猪熊 泰英

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猪熊 泰英
主任研究者, 教授
北海道大学
研究分野
有機化学, 超分子化学
関連ウェブサイト
連絡先

inokuma atmark eng.hokudai.ac.jp

猪熊 泰英 グループ
主任研究者
  • thumbnail image
    猪熊 泰英
教員
博士研究員
研究協力者

研究紹介

研究テーマ

脂肪族ポリカルボニル化合物「カルボニルひも」を用いた機能性分子の開拓

キーワード

カルボニル化合物, 結晶構造解析

研究概要

物質の機能は、主にその物質を構成する分子の構造によって決まります。様々な機能を自在に生み出すために、構造を容易に制御できる分子を創ることが私の目標です。柔軟な粘土のひもを駆使して土器を創り出す手法にヒントを得て、私の研究ではポリケトンと呼ばれる「分子ひも」を合成し分子の構造制御に挑んでいます。ポリケトンには粘土ひもと同様にすぐれた柔軟性と互いにくっつき合う作用があるため、様々な分子形状を創ることがでます。また、ポリケトンを構成するカルボニル基を活用することで「分子ひも」に様々な化学修飾を施すことも可能です。

ICReDDでは情報科学者や計算化学者との共同研究を行っています。これにより、分子ひもで有効な機能を生み出す構造や化学反応を予測したりすることができます。そういった素晴らしい融合研究の場がICReDDなのです。

研究者の思い

研究に携わる人たちが日々成長してゆく姿を見ることが一番の喜びです。そのためには、自分たちで考え議論することが重要だと学生さんたちにはいつも伝えています。科学はあくまで成長を促すツールでしかないのです。彼らが成長することで新しい物質や化学反応の発見繋がるのであれば、研究はさらに楽しいものになるに違いありません。

MANABIYAコースの研修内容はこちらです。MANABIYA全般について詳しく知りたい方は、こちらをクリックしてください。

代表的な研究成果

  • Control over Coordination Self-Assembly of Flexible, Multidentate Ligands by Stepwise Metal Coordination of Isopyrazole Subunits
    Y. Ashida, Y. Manabe, S. Yoshioka, T. Yoneda, Y. Inokuma, Dalton Trans., 2019, 48, 818-822
    DOI : 10.1039/C8DT04935A
  • Oligoacetylacetones as Shapable Carbon Chains and Their Transformation to Oligoimines for Construction of Metal-organic Architectures
    M. Uesaka, Y. Saito, S. Yoshioka, Y. Domoto, M. Fujita, Y. Inokuma, Comms. Chem., 2018, 1, article number 23
    DOI : 10.1038/s42004-018-0021-3
  • Bioinspired Synthesis of Pentalene-based Chromophores from an Oligoketone Chain
    Y. Saito, M. Higuchi, S. Yoshioka, H. Senboku, Y. Inokuma, Chem. Commun., 2018, 54, 6788-6791
    DOI : 10.1039/C8CC02379D
  • Preparation and Guest-Uptake Protocol for a Porous Complex Useful for ‘Crystal-free’ Crystallography
    Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, M. Fujita, Nat. Protocols, 2014, 9, 246-252
    DOI : 10.1038/nprot.2014.007
  • X-ray Analysis on the Nanogram to Microgram Scale Using Porous Complexes
    Y. Inokuma, S. Yoshioka, J. Ariyoshi, T. Arai, Y. Hitora, K. Takada, S. Matsunaga, K. Rissanen, M. Fujita, Nature, 2013, 495, 461-466
    DOI : 10.1038/nature11990

関連する研究記事

業績一覧

2024年

  • Discrete Polyketones: Synthesis, Derivatization, and Potential Applications
    Y. Inokuma, Bulletin of the Chemical Society of Japan, 2024, 97,
    DOI: 10.1093/bulcsj/uoae072
  • Implementation of Highly Crystalline Polyketones as Solid Polymer Electrolytes in High-Temperature Lithium Metal Batteries
    R. Andersson, I. L. Johansson, K. I. Shivakumar, G. Hern, Y. Inokuma, J. Mindemark, Solid State Ionics, 2024, 410,
    DOI: 10.1016/j.ssi.2024.116542
  • Strain-Based Design, Direct Macrocyclization, and Metal Complexation of Thiazole-Containing Calix[3]pyrrole Analogues
    K. Watanabe, K. Shibata, T. Ichino, Y. Ide, T. Yoneda, S. Maeda, Y. Inokuma, Inorganic Chemistry Frontiers, 2024, ,
    DOI: 10.1039/d4qi00684d
  • Contracted Porphyrins and Calixpyrroles: Synthetic Challenges and Ring-Contraction Effects
    K. Watanabe, N. N. Pati, Y. Inokuma, Chem. Sci., 2024, ,
    DOI: 10.1039/d4sc02028f
  • Drug-Drug Conjugates of MEK and Akt Inhibitors for RAS-Mutant Cancers
    H. Fujita, S. Arai, H. Arakawa, K. Hamamoto, T. Kato, T. Arai, N. Nitta, K. Hotta, N. Hosokawa, T. Ohbayashi, C. Takahashi, Y. Inokuma, I. Tamai, S. Yano, M. Kunishima, Y. Watanabe, Bioorganic & Medicinal Chemistry, 2024, 102,
    DOI: 10.1016/j.bmc.2024.117674

2023年

  • Machine Learning-Based Analysis of Molar and Enantiomeric Ratios and Reaction Yields Using Images of Solid Mixtures
    Y. Ide, H. Shirakura, T. Sano, M. Murugavel, Y. Inaba, S. Hu, I. Takigawa, Y. Inokuma, Industrial & Engineering Chemistry Research, 2023, 62, 35, 13790–13798
    DOI: 10.1021/acs.iecr.3c01882
  • Identifying High-Grade Serous Ovarian Carcinoma-Specific Extracellular Vesicles by Polyketone-Coated Nanowires
    A. Yokoi, M. Ukai, T. Yasui, Y. Inokuma, K. Hyeon-Deuk, J. Matsuzaki, K. Yoshida, M. Kitagawa, K. Chattrairat, M. Iida, T. Shimada, Y. Manabe, I. Y. Chang, E. Asano-Inami, Y. Koya, A. Nawa, K. Nakamura, T. Kiyono, T. Kato, A. Hirakawa, Y. Yoshioka, T. Ochiya, T. Hasegawa, Y. Baba, Y. Yamamoto, H. Kajiyama, Science Advances, 2023, 9, 27
    DOI: 10.1126/sciadv.ade6958
  • The Geometry of Calix[3]pyrrole and the Formation of the Calix[3]pyrrole·F- Complex in Solution
    R. Saha, J. Pirillo, Y. Ide, Y. Inokuma, Y. Hijikata, Theoretical Chemistry Accounts, 2023, 142, article number 50(page 13)
    DOI: 10.1007/s00214-023-02982-1
  • Chain-Length-Dependent Hydrogen-Bonded Self-Assembly of Terminally Functionalized Discrete Polyketones
    Kilingaru I. Shivakumar, Yumehiro Manabe, Tomoki Yoneda, Yuki Ide, Yasuhide Inokuma, Precis. Chem., 2023, 1, 34–39
    DOI: 10.1021/prechem.3c00025
  • Toward Calix[2]-Type Macrocycles: Synthesis and Structural Analysis of Cyclic Tetraketone and Highly Strained Furanophane
    T. Sano, Y. H. Sun, T. Mukai, Y. Inaba, T. Yoneda, Y. Ide, J. Pirillo, Y. Hijikata, Y. Inokuma, Journal of Porphyrins and Phthalocyanines, 2023, 27, 1067–1073
    DOI: 10.1142/s1088424623500189
  • Chiral Calix[3]pyrrole Derivatives: Synthesis, Racemization Kinetics, and Ring Expansion to Calix[9] - and Calix[12]pyrrole Analogues
    Y. Inaba, J. Yang, Y. Kakibayashi, T. Yoneda, Y. Ide, Y. Hijikata, J. Pirillo, R. Saha, J. L. Sessler, Y. Inokuma, Angew. Chem., Int. Ed., 2023, 62, e202301460 (page 6)
    DOI: 10.1002/anie.202301460
  • Absorption Spectra of Calix[3]pyrrole Analogs as Probes for Contracted Macrocycles
    K. Watanabe, R. Saha, Y. Inaba, Y. Manabe, T. Yoneda, Y. Ide, Y. Hijikata, Y. Inokuma, Journal of Porphyrins and Phthalocyanines, 2023, 27, 157-163
    DOI: 10.1142/s1088424622500754

2022年

  • Determination of the Critical Chain Length for Macromolecular Crystallization Using Structurally Flexible Polyketones
    Y. Ide, Y. Manabe, Y. Inaba, Y. Kinoshita, J. Pirillo, Y. Hijikata, T. Yoneda, K. I. Shivakumar, S. Tanaka, H. Asakawa, Y. Inokuma, Chem. Sci., 2022, 13, 9848-9854
    DOI: 10.1039/d2sc03083g
  • Strain-Induced Ring Expansion Reactions of Calix 3 Pyrrole-Related Macrocycles
    Y. Inaba, Y. Kakibayashi, Y. Ide, J. Pirillo, Y. Hijikata, T. Yoneda, Y. Inokuma, Chem. Eur. J., 2022, 28, e202200056
    DOI: 10.1002/chem.202200056
  • Alkali Metal Ion Binding Using Cyclic Polyketones
    N. Ozawa, K. I. Shivakumar, M. Murugavel, Y. Inaba, T. Yoneda, Y. Ide, J. Pirillo, Y. Hijikata, Y. Inokuma, Chem. Commun., 2022, 58, 2971-2974
    DOI: 10.1039/d2cc00361a

2021年

  • Polyketone-Based Molecular Ropes as Versatile Components for Functional Materials
    Y. Inokuma, Y. Inaba, Bulletin of the Chemical Society of Japan, 2021, 94, 2187-2194
    DOI: 10.1246/bcsj.20210223
  • Hybrid Eu-III Coordination Luminophore Standing on Two Legs on Silica Nanoparticles for Enhanced Luminescence
    T. Zhang, Y. Kitagawa, R. Moriake, P. P. F. da Rosa, M. J. Islam, T. Yoneda, Y. Inokuma, K. Fushimi, Y. Hasegawa, Chem. Eur. J., 2021, 27, 14438-14443
    DOI: 10.1002/chem.202102156
  • Isopyrazole-Masked Tetraketone: Tautomerism and Functionalization for Fluorescent Metal Ligands
    H. Shirakura, Y. Manabe, C. Kasai, Y. Inaba, M. Tsurui, Y. Kitagawa, Y. Hasegawa, T. Yoneda, Y. Ide, Y. Inokuma, European Journal of Organic Chemistry, 2021, 2021, 4345-4349
    DOI: 10.1002/ejoc.202100784
  • Calix 3 Pyrrole: A Missing Link in Porphyrin-Related Chemistry
    Y. Inaba, Y. Nomata, Y. Ide, J. Pirillo, Y. Hijikata, T. Yoneda, A. Osuka, J. L. Sessler, Y. Inokuma, J. Am. Chem. Soc., 2021, 143, 12355-12360
    DOI: 10.1021/jacs.1c06331
  • Insoluble Pi-Conjugated Polyimine as an Organic Adsorbent for Group 10 Metal Ions
    H. Shirakura, Y. Hijikata, J. Pirillo, T. Yoneda, Y. Manabe, M. Murugavel, Y. Ide, Y. Inokuma, European Journal of Inorganic Chemistry, 2021, , 1705-1708
    DOI: 10.1002/ejic.202100172

2020年

  • Splitting and Reorientation of Pi-Conjugation by an Unprecedented Photo-Rearrangement Reaction
    Inaba, Y, Yoneda, T, Kitagawa, Y, Miyata, K, Hasegawa, Y, Inokuma, Y, Chem. Commun., 2020, 56, 348-351
    DOI: 10.1039/c9cc09062b
  • Spirosilicate Dimers of a Bowl-Shaped Diol Generated by Intramolecular Cyclization of an Aliphatic Tetraketone Chain
    Y. Inaba, Y. Inokuma, Chem. Lett., 2020, 49, 882-884
    DOI: 10.1246/cl.200299
  • Aliphatic Polyketones as Classic yet New Molecular Ropes for Structural Diversity in Organic Synthesis
    Y. Inokuma, T. Yoneda, Y. Ide, S. Yoshioka, Chem. Commun., 2020, 56, 9079-9093
    DOI: 10.1039/d0cc02977g
  • Modular Synthesis of Oligoacetylacetones via Site-Selective Silylation of Acetylacetone Derivatives
    P. Sarkar, Y. Inaba, H. Shirakura, T. Yoneda, Y. Inokuma, Org. Biomol. Chem., 2020, 18, 3297-3302
    DOI: 10.1039/d0ob00501k
  • Chiral Monolayers with Achiral Tetrapod Molecules on Highly Oriented Pyrolytic Graphite
    H. Asakawa, S. Matsui, Q. T. Trinh, H. Hirao, Y. Inokuma, T. Ogoshi, S. Tanaka, K. Komatsu, A. Ohta, T. Asakawa, T. Fukuma, J. Phys. Chem. C, 2020, 124, 7760-7767
    DOI: 10.1021/acs.jpcc.9b11246
  • Supramolecular Conformational Control of Aliphatic Oligoketones by Rotaxane Formation
    Y. Manabe, K. Wada, Y. Baba, T. Yoneda, T. Ogoshi, Y. Inokuma, Org. Lett., 2020, 22, 3224-3228
    DOI: 10.1021/acs.orglett.0c01010
  • Luminescent Coordination Polymers Constructed from a Flexible, Tetradentate Diisopyrazole Ligand and Copper(I) Halides
    T. Yoneda, C. Kasai, Y. Manabe, M. Tsurui, Y. Kitagawa, Y. Hasegawa, P. Sarkar, Y. Inokuma, Chem. Asian J., 2020, 15, 601-605
    DOI: 10.1002/asia.201901682

2019年

  • Control over Coordination Self-Assembly of Flexible, Multidentate Ligands by Stepwise Metal Coordination of Isopyrazole Subunits
    Y. Ashida, Y. Manabe, S. Yoshioka, T. Yoneda, Y. Inokuma, Dalton Trans., 2019, 48, 818-822
    DOI: 10.1039/c8dt04935a
  • Aliphatic Polyketones as Shapable Molecular Chains
    Y. Inokuma, J. Syn. Org. Chem. Jpn., 2019, 77, 1078-1085
    DOI: 10.5059/yukigoseikyokaishi.77.1078
  • Two-Step Transformation of Aliphatic Polyketones into π-Conjugated Polyimines
    Y. Manabe, M. Uesaka, T. Yoneda, Y. Inokuma, J. Org. Chem., 2019, 84, 9957-9964
    DOI: 10.1021/acs.joc.9b01119