INOKUMA, Yasuhide

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INOKUMA, Yasuhide
Principal Investigator, Professor
Hokkaido University
Research Areas
Organic Chemistry, Supramolecular Chemistry
Related Website

inokuma atmark

INOKUMA, Yasuhide Group
Principal Investigator
  • thumbnail image
    INOKUMA, Yasuhide
Faculty Members
Postdoctoral Fellows
Research Collaborators

About the Research

Research Theme

Development of functional materials from aliphatic polyketones as 'carbonyl ropes'


carbonyl compounds, crystallography

Research Outline

Since function is largely determined by shape, my goal is to create molecules that can be shaped with ease. Inspired by clay ropes used in pottery, I employ mainly polyketone polymers of determinable lengths whose flexible nature allows for the creation of any imaginable molecular shape. In addition, the great wealth of knowledge on carbonyl group reactions that can act on these polyketones enables us to introduce many desirable modifications into our “molecular ropes”.

ICReDD is a wonderful opportunity to find applications for these molecules, and to predict useful shapes and modifications, through the collaboration with information scientists and computational chemists.

The Researcher’s Perspective

Watching people grow to become better and better than myself is a source of much fun to me. Therefore, I encourage my students to discuss and think for themselves, and doing science is a tool for that. But if that personal growth can also result in new materials or new chemical reactions, that’s even better!

For details on MANABIYA course topics, please follow this link. To learn more about MANABIYA in general, please click here.

Representative Research Achievements

  • Control over Coordination Self-Assembly of Flexible, Multidentate Ligands by Stepwise Metal Coordination of Isopyrazole Subunits
    Y. Ashida, Y. Manabe, S. Yoshioka, T. Yoneda, Y. Inokuma, Dalton Trans., 2019, 48, 818-822
    DOI : 10.1039/C8DT04935A
  • Oligoacetylacetones as Shapable Carbon Chains and Their Transformation to Oligoimines for Construction of Metal-organic Architectures
    M. Uesaka, Y. Saito, S. Yoshioka, Y. Domoto, M. Fujita, Y. Inokuma, Comms. Chem., 2018, 1, article number 23
    DOI : 10.1038/s42004-018-0021-3
  • Bioinspired Synthesis of Pentalene-based Chromophores from an Oligoketone Chain
    Y. Saito, M. Higuchi, S. Yoshioka, H. Senboku, Y. Inokuma, Chem. Commun., 2018, 54, 6788-6791
    DOI : 10.1039/C8CC02379D
  • Preparation and Guest-Uptake Protocol for a Porous Complex Useful for ‘Crystal-free’ Crystallography
    Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, M. Fujita, Nat. Protocols, 2014, 9, 246-252
    DOI : 10.1038/nprot.2014.007
  • X-ray Analysis on the Nanogram to Microgram Scale Using Porous Complexes
    Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, Y. Hitora, K. Takada, S. Matsunaga, K. Rissanen, M. Fujita, Nature, 2013, 495, 461-466
    DOI : 10.1038/nature11990

Related Research



  • Implementation of Highly Crystalline Polyketones as Solid Polymer Electrolytes in High-Temperature Lithium Metal Batteries
    R. Andersson, I. L. Johansson, K. I. Shivakumar, G. Hern, Y. Inokuma, J. Mindemark, Solid State Ionics, 2024, 410,
    DOI: 10.1016/j.ssi.2024.116542
  • Strain-Based Design, Direct Macrocyclization, and Metal Complexation of Thiazole-Containing Calix[3]pyrrole Analogues
    K. Watanabe, K. Shibata, T. Ichino, Y. Ide, T. Yoneda, S. Maeda, Y. Inokuma, Inorganic Chemistry Frontiers, 2024, ,
    DOI: 10.1039/d4qi00684d
  • Contracted Porphyrins and Calixpyrroles: Synthetic Challenges and Ring-Contraction Effects
    K. Watanabe, N. N. Pati, Y. Inokuma, Chem. Sci., 2024, ,
    DOI: 10.1039/d4sc02028f
  • Drug-Drug Conjugates of MEK and Akt Inhibitors for RAS-Mutant Cancers
    H. Fujita, S. Arai, H. Arakawa, K. Hamamoto, T. Kato, T. Arai, N. Nitta, K. Hotta, N. Hosokawa, T. Ohbayashi, C. Takahashi, Y. Inokuma, I. Tamai, S. Yano, M. Kunishima, Y. Watanabe, Bioorganic & Medicinal Chemistry, 2024, 102,
    DOI: 10.1016/j.bmc.2024.117674


  • Machine Learning-Based Analysis of Molar and Enantiomeric Ratios and Reaction Yields Using Images of Solid Mixtures
    Y. Ide, H. Shirakura, T. Sano, M. Murugavel, Y. Inaba, S. Hu, I. Takigawa, Y. Inokuma, Industrial & Engineering Chemistry Research, 2023, 62, 35, 13790–13798
    DOI: 10.1021/acs.iecr.3c01882
  • Identifying High-Grade Serous Ovarian Carcinoma-Specific Extracellular Vesicles by Polyketone-Coated Nanowires
    A. Yokoi, M. Ukai, T. Yasui, Y. Inokuma, K. Hyeon-Deuk, J. Matsuzaki, K. Yoshida, M. Kitagawa, K. Chattrairat, M. Iida, T. Shimada, Y. Manabe, I. Y. Chang, E. Asano-Inami, Y. Koya, A. Nawa, K. Nakamura, T. Kiyono, T. Kato, A. Hirakawa, Y. Yoshioka, T. Ochiya, T. Hasegawa, Y. Baba, Y. Yamamoto, H. Kajiyama, Science Advances, 2023, 9, 27
    DOI: 10.1126/sciadv.ade6958
  • The Geometry of Calix[3]pyrrole and the Formation of the Calix[3]pyrrole·F- Complex in Solution
    R. Saha, J. Pirillo, Y. Ide, Y. Inokuma, Y. Hijikata, Theoretical Chemistry Accounts, 2023, 142, article number 50(page 13)
    DOI: 10.1007/s00214-023-02982-1
  • Chain-Length-Dependent Hydrogen-Bonded Self-Assembly of Terminally Functionalized Discrete Polyketones
    Kilingaru I. Shivakumar, Yumehiro Manabe, Tomoki Yoneda, Yuki Ide, Yasuhide Inokuma, Precis. Chem., 2023, 1, 34–39
    DOI: 10.1021/prechem.3c00025
  • Toward Calix[2]-Type Macrocycles: Synthesis and Structural Analysis of Cyclic Tetraketone and Highly Strained Furanophane
    T. Sano, Y. H. Sun, T. Mukai, Y. Inaba, T. Yoneda, Y. Ide, J. Pirillo, Y. Hijikata, Y. Inokuma, Journal of Porphyrins and Phthalocyanines, 2023, 27, 1067–1073
    DOI: 10.1142/s1088424623500189
  • Chiral Calix[3]pyrrole Derivatives: Synthesis, Racemization Kinetics, and Ring Expansion to Calix[9] - and Calix[12]pyrrole Analogues
    Y. Inaba, J. Yang, Y. Kakibayashi, T. Yoneda, Y. Ide, Y. Hijikata, J. Pirillo, R. Saha, J. L. Sessler, Y. Inokuma, Angew. Chem., Int. Ed., 2023, 62, e202301460 (page 6)
    DOI: 10.1002/anie.202301460
  • Absorption Spectra of Calix[3]pyrrole Analogs as Probes for Contracted Macrocycles
    K. Watanabe, R. Saha, Y. Inaba, Y. Manabe, T. Yoneda, Y. Ide, Y. Hijikata, Y. Inokuma, Journal of Porphyrins and Phthalocyanines, 2023, 27, 157-163
    DOI: 10.1142/s1088424622500754


  • Determination of the Critical Chain Length for Macromolecular Crystallization Using Structurally Flexible Polyketones
    Y. Ide, Y. Manabe, Y. Inaba, Y. Kinoshita, J. Pirillo, Y. Hijikata, T. Yoneda, K. I. Shivakumar, S. Tanaka, H. Asakawa, Y. Inokuma, Chem. Sci., 2022, 13, 9848-9854
    DOI: 10.1039/d2sc03083g
  • Strain-Induced Ring Expansion Reactions of Calix 3 Pyrrole-Related Macrocycles
    Y. Inaba, Y. Kakibayashi, Y. Ide, J. Pirillo, Y. Hijikata, T. Yoneda, Y. Inokuma, Chem. Eur. J., 2022, 28, e202200056
    DOI: 10.1002/chem.202200056
  • Alkali Metal Ion Binding Using Cyclic Polyketones
    N. Ozawa, K. I. Shivakumar, M. Murugavel, Y. Inaba, T. Yoneda, Y. Ide, J. Pirillo, Y. Hijikata, Y. Inokuma, Chem. Commun., 2022, 58, 2971-2974
    DOI: 10.1039/d2cc00361a


  • Polyketone-Based Molecular Ropes as Versatile Components for Functional Materials
    Y. Inokuma, Y. Inaba, Bulletin of the Chemical Society of Japan, 2021, 94, 2187-2194
    DOI: 10.1246/bcsj.20210223
  • Hybrid Eu-III Coordination Luminophore Standing on Two Legs on Silica Nanoparticles for Enhanced Luminescence
    T. Zhang, Y. Kitagawa, R. Moriake, P. P. F. da Rosa, M. J. Islam, T. Yoneda, Y. Inokuma, K. Fushimi, Y. Hasegawa, Chem. Eur. J., 2021, 27, 14438-14443
    DOI: 10.1002/chem.202102156
  • Isopyrazole-Masked Tetraketone: Tautomerism and Functionalization for Fluorescent Metal Ligands
    H. Shirakura, Y. Manabe, C. Kasai, Y. Inaba, M. Tsurui, Y. Kitagawa, Y. Hasegawa, T. Yoneda, Y. Ide, Y. Inokuma, European Journal of Organic Chemistry, 2021, 2021, 4345-4349
    DOI: 10.1002/ejoc.202100784
  • Calix 3 Pyrrole: A Missing Link in Porphyrin-Related Chemistry
    Y. Inaba, Y. Nomata, Y. Ide, J. Pirillo, Y. Hijikata, T. Yoneda, A. Osuka, J. L. Sessler, Y. Inokuma, J. Am. Chem. Soc., 2021, 143, 12355-12360
    DOI: 10.1021/jacs.1c06331
  • Insoluble Pi-Conjugated Polyimine as an Organic Adsorbent for Group 10 Metal Ions
    H. Shirakura, Y. Hijikata, J. Pirillo, T. Yoneda, Y. Manabe, M. Murugavel, Y. Ide, Y. Inokuma, European Journal of Inorganic Chemistry, 2021, , 1705-1708
    DOI: 10.1002/ejic.202100172


  • Splitting and Reorientation of Pi-Conjugation by an Unprecedented Photo-Rearrangement Reaction
    Inaba, Y, Yoneda, T, Kitagawa, Y, Miyata, K, Hasegawa, Y, Inokuma, Y, Chem. Commun., 2020, 56, 348-351
    DOI: 10.1039/c9cc09062b
  • Spirosilicate Dimers of a Bowl-Shaped Diol Generated by Intramolecular Cyclization of an Aliphatic Tetraketone Chain
    Y. Inaba, Y. Inokuma, Chem. Lett., 2020, 49, 882-884
    DOI: 10.1246/cl.200299
  • Aliphatic Polyketones as Classic yet New Molecular Ropes for Structural Diversity in Organic Synthesis
    Y. Inokuma, T. Yoneda, Y. Ide, S. Yoshioka, Chem. Commun., 2020, 56, 9079-9093
    DOI: 10.1039/d0cc02977g
  • Modular Synthesis of Oligoacetylacetones via Site-Selective Silylation of Acetylacetone Derivatives
    P. Sarkar, Y. Inaba, H. Shirakura, T. Yoneda, Y. Inokuma, Org. Biomol. Chem., 2020, 18, 3297-3302
    DOI: 10.1039/d0ob00501k
  • Chiral Monolayers with Achiral Tetrapod Molecules on Highly Oriented Pyrolytic Graphite
    H. Asakawa, S. Matsui, Q. T. Trinh, H. Hirao, Y. Inokuma, T. Ogoshi, S. Tanaka, K. Komatsu, A. Ohta, T. Asakawa, T. Fukuma, J. Phys. Chem. C, 2020, 124, 7760-7767
    DOI: 10.1021/acs.jpcc.9b11246
  • Supramolecular Conformational Control of Aliphatic Oligoketones by Rotaxane Formation
    Y. Manabe, K. Wada, Y. Baba, T. Yoneda, T. Ogoshi, Y. Inokuma, Org. Lett., 2020, 22, 3224-3228
    DOI: 10.1021/acs.orglett.0c01010
  • Luminescent Coordination Polymers Constructed from a Flexible, Tetradentate Diisopyrazole Ligand and Copper(I) Halides
    T. Yoneda, C. Kasai, Y. Manabe, M. Tsurui, Y. Kitagawa, Y. Hasegawa, P. Sarkar, Y. Inokuma, Chem. Asian J., 2020, 15, 601-605
    DOI: 10.1002/asia.201901682


  • Control over Coordination Self-Assembly of Flexible, Multidentate Ligands by Stepwise Metal Coordination of Isopyrazole Subunits
    Y. Ashida, Y. Manabe, S. Yoshioka, T. Yoneda, Y. Inokuma, Dalton Trans., 2019, 48, 818-822
    DOI: 10.1039/c8dt04935a
  • Aliphatic Polyketones as Shapable Molecular Chains
    Y. Inokuma, J. Syn. Org. Chem. Jpn., 2019, 77, 1078-1085
    DOI: 10.5059/yukigoseikyokaishi.77.1078
  • Two-Step Transformation of Aliphatic Polyketones into π-Conjugated Polyimines
    Y. Manabe, M. Uesaka, T. Yoneda, Y. Inokuma, J. Org. Chem., 2019, 84, 9957-9964
    DOI: 10.1021/acs.joc.9b01119