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wanglei atmark

TANAKA, Shinya Group
Principal Investigator
Faculty Members
Postdoctoral Fellows
Research Collaborators

About the Research

Research Theme

Development of new cancer stem cell therapies and innovative regenerative medicine using biomaterials


Cancer, cancer stem cells, molecular targeted therapy, genetic diagnosis, biomaterials
Research Outline

Analyzing cancer stem cells using biomaterials, deeply understand the disease and apply it to personalized medicine.

Representative Research Achievements

  • Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications
    Y. N. Ye, M. Frauenlob, L. Wang, M. Tsuda, T. L. Sun, K. Cui, R. Takahashi, H. J. Zhang, T. Nakajima, T. Nonoyama, T. Kurokawa, S. Tanaka, J. P. Gong, Advanced Functional Materials, 2018, 28, 1801489
    DOI : 10.1002/adfm.201801489
  • Identification and Analysis of CXCR4-Positive Synovial Sarcoma Initiating Cells
    T. Kimura, L. Wang, K. Tabu, M. Tsuda, M. Tanino, A. Maekawa, H. Nishihara, Hiraga, T. Taga, Y. Oda, S. Tanaka, Oncogene, 2016, 35, 3932-3943
    DOI: 10.1038/onc.2015.461
  • Sustained Elevation of Snail Promotes Glial-Mesenchymal Transition after Irradiation in Malignant Glioma
    R. Mahabir, M. Tanino, A. Elmansuri, L. Wang, T. Kimura, T. Itoh, Y. Ohba, H. Nishihara, H. Shirato, M. Tsuda, S. Tanaka, Neuro Oncol, 2014, 5, 671-685
    DOI: 10.1093/neuonc/not239
  • STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
    S. Kohsaka, L. Wang, K. Yachi, R. Mahabir, T. Narita, T. Itoh, M. Tanino, T. Kimura, H. Nishihara, S. Tanaka, Mol Cancer Ther, 2012, 11, 1289-1299
    DOI: 10.1158/1535-7163.MCT-11-0801
  • Signaling Adaptor Protein Crk is Indispensable for Malignant Feature of Glioblastoma Cell Line KMG4
    L. Wang, K. Tabu, T. Kimura, M. Tsuda, H. Linghu, M. Tanino, S. Kaneko, H. Nishihara, S. Tanaka, Biochem Biophys Res Commun, 2007, 362, 976-981
    DOI: 10.1016/j.bbrc.2007.08.106

Related Research



  • Involvement of BMP and Wnt Signals Leading to Epithelial-Mesenchymal Transition in Colon Adenocarcinoma with Heterotopic Ossification
    N. Katono, M. Tsuda, J. Suzuka, Y. Oda, L. Wang, Z. Tanei, M. Tanino, T. Ohata, E. Nagabuchi, Y. Ishida, S. Kimura, T. Iwanaga, S. Tanaka, Annals of Clinical and Laboratory Science, 2021, 51, 271-276
  • Rapid Reprogramming of Tumour Cells into Cancer Stem Cells on Double-Network Hydrogels
    J. Suzuka, M. Tsuda, L. Wang, S. Kohsaka, K. Kishida, S. Semba, H. Sugino, S. Aburatani, M. Frauenlob, T. Kurokawa, S. Kojima, T. Ueno, Y. Ohmiya, H. Mano, K. Yasuda, J. P. Gong, S. Tanaka, Nature Biomedical Engineering, 2021, , 15
    DOI: 10.1038/s41551-021-00692-2