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Specially Appointed Assistant Professor
Mita Group (Maeda-ERATO)

About the Research

Research Theme

Methodology Development Driven by AFIR


Synthetic Organic chemistry, Organometallic Chemistry, Computational Chemistry, Biofunctional Chemistry, Artificial Metalloenzyme
Research History

See my CV.

Representative Research Achievements

  • Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics
    S. R. Mangaonkar, H. Hayashi, H. Takano, W. Kanna, S. Maeda, T. Mita, ACS Catal. 2023, 13, 2482-2488.
    DOI: 10.1021/acscatal.2c06192
  • Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction
    Y. Harabuchi, H. Hayashi, H. Takano, T. Mita, S. Maeda, Angew. Chem., Int. Ed. 2023, 62, e202211936.
    DOI: 10.1002/anie.202211936
  • In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines
    H. Hayashi, H. Katsuyama, H. Takano, Y. Harabuchi, S. Maeda, T. Mita, Nat. Synth. 2022, 1, 804.
    DOI: 10.1038/s44160-022-00128-y
  • Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Application
    H. Hayashi, H. Takano, H. Katsuyama, Y. Harabuchi, S. Maeda, T. Mita, Chem. Eur. J. 2021, 27, 10040.
    DOI: 10.1002/chem.202100812
  • Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols
    H. Hayashi, T. Ueno, C. Kim, T. Uchida, Org. Lett. 2020, 22, 1469.
    DOI: 10.1021/acs.orglett.0c00048
  • Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor
    P. Dydio, H. M. Key, H. Hayashi, D. S. Clark, J. F. Hartwig, J. Am. Chem. Soc. 2017, 139, 1750.
    DOI: 10.1021/jacs.6b11410
  • High-Turnover Hypoiodite Catalysis for Asymmetric Synthesis of Tocopherols
    M. Uyanik, H. Hayashi, K. Ishihara, Science 2014, 345, 291.
    DOI: 10.1126/science.1254976

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