About the Research
Development of new reactions of small molecules with various elements
Our research group has three main topics. The first is the development of new reactions for organic synthesis using copper, boron, and other organo-metallic compounds. The second is the development of new materials that show interesting optical properties in response to mechanical stress such as grinding. And the third topic is mechano-chemical synthesis. This solvent-free approach promises to be more efficient and environmentally friendly than current light-activated reaction mechanisms.
Calculations constitute an increasingly important technology for the development of new chemical reactions, because experimental chemists have so far relied mainly on experimental screening or serendipity. But computational methods, especially the AFIR method, can predict new reactions and thus guide our search.
The Researcher’s Perspective
Whenever we come across an interesting, new phenomenon, we develop new projects. This is to the benefit of our students, who within their studies can successfully complete sometimes several projects. I am very lucky to be surrounded by excellent colleagues, so we are discovering many exciting things every day!
Representative Research Achievements
- Reversible Mechanochromic Luminescence of (C6F5Au)2(μ-1,4-diisocyanobenzene)
H. Ito, T. Saito, N. Oshima, N. Kitamura, S. Ishizaka, Y. Hinatsu, M. Wakeshima, M. Kato, K. Tsuge, M. Sawamura, J. Am. Chem. Soc., 2008, 130, 10044–10045
DOI : 10.1021/ja8019356
- A Screening Approach for the Discovery of Mechanochromic Gold(I) Isocyanide Complexes with Crystal-to-Crystal Phase Transitions
T. Seki, Y. Takamatsu, H. Ito, J. Am. Chem. Soc., 2016, 138, 6252–6260
DOI : 10.1021/jacs.6b02409
- Mechanochromic Luminescence Based on Crystal-to-Crystal Transformation Mediated by a Transient Amorphous State
S. Yagai, T. Seki, H. Aonuma, K. Kawaguchi, T. Karatsu, T. Okura, A. Sakon, H. Uekusa, H. Ito, Chem. Mater., 2016, 28, 234–241
DOI : 10.1021/acs.chemmater.5b03932
- Boration of an α,β-enone Using a Diboron Promoted by a Copper(I)-Phosphine Mixture Catalyst
H. Ito, H. Yamanaka, J. Tateiwa, A. Hosomi, Tetrahedron Lett., 2000, 41, 6821–6825
DOI : 10.1021/om800946k
- Copper-Catalyzed Enantioselective Substitution of Allylic Carbonates with Diboron: An Efficient Route to Optically Active alpha-Chiral Allylboronates
H. Ito, S. Ito, Y. Sasaki, K. Matsuura, M. Sawamura, J. Am. Chem. Soc., 2007, 129, 14856–14857
DOI : 10.1021/ja076634o