HAYASHI, Hiroki

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HAYASHI, Hiroki
Specially Appointed Associate Professor
Director's Discretionary Unit
Mita Group (Maeda-ERATO)

About the Research

Research Theme

Methodology Development Driven by AFIR

Keyword

Synthetic Organic chemistry, Organometallic Chemistry, Computational Chemistry, Biofunctional Chemistry, Artificial Metalloenzyme
Research History

See my CV.

Representative Research Achievements

  • γ‑Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion
    S. R. Mangaonkar, H. Hayashi, W. Kanna, S. Debbarma, Y. Harabuchi, S. Maeda, T. Mita, Precis. Chem. 2024, 2, DOI: 10.1021/prechem.3c00117.
    DOI:10.1021/prechem.3c00117
  • Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies
    H. Hayashi, S. Maeda, T. Mita, Chem. Sci. 2023, 14, 11601-11616.
    DOI: 10.1039/D3SC03319H
  • Revisiting the Electrochemical Carboxylation of Naphthalene with CO2: Selective Monocarboxylation of 2-Substituted Naphthalenes
    V. K. Rawat, H. Hayashi, H. Katsuyama, S. R. Mangaonkar, T. Mita, Org. Lett. 2023, 25, 4231-4235.
    DOI: 10.1021/acs.orglett.3c01033
  • Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics
    S. R. Mangaonkar, H. Hayashi, H. Takano, W. Kanna, S. Maeda, T. Mita, ACS Catal. 2023, 13, 2482-2488.
    DOI: 10.1021/acscatal.2c06192
  • Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction
    Y. Harabuchi, H. Hayashi, H. Takano, T. Mita, S. Maeda, Angew. Chem., Int. Ed. 2023, 62, e202211936.
    DOI: 10.1002/anie.202211936
  • In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines
    H. Hayashi, H. Katsuyama, H. Takano, Y. Harabuchi, S. Maeda, T. Mita, Nat. Synth. 2022, 1, 804.
    DOI: 10.1038/s44160-022-00128-y
  • Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Application
    H. Hayashi, H. Takano, H. Katsuyama, Y. Harabuchi, S. Maeda, T. Mita, Chem. Eur. J. 2021, 27, 10040.
    DOI: 10.1002/chem.202100812
  • Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols
    H. Hayashi, T. Ueno, C. Kim, T. Uchida, Org. Lett. 2020, 22, 1469.
    DOI: 10.1021/acs.orglett.0c00048
  • Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor
    P. Dydio, H. M. Key, H. Hayashi, D. S. Clark, J. F. Hartwig, J. Am. Chem. Soc. 2017, 139, 1750.
    DOI: 10.1021/jacs.6b11410
  • High-Turnover Hypoiodite Catalysis for Asymmetric Synthesis of Tocopherols
    M. Uyanik, H. Hayashi, K. Ishihara, Science 2014, 345, 291.
    DOI: 10.1126/science.1254976

Related Research

Publications

2023

  • Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies
    H. Hayashi, S. Maeda, T. Mita, Chem. Sci., 2023, 14, 11601-11616
    DOI: 10.1039/d3sc03319H
  • Frontispiece: Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands
    H. Takano, H. Katsuyama, H. Hayashi, M. Harukawa, M. Tsurui, S. Shoji, Y. Hasegawa, S. Maeda, T. Mita, Angew. Chem., Int. Ed., 2023, 62,
    DOI: 10.1002/anie.202382362
  • Toward Ab Initio Reaction Discovery Using the Artificial Force Induced Reaction Method
    S. Maeda, Y. Harabuchi, H. Hayashi, T. Mita, Annual Review of Physical Chemistry, 2023, 74, 287-311
    DOI: 10.1146/annurev-physchem-102822-101025
  • Synthesis of Bicyclo [1.1.1] Pentane (BCP)-Based Straight-Shaped Diphosphine Ligands
    H. Takano, H. Katsuyama, H. Hayashi, M. Harukawa, M. Tsurui, S. Shoji, Y. Hasegawa, S. Maeda, T. Mita, Angew. Chem., Int. Ed., 2023, ,
    DOI: 10.1002/anie.202303435
  • Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics
    S. R. Mangaonkar, H. Hayashi, H. Takano, W. Kanna, S. Maeda, T. Mita, Acs Catalysis, 2023, 13, 4, 2482-2488
    DOI: 10.1021/acscatal.2c06192

2022

  • Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets
    T. Mita, H. Takano, H. Hayashi, W. Kanna, Y. Harabuchi, K. N. Houk, S. Maeda, J. Am. Chem. Soc., 2022, 144, 50, 22985–23000
    DOI: 10.1021/jacs.2c09830
  • Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction
    Y. Harabuchi, H. Hayashi, H. Takano, T. Mita, S. Maeda, Angew. Chem., Int. Ed., 2022, ,
    DOI: 10.1002/anie.202211936