TSUJI, Nobuya

TSUJI, Nobuya

Specially Appointed Associate Professor

Co-PI (List Group)

tsuji atmark icredd.hokudai.ac.jp

Asymmetric Brønsted acid/Lewis acid catalysis

Asymmetric catalysis, Organocatalysis

See my CV.

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Activation of olefins via asymmetric Brønsted acid catalysis
N. Tsuji, J. L. Kennemur, T. Buyck, S. Lee, S. Prévost, P. S. J. Kaib, D. Bykov, C. Farès, B. List, Science, 2018, 359, 1501–1505
DOI: 10.1126/science.aaq0445
Predicting Highly Enantioselective Catalysts Using Tunable Fragment Descriptors
N. Tsuji, P. Sidorov, C. D. Zhu, Y. Nagata, T. Gimadiev, A. Varnek, B. List, Angew. Chem., Int. Ed., 2023, e202218659,
DOI: 10.1002/anie.202218659
Catalytic asymmetric fragmentation of cyclopropanes
R. K. Raut, S. Matsutani, F. Shi, S. Kataoka, M. Poje, B. Mitschke, S. Maeda, N. Tsuji*, B. List*, Science, 2024, 386, 225–230.
DOI: 10.1126/science.adp9061

Catalytic Asymmetric (ene-endo)-Carbonyl-Ene Type Cyclizations
L. Shi, N. Tsuji, C. Zhu, M. Leutzsch, J. Grimm, B. List, J. Am. Chem. Soc., 2025, 147, 38, 34225–34230
DOI: 10.1021/jacs.5c11553
The Overlooked Stereoisomers of the Ionizable Lipid ALC315
C. De, M. Tsuda, C. Zhu, S. Dehn, H. Hinrichs, N. Tsuji, H. Jin, H. Arase, S. Tanaka, B. List, J. Am. Chem. Soc., 2025, 147, 28595-28600
DOI: 10.1021/jacs.5c08345

Catalytic Asymmetric Fragmentation of Cyclopropanes
R. Raut, S. Matsutani, F. Shi, S. Kataoka, M. Poje, B. Mitschke, S. Maeda, N. Tsuji, B. List, Science, 2024, 386, 225-230
DOI: 10.1126/science.adp9061
Highly Acidic Electron-Rich Brønsted Acids Accelerate Asymmetric Pictet-Spengler Reactions by Virtue of Stabilizing Cation-π Interactions
M. Scharf, N. Tsuji, M. Lindner, M. Leutzsch, M. Lökov, E. Parman, I. Leito, B. List, J. Am. Chem. Soc., 2024, 146, Issue 41, 28339-28349
DOI: 10.1021/jacs.4c09421
Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silacycles
J. Han, N. Tsuji, H. Zhou, M. Leutzsch, B. List, Nat. Commun., 2024, 15, Article number: 5846
DOI: 10.1038/s41467-024-49988-2
Catalytic Asymmetric Cationic Shifts of Aliphatic Hydrocarbons
V. N. Wakchaure, W. DeSnoo, C. J. Laconsay, M. Leutzsch, N. Tsuji, D. J. Tantillo, B. List, Nature, 2024, 625,
DOI: 10.1038/s41586-023-06826-7

A Primer on 2D Descriptors in Selectivity Modeling for Asymmetric Catalysis
P. Sidorov, N. Tsuji, Chem. Eur. J., 2023, , e202302837
DOI: 10.1002/chem.202302837
A Catalytic Asymmetric Hydrolactonization
R. Maji, S. Ghosh, O. Grossmann, P. L. Zhang, M. Leutzsch, N. Tsuji, B. List, J. Am. Chem. Soc., 2023, 145, 16, 8788–8793
DOI: 10.1021/jacs.3c01404
Organocatalytic DYKAT of Si-Stereogenic Silanes
H. Zhou, R. Properzi, M. Leutzsch, P. Belanzoni, G. Bistoni, N. Tsuji, J. T. Han, C. D. Zhu, B. List, J. Am. Chem. Soc., 2023, 145, 9, 4994–5000
DOI: 10.1021/jacs.3c00858
Predicting Highly Enantioselective Catalysts Using Tunable Fragment Descriptors
N. Tsuji, P. Sidorov, C. D. Zhu, Y. Nagata, T. Gimadiev, A. Varnek, B. List, Angew. Chem., Int. Ed., 2023, e202218659,
DOI: 10.1002/anie.202218659

Organocatalytic Asymmetric Synthesis of Si-Stereogenic Silyl Ethers
H. Zhou, J. T. Han, N. Nothling, M. M. Lindner, J. Jenniches, C. Kuhn, N. Tsuji, L. Zhang, B. List, J. Am. Chem. Soc., 2022, 144, 10156-10161
DOI: 10.1021/jacs.2c04261

Confinement-Controlled, Either Syn- or Anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
T. Amatov, N. Tsuji, R. Maji, L. Schreyer, H. Zhou, M. Leutzsch, B. List, J. Am. Chem. Soc., 2021, 143, 14475-14481
DOI: 10.1021/jacs.1c07447
Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles
P. L. Zhang, N. Tsuji, J. Ouyang, B. List, J. Am. Chem. Soc., 2021, 143, 675-680
DOI: 10.1021/jacs.0c12042