林 裕樹

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林 裕樹
特任准教授
拠点長裁量ユニット
美多グループ (前田-ERATO)

研究紹介

研究テーマ

AFIR法による新反応開発

キーワード

有機合成化学、有機金属化学、計算科学、生体機能関連化学、人工金属酵素
経歴

経歴（Curriculum Vitae）を参照願います。

関連情報

反応経路自動探索が見いだした新規3成分複素環構築法

酸化反応条件で抗酸化物質を効率的につくる

Reaxys Prize 2015 ファイナリスト発表!

第37回若い世代の特別講演会

代表的な研究成果

  • Photoredox-Catalyst-Free Carboxylation of Unactivated Alkenes in DMSO: Synthesis of Polycyclic Indole Derivatives and Aliphatic Acids
    S. Debbarma, H. Hayashi, Y. Ueno, W. Kanna, K. Tanaka, III, T. Mita, Org. Lett. 2024, 26, 10897-10902.
    DOI: 10.1021/acs.orglett.4c04051
  • γ‑Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion
    S. R. Mangaonkar, H. Hayashi, W. Kanna, S. Debbarma, Y. Harabuchi, S. Maeda, T. Mita, Precis. Chem. 2024, 2, 88-95.
    DOI: 10.1021/prechem.3c00117
  • Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies
    H. Hayashi, S. Maeda, T. Mita, Chem. Sci. 2023, 14, 11601-11616.
    DOI: 10.1039/D3SC03319H
  • Revisiting the Electrochemical Carboxylation of Naphthalene with CO2: Selective Monocarboxylation of 2-Substituted Naphthalenes
    V. K. Rawat, H. Hayashi, H. Katsuyama, S. R. Mangaonkar, T. Mita, Org. Lett. 2023, 25, 4231-4235.
    DOI: 10.1021/acs.orglett.3c01033
  • Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics
    S. R. Mangaonkar, H. Hayashi, H. Takano, W. Kanna, S. Maeda, T. Mita, ACS Catal. 2023, 13, 2482-2488.
    DOI: 10.1021/acscatal.2c06192
  • Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction
    Y. Harabuchi, H. Hayashi, H. Takano, T. Mita, S. Maeda, Angew. Chem., Int. Ed. 2023, 62, e202211936.
    DOI: 10.1002/anie.202211936
  • In Silico Reaction Screening with Difluorocarbene for N-Difluoroalkylative Dearomatization of Pyridines
    H. Hayashi, H. Katsuyama, H. Takano, Y. Harabuchi, S. Maeda, T. Mita, Nat. Synth. 2022, 1, 804.
    DOI: 10.1038/s44160-022-00128-y
  • Synthesis of Difluoroglycine Derivatives from Amines, Difluorocarbene, and CO2: Computational Design, Scope, and Application
    H. Hayashi, H. Takano, H. Katsuyama, Y. Harabuchi, S. Maeda, T. Mita, Chem. Eur. J. 2021, 27, 10040.
    DOI: 10.1002/chem.202100812
  • Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols
    H. Hayashi, T. Ueno, C. Kim, T. Uchida, Org. Lett. 2020, 22, 1469.
    DOI: 10.1021/acs.orglett.0c00048
  • Chemoselective, Enzymatic C–H Bond Amination Catalyzed by a Cytochrome P450 Containing an Ir(Me)-PIX Cofactor
    P. Dydio, H. M. Key, H. Hayashi, D. S. Clark, J. F. Hartwig, J. Am. Chem. Soc. 2017, 139, 1750.
    DOI: 10.1021/jacs.6b11410
  • High-Turnover Hypoiodite Catalysis for Asymmetric Synthesis of Tocopherols
    M. Uyanik, H. Hayashi, K. Ishihara, Science 2014, 345, 291.
    DOI: 10.1126/science.1254976

関連する研究記事

業績一覧

2025年

  • Computationally Guided Development of an Alkene Aminocarboxylation with CO2: Synthesis of a β-Amino Acid Derivative
    W. Kanna, Y. Harabuchi, K. I. Tanaka, H. Hayashi, H. Takano, T. Kozuka, H. Sakurai, N. Mase, S. Maeda, T. Mita, Acs Catalysis, 2025, 15, 12180-12191
    DOI: 10.1021/acscatal.5c03580
  • Direct Generation of Carboxyl Radicals from Carboxylic Acids Catalyzed by Photoactivated Ketones
    K. Yamashita, H. Sano, Y. Goto, H. Hayashi, Y. Hamashima, J. Am. Chem. Soc., 2025, ,
    DOI: 10.1021/jacs.5c04571

2024年

  • Photoredox-Catalyst-Free Carboxylation of Unactivated Alkenes in DMSO: Synthesis of Polycyclic Indole Derivatives and Aliphatic Acids
    S. Debbarma, H. Hayashi, Y. Ueno, W. Kanna, K. Tanaka, III, T. Mita, Org. Lett., 2024, ,
    DOI: 10.1021/acs.orglett.4c04051
  • Strain-Releasing Ring-Opening Diphosphinations for the Synthesis of Diphosphine Ligands with Cyclic Backbones
    C. Krishnan, H. Takano, H. Katsuyama, W. Kanna, H. Hayashi, T. Mita, Jacs Au, 2024, 4, 10, 3777–3787
    DOI: 10.1021/jacsau.4c00347
  • Trans-Selective Carboxylative Cyclization of 1,6-Dienes Using the CO2 Radical Anion
    Y. Song, H. Hayashi, S. Mangaonkar, T. Mita, Chem. Lett., 2024, 53, 8, upae149
    DOI: 10.1093/chemle/upae149
  • γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO2 Radical Anion
    S. Mangaonkar, H. Hayashi, W. Kanna, S. Debbarma, Y. Harabuchi, S. Maeda, T. Mita, Precis. Chem., 2024, 2, 3, 88-95
    DOI: 10.1021/prechem.3c00117

2023年

  • Quantum Chemical Calculations for Reaction Prediction in the Development of Synthetic Methodologies
    H. Hayashi, S. Maeda, T. Mita, Chem. Sci., 2023, 14, 11601-11616
    DOI: 10.1039/d3sc03319H
  • Frontispiece: Synthesis of Bicyclo[1.1.1]pentane (BCP)-Based Straight-Shaped Diphosphine Ligands
    H. Takano, H. Katsuyama, H. Hayashi, M. Harukawa, M. Tsurui, S. Shoji, Y. Hasegawa, S. Maeda, T. Mita, Angew. Chem., Int. Ed., 2023, 62,
    DOI: 10.1002/anie.202382362
  • Toward Ab Initio Reaction Discovery Using the Artificial Force Induced Reaction Method
    S. Maeda, Y. Harabuchi, H. Hayashi, T. Mita, Annual Review of Physical Chemistry, 2023, 74, 287-311
    DOI: 10.1146/annurev-physchem-102822-101025
  • Synthesis of Bicyclo [1.1.1] Pentane (BCP)-Based Straight-Shaped Diphosphine Ligands
    H. Takano, H. Katsuyama, H. Hayashi, M. Harukawa, M. Tsurui, S. Shoji, Y. Hasegawa, S. Maeda, T. Mita, Angew. Chem., Int. Ed., 2023, ,
    DOI: 10.1002/anie.202303435
  • Photoredox/HAT-Catalyzed Dearomative Nucleophilic Addition of the CO2 Radical Anion to (Hetero)Aromatics
    S. R. Mangaonkar, H. Hayashi, H. Takano, W. Kanna, S. Maeda, T. Mita, Acs Catalysis, 2023, 13, 4, 2482-2488
    DOI: 10.1021/acscatal.2c06192

2022年

  • Prediction of High-Yielding Single-Step or Cascade Pericyclic Reactions for the Synthesis of Complex Synthetic Targets
    T. Mita, H. Takano, H. Hayashi, W. Kanna, Y. Harabuchi, K. N. Houk, S. Maeda, J. Am. Chem. Soc., 2022, 144, 50, 22985–23000
    DOI: 10.1021/jacs.2c09830
  • Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction
    Y. Harabuchi, H. Hayashi, H. Takano, T. Mita, S. Maeda, Angew. Chem., Int. Ed., 2022, ,
    DOI: 10.1002/anie.202211936