GAO, Pan

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GAO, Pan
Postdoctoral Fellow

gaopanx atmark

ITO, Hajime Group
Principal Investigator
Faculty Members
Postdoctoral Fellows
Research Collaborators
  • KUBO, Shotaro

About the Research

Research Theme

Mechanochemical Synthesis of Organic Molecules


Mechanochemistry, organometallic reagents, zerovalent metal activation

Research Outline

The formation of novel organometallic compounds by the reaction of organic substrates with metal represents a powerful tool for the synthetic chemist. However, conventional solution-based strategies often require pre-activation of metal under harsh conditions. My research is mainly focused on the activation of metal elements through mechanochemical technique and explore their application to organic synthesis.

Representative Research Achievements

  • Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis.
    R. Takahashi, A. Hu, P. Gao, Y. Gao, Y. Pang, T. Seo, S. Maeda, J. Jiang, H. Takaya, K. Kubota, H. Ito. Nature Commun. 2021, 12, 6691.
    DOI: 10.1038/s41467-021-26962-w
  • Enantioselective Copper-Catalysed Defluorosilylation of Trifluoromethylated Alkenes with Silylboronates.
    P. Gao, L. Gao, L. Xi, Z. Zhang, S. Li, Z. Shi. Org. Chem. Front. 2020, 7, 2618.
    DOI: 10.1039/d0qo00773k
  • Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes.
    P. Gao, C. Yuan, Y. Zhao, Z. Shi. Chem. 2018, 4, 2201.
    DOI: 10.1016/j.chempr.2018.07.003
  • Regiocontrolled Direct C-H Arylation of Indoles at the C4 and C5 Positions.
    Y. Yang, P. Gao, Y. Zhao, Z. Shi. Angew. Chem. Int. Ed. 2017, 56, 3966.
    DOI: 10.1002/anie.201612599
  • Iridium(III)-Catalyzed Direct Arylation of C-H Bonds with Diaryliodonium Salts.
    P. Gao, W. Guo, J. Xue, Y. Zhao, Y. Yuan, Y. Xia, Z. Shi. J. Am. Chem. Soc. 2015, 137, 12231.
    DOI: 10.1021/jacs.5b06758

Related Research



  • Mechanochemical Protocol Facilitates the Generation of Arylmanganese Nucleophiles from Unactivated Manganese Metal
    R. Takahashi, P. Gao, K. Kubota, H. Ito, Chem. Sci., 2022, ,
    DOI: 10.1039/d2sc05468j
  • Mechanochemically Generated Calcium-Based Heavy Grignard Reagents and Their Application to Carbon-Carbon Bond-Forming Reactions
    P. Gao, J. L. Jiang, S. Maeda, K. Kubota, H. Ito, Angew. Chem., Int. Ed., 2022, ,
    DOI: 10.1002/anie.202207118