About the Research
Development of functional materials from aliphatic polyketones as 'carbonyl ropes'
Since function is largely determined by shape, my goal is to create molecules that can be shaped with ease. Inspired by clay ropes used in pottery, I employ mainly polyketone polymers of determinable lengths whose flexible nature allows for the creation of any imaginable molecular shape. In addition, the great wealth of knowledge on carbonyl group reactions that can act on these polyketones enables us to introduce many desirable modifications into our “molecular ropes”.
ICReDD is a wonderful opportunity to find applications for these molecules, and to predict useful shapes and modifications, through the collaboration with information scientists and computational chemists.
The Researcher’s Perspective
Watching people grow to become better and better than myself is a source of much fun to me. Therefore, I encourage my students to discuss and think for themselves, and doing science is a tool for that. But if that personal growth can also result in new materials or new chemical reactions, that’s even better!
Representative Research Achievements
- Control over Coordination Self-Assembly of Flexible, Multidentate Ligands by Stepwise Metal Coordination of Isopyrazole Subunits
Y. Ashida, Y. Manabe, S. Yoshioka, T. Yoneda, Y. Inokuma, Dalton Trans., 2019, 48, 818-822
DOI : 10.1039/C8DT04935A
- Oligoacetylacetones as Shapable Carbon Chains and Their Transformation to Oligoimines for Construction of Metal-organic Architectures
M. Uesaka, Y. Saito, S. Yoshioka, Y. Domoto, M. Fujita, Y. Inokuma, Comms. Chem., 2018, 1, article number 23
DOI : 10.1038/s42004-018-0021-3
- Bioinspired Synthesis of Pentalene-based Chromophores from an Oligoketone Chain
Y. Saito, M. Higuchi, S. Yoshioka, H. Senboku, Y. Inokuma, Chem. Commun., 2018, 54, 6788-6791
DOI : 10.1039/C8CC02379D
- Preparation and Guest-Uptake Protocol for a Porous Complex Useful for ‘Crystal-free’ Crystallography
Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, M. Fujita, Nat. Protocols, 2014, 9, 246-252
DOI : 10.1038/nprot.2014.007
- X-ray Analysis on the Nanogram to Microgram Scale Using Porous Complexes
Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, Y. Hitora, K. Takada, S. Matsunaga, K. Rissanen, M. Fujita, Nature, 2013, 495, 461-466
DOI : 10.1038/nature11990
- Press Release Surpassing the human eye: machine learning image analysis rapidly determines chemical mixture composition
- Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires
- Windmill-shaped, calixpyrrole analogue discovered via ring expansion from chiral calixpyrrole analogue
- Determining Critical Chain Length for Macromolecular Crystallization of Polyketones
- Cyclic polyketones shown to act as ‘traps’ for alkali metal ions and catalyze halogen exchange reactions
- Unlocking the Mysteries Behind the Synthesis of the “Pigments of Life”
- A fluorescent metal-ion detector generated from a ‘masked’ tetraketone
- Molecular ropes to allow more intuitive material design