Crk is Indispensable for Malignant Feature of Glioblastoma Cell Line KMG4
L. Wang, K. Tabu, T. Kimura, M. Tsuda, H. Linghu, M. Tanino, S. Kaneko, H. Nishihara, S. Tanaka, Biochem Biophys Res Commun, 2007, 362, 976-981
DOI: 10.1016/j.bbrc.2007.08.106
Related Research
- Reduced pathogenicity of Omicron XBB.1.5 variant found to be due in part to a mutation-induced decrease in immunosuppression function
- Omicron BA.2.86 variant shown to have comparatively higher epidemic spreading ability but lower pathogenicity
- SARS-CoV-2 XBB revealed to be first variant derived from recombination of two other Omicron subvariants
- Shedding light on the evolutionary rules of SARS-CoV-2 Omicron variants
- BA.4 and BA.5 subvariants of COVID show higher pathogenicity and higher resistance to natural and vaccine-induced immunity
- Press Release Understanding the virological characteristics of the SARS-CoV-2 Omicron BA.2 spike
- COVID Omicron variant exhibits decreased lung infection but higher transmissibility
- New method enables spatial detection of regulatory factors associated with cancer tumor invasion
- One step closer to artificial cartilage. Hydrogels show signs of triggering bone marrow stem cells to change into bone-like cells
- Mutation in COVID Delta variant associated with increased pathogenicity and fusogenicity
- Uprooting cancer: Hydrogel rapidly reverts cancer cells back to cancer stem cells
Publications
2024
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Virological Characteristics of the SARS-CoV-2 Omicron XBB.1.5 Variant
, T. Irie, S. Deguchi, H. Yajima, M. Tsuda, H. Nasser, K. Mizuma, A. Plianchaisuk, S. Suzuki, K. Uriu, M. M. Begum, R. Shimizu, M. Jonathan, R. Suzuki, T. Kondo, H. Ito, A. Kamiyama, K. Yoshimatsu, M. Shofa, R. Hashimoto, Y. Anraku, K. T. Kimura, S. Kita, J. Sasaki, K. Sasaki-Tabata, K. Maenaka, N. Nao, L. Wang, Y. Oda, H. Sawa, R. Kawabata, Y. Watanabe, A. Sakamoto, N. Yasuhara, T. Suzuki, Y. Nakajima, Z. Ferdous, K. Shishido, Y. Mugita, O. Takahashi, K. Ichihara, Y. Kaku, N. Misawa, Z. Y. Guo, A. Hinay, Y. Kosugi, S. Fujita, J. M. Tolentino, L. Chen, L. Pan, M. Suganami, M. Chiba, R. Yoshimura, K. Yasuda, K. Iida, N. Ohsumi, A. P. Strange, Y. Shibatani, T. Nishiuchi, S. Tanaka, O. Putri, G. Joas, Y. Kim, D. Yamasoba, K. Yoshimura, K. Sadamasu, M. Nagashima, H. Asakura, I. Yoshida, S. Nakagawa, A. Takaori-Kondo, K. Shirakawa, K. Nagata, R. Nomura, Y. Horisawa, Y. Tashiro, Y. Kawai, T. Ueno, C. Motozono, M. Toyoda, T. Ikeda, A. Saito, K. Matsuno, J. Ito, K. Sato, T. Hashiguchi, K. Takayama, T. Fukuhara, G. P. Genotype Phenotype Japan, Nat. Commun., 2024, 15,
DOI: 10.1038/s41467-024-45274-3
2023
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Comparative Pathogenicity of SARS-CoV-2 Omicron Subvariants Including BA.1, BA.2, and BA.5
, D. Yamasoba, Y. Oda, J. Ito, T. Kamasaki, N. Nao, R. Hashimoto, Y. Fujioka, R. Suzuki, L. Wang, H. Ito, Y. Kashima, I. Kimura, M. Kishimoto, M. Tsuda, H. Sawa, K. Yoshimatsu, Y. Yamamoto, T. Nagamoto, J. Kanamune, Y. Suzuki, Y. Ohba, I. Yokota, K. Matsuno, K. Takayama, S. Tanaka, K. Sato, T. Fukuhara, G. P. J. Genotype Phenotype Japan, Communications Biology, 2023, 6, Article number: 772
DOI: 10.1038/s42003-023-05081-w
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Convergent Evolution of SARS-CoV-2 Omicron Subvariants Leading to the Emergence of BQ.1.1 Variant
, R. Suzuki, K. Uriu, Y. Itakura, J. Zahradnik, K. T. Kimura, S. Deguchi, L. Wang, S. Lytras, T. Tamura, I. Kida, H. Nasser, M. Shofa, M. M. Begum, M. Tsuda, Y. Oda, T. Suzuki, J. Sasaki, K. Sasaki-Tabata, S. Fujita, K. Yoshimatsu, H. Ito, N. Nao, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, Y. Yamamoto, T. Nagamoto, J. Kuramochi, G. Schreiber, A. Saito, K. Matsuno, K. Takayama, T. Hashiguchi, S. Tanaka, T. Fukuhara, T. Ikeda, K. Sato, S. Suzuki, M. Kato, Z. Ferdous, H. Mouri, K. Shishido, N. Misawa, I. Kimura, Y. Kosugi, P. Lin, M. Suganami, M. Chiba, R. Yoshimura, K. Yasuda, K. Iida, N. Ohsumi, A. P. Strange, D. Sauter, S. Nakagawa, J. Q. Wu, Y. Watanabe, A. Sakamoto, N. Yasuhara, Y. Nakajima, H. Yajima, K. Shirakawa, A. Takaori-Kondo, K. Nagata, Y. Kazuma, R. Nomura, Y. Horisawa, Y. Tashiro, Y. Kawa, T. Irie, R. Kawabata, R. Shimizu, O. Takahashi, K. Ichihara, C. Motozono, M. Toyoda, T. Ueno, Y. Shibatani, T. Nishiuchi, G. P. J. Genotype Phenotype Japan, Nat. Commun., 2023, 14, 2671,
DOI: 10.1038/s41467-023-38188-z
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Virological Characteristics of the SARS-CoV-2 XBB Variant Derived from Recombination of Two Omicron Subvariants
, J. Ito, K. Uriu, J. Zahradnik, I. Kida, Y. Anraku, H. Nasser, M. Shofa, Y. Oda, S. Lytras, N. Nao, Y. Itakura, S. Deguchi, R. Suzuki, L. Wang, M. Begum, S. Kita, H. Yajima, J. Sasaki, K. Sasaki-Tabata, R. Shimizu, M. Tsuda, Y. Kosugi, S. Fujita, L. Pan, D. Sauter, K. Yoshimatsu, S. Suzuki, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, Y. Yamamoto, T. Nagamoto, G. Schreiber, K. Maenaka, T. Hashiguchi, T. Ikeda, T. Fukuhara, A. Saito, S. Tanaka, K. Matsuno, K. Takayama, K. Sato, G. P. J. Genotype Phenotype Japan, Nat. Commun., 2023, 14, 2671
DOI: 10.1038/s41467-023-38435-3
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Combination Therapy with Bevacizumab and a CCR2 Inhibitor for Human Ovarian Cancer: An in Vivo Validation Study
, T. Mitamura, L. Wang, S. I. Kubota, M. Murakami, S. Tanaka, H. Watari, Cancer Medicine, 2023, ,
DOI: 10.1002/cam4.5674
2022
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Germline PRDM1 Variant Rs2185379 in Long-Term Recurrence-Free Survivors of Advanced Ovarian Cancer
, T. Zhai, K. C. Hatanaka, Y. Hatanaka, T. Amano, L. Wang, S. Tanaka, H. Watari, Pharmacogenomics & Personalized Medicine, 2022, 15, 977-984
DOI: 10.2147/pgpm.s387120
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Virological Characteristics of the SARS-CoV-2 Omicron BA.2 Subvariants, Including BA.4 and BA.5
, D. Yamasoba, T. Tamura, N. Nao, T. Suzuki, Y. Oda, S. Mitoma, J. Ito, H. Nasser, J. Zahradnik, K. Uriu, S. Fujita, Y. Kosugi, L. Wang, M. Tsuda, M. Kishimoto, H. Ito, R. Suzuki, R. Shimizu, M. M. Begum, K. Yoshimatsu, K. T. Kimura, J. Sasaki, K. Sasaki-Tabata, Y. Yamamoto, T. Nagamoto, J. Kanamune, K. Kobiyama, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, K. Shirakawa, A. Takaori-Kondo, J. Kuramochi, G. Schreiber, K. J. Ishii, T. Hashiguchi, T. Ikeda, A. Saito, T. Fukuhara, S. Tanaka, K. Matsuno, K. Sato, G. P. J. Genotype Phenotype Japan, Cell, 2022, 185, 3992-4007.e16
DOI: 10.1016/j.cell.2022.09.018
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Virological Characteristics of the SARS-CoV-2 Omicron BA.2.75 Variant
, T. Tamura, J. Zahradnik, S. Deguchi, K. Tabata, Y. Anraku, I. Kimura, J. Ito, D. Yamasoba, H. Nasser, M. Toyoda, K. Nagata, K. Uriu, Y. Kosugi, S. Fujita, M. Shofa, M. M. Begum, R. Shimizu, Y. Oda, R. Suzuki, H. Ito, N. Nao, L. Wang, M. Tsuda, K. Yoshimatsu, J. Kuramochi, S. Kita, K. Sasaki-Tabata, H. Fukuhara, K. Maenaka, Y. Yamamoto, T. Nagamoto, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, T. Ueno, G. Schreiber, A. Takaori-Kondo, K. Shirakawa, H. Sawa, T. Irie, T. Hashiguchi, K. Takayama, K. Matsuno, S. Tanaka, T. Ikeda, T. Fukuhara, K. Sato, G. P. J. Genotype Phenotype Japan, Cell Host & Microbe, 2022, 30, 1540-+
DOI: 10.1016/j.chom.2022.10.003
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Virological Characteristics of the SARS-CoV-2 Omicron BA.2 Spike
, I. Kimura, H. Nasser, Y. Morioka, N. Nao, J. Ito, K. Uriu, M. Tsuda, J. Zahradnik, K. Shirakawa, R. Suzuki, M. Kishimoto, Y. Kosugi, K. Kobiyama, T. Hara, M. Toyoda, Y. L. Tanaka, E. P. Butlertanaka, R. Shimizu, H. Ito, L. Wang, Y. Oda, Y. Orba, M. Sasaki, K. Nagata, K. Yoshimatsu, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, J. Kuramochi, M. Seki, R. Fujiki, A. Kaneda, T. Shimada, T. Nakada, S. Sakao, T. Suzuki, T. Ueno, A. Takaori-Kondo, K. J. Ishii, G. Schreiber, H. Sawa, A. Saito, T. Irie, S. Tanaka, K. Matsuno, T. Fukuhara, T. Ikeda, K. Sato, Cell, 2022, 185, 2103-+
DOI: 10.1016/j.cell.2022.04.035
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Attenuated Fusogenicity and Pathogenicity of SARS-CoV-2 Omicron Variant
, D. Yamasoba, I. Kimura, L. Wang, M. Kishimoto, J. Ito, Y. Morioka, N. Nao, H. Nasser, K. Uriu, Y. Kosugi, M. Tsuda, Y. Orba, M. Sasaki, R. Shimizu, R. Kawabata, K. Yoshimatsu, H. Asakura, M. Nagashima, K. Sadamasu, K. Yoshimura, H. Sawa, T. Ikeda, T. Irie, K. Matsuno, S. Tanaka, T. Fukuhara, K. Sato, G. P. J. Genotype Phenotype Japan, Nature, 2022, 603, 700-+
DOI: 10.1038/s41586-022-04462-1
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Novel Rapid Immunohistochemistry Using an Alternating Current Electric Field Identifies Rac and Cdc42 Activation in Human Colon Cancer FFPE Tissues
, R. Horio, L. Wang, T. Takenami, J. Moriya, J. Suzuka, H. Sugino, Z. Tanei, M. Tanino, S. Tanaka, Scientific Reports, 2022, 12,
DOI: 10.1038/s41598-022-05892-7
2021
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Enhanced Fusogenicity and Pathogenicity of SARS-CoV-2 Delta P681R Mutation
, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Q. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, S. Loeber, M. Tsuda, L. Wang, S. Ozono, E. P. Butlertanaka, Y. L. Tanaka, R. Shimizu, K. Shimizu, K. Yoshimatsu, R. Kawabata, T. Sakaguchi, K. Tokunaga, I. Yoshida, H. Asakura, M. Nagashima, Y. Kazuma, R. Nomura, Y. Horisawa, K. Yoshimura, A. Takaori-Kondo, M. Imai, S. Tanaka, S. Nakagawa, T. Ikeda, T. Fukuhara, Y. Kawaoka, K. Sato, G. P. J. Genotype Phenotype Japan, Nature, 2021, 602, 300-+
DOI: 10.1038/s41586-021-04266-9
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Hydroxyapatite-Hybridized Double-Network Hydrogel Surface Enhances Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells to Osteogenic Cells
, L. Wang, M. Tsuda, T. Nonoyama, T. Kurokawa, N. Iwasaki, J. P. Gong, S. Tanaka, K. Yasuda, Journal of Biomedical Materials Research Part A, 2021, 110, 747-760
DOI: 10.1002/jbm.a.37324
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Aberrant Expression of MYD88 via RNA-Controlling CNOT4 and EXOSC3 in Colonic Mucosa Impacts Generation of Colonic Cancer
, M. Noguchi, T. Kurai, Y. Ichihashi, K. Ise, L. Wang, Y. Ishida, M. Tanino, S. Hirano, M. Asaka, S. Tanaka, Cancer Sci., 2021, 112, 5100-5113
DOI: 10.1111/cas.15157
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Fast in Vivo Fixation of Double Network Hydrogel to Bone by Monetite Surface Hybridization
, L. Wang, R. Kiyama, N. Kashimura, K. Yasuda, S. Tanaka, T. Kurokawa, J. P. Gong, Journal of the Ceramic Society of Japan, 2021, 129, 584-589
DOI: 10.2109/jcersj2.21084
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Involvement of BMP and Wnt Signals Leading to Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification
, M. Tsuda, J. Suzuka, Y. Oda, L. Wang, Z. Tanei, M. Tanino, T. Ohata, E. Nagabuchi, Y. Ishida, S. Kimura, T. Iwanaga, S. Tanaka, Annals of Clinical and Laboratory Science, 2021, 51, 271-276
DOI:
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Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
DOI: 10.1038/s41551-021-00692-2